12 resultados para Oksenberg, Michel

em Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco


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El trabajo analiza las políticas de cooperación al desarrollo llevadas a cabo por las principales instituciones públicas del País Vasco durante los últimos 25 años. Para este propósito, el estudio se divide en dos grandes apartados. El primero se centra en el examen del diseño de dichas políticas, mientras que el segundo está orientado al análisis de la manera en que las mismas se han llevado a la práctica. Para ello, se han estudiado más de 300 documentos de siete administraciones de la CAPV y casi 7.000 intervenciones financiadas por ellas.

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Lan honek, azken 25 urtetan zehar Euskal Herriko erakunde nagusienek aurrera eramandako Garapenerako Lankidetza politikak ditu aztergai. Helburu honekin, lana bi multzo nagusitan banatu da. Lehen analisia, aipaturiko politiken diseinuan oinarritzen da; eta bigarren analisiak aldiz, politika horiek aurrera eramandako modua du ikergai. Honetarako, Euskal Autonomia Erkidegoko zazpi erakunde nagusienetako 300 dokumentutik gora eta hauek finantzaturiko ia 7.000 jarduera aztertu dira.

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El texto que aquí se presenta es el resultado del trabajo llevado a cabo por el Grupo de Investigación sobre Análisis y Evaluación de Políticas de Cooperación al Desarrollo del Instituto Hegoa (UPV/EHU). El punto de partida del mismo es la preocupación por la todavía escasa fundamentación teórica de la cooperación descentralizada, pese a la importancia adquirida por la misma en algunos casos como el español. Desde esas premisas, se presenta un marco de referencia para el examen de dicha cooperación descentralizada, en base al cual se plantea asimismo un sistema de indicadores que pueda facilitar los procesos de análisis y evaluación de las políticas puestas en marcha en este ámbito.

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Presentado en el Simposio "La imagen del sexo en la antigüedad: ciclos de renovación de la vida", organizado por el Instituto de Historia del CSIC y celebrado en Barcelona del 21 al 23 de marzo de 2002.

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CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymocyte differentiation. In this study, we performed a haptag SNP screen of the CD6 gene locus using a total of thirteen tagging SNPs, of which three were non-synonymous SNPs, and replicated the recently reported GWAS SNP rs650258 in a Spanish-Basque collection of 814 controls and 823 cases. Validation of the six most strongly associated SNPs was performed in an independent collection of 2265 MS patients and 2600 healthy controls. We identified association of haplotypes composed of two non-synonymous SNPs [rs11230563 (R225W) and rs2074225 (A257V)] in the 2nd SRCR domain with susceptibility to MS (Pmax(T) permutation=161024). The effect of these haplotypes on CD6 surface expression and cytokine secretion was also tested. The analysis showed significantly different CD6 expression patterns in the distinct cell subsets, i.e. – CD4+ naı¨ve cells, P = 0.0001; CD8+ naı¨ve cells, P,0.0001; CD4+ and CD8+ central memory cells, P = 0.01 and 0.05, respectively; and natural killer T (NKT) cells, P = 0.02; with the protective haplotype (RA) showing higher expression of CD6. However, no significant changes were observed in natural killer (NK) cells, effector memory and terminally differentiated effector memory T cells. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4+ and CD8+ T cells.

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En une génération, entre 1975 et 1995, le paysage du marché du travail auquel les jeunes font face a radicalement changé.

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El libro está editado en bilingüe castellano-euskera

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Background: Two distinct trends are emerging with respect to how data is shared, collected, and analyzed within the bioinformatics community. First, Linked Data, exposed as SPARQL endpoints, promises to make data easier to collect and integrate by moving towards the harmonization of data syntax, descriptive vocabularies, and identifiers, as well as providing a standardized mechanism for data access. Second, Web Services, often linked together into workflows, normalize data access and create transparent, reproducible scientific methodologies that can, in principle, be re-used and customized to suit new scientific questions. Constructing queries that traverse semantically-rich Linked Data requires substantial expertise, yet traditional RESTful or SOAP Web Services cannot adequately describe the content of a SPARQL endpoint. We propose that content-driven Semantic Web Services can enable facile discovery of Linked Data, independent of their location. Results: We use a well-curated Linked Dataset - OpenLifeData - and utilize its descriptive metadata to automatically configure a series of more than 22,000 Semantic Web Services that expose all of its content via the SADI set of design principles. The OpenLifeData SADI services are discoverable via queries to the SHARE registry and easy to integrate into new or existing bioinformatics workflows and analytical pipelines. We demonstrate the utility of this system through comparison of Web Service-mediated data access with traditional SPARQL, and note that this approach not only simplifies data retrieval, but simultaneously provides protection against resource-intensive queries. Conclusions: We show, through a variety of different clients and examples of varying complexity, that data from the myriad OpenLifeData can be recovered without any need for prior-knowledge of the content or structure of the SPARQL endpoints. We also demonstrate that, via clients such as SHARE, the complexity of federated SPARQL queries is dramatically reduced.

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Resumen ejecutivo en euskera, inglés y español. Informe completo en español

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Este trabajo se ha desarrollado a partir de la edición de las inscripciones romanas del País Vasco dentro del proyecto PETRAE Hispaniarum (Université Michel de Montaigne-Bordeaux III, Francia).