Two Nuclear Localization Signals in USP1 Mediate Nuclear Import of the USP1/UAF1 Complex

9 p. : il.

Communities in complex networks

The study of complex networks has attracted the attention of the scientific community for many obvious reasons. A vast number of systems, from the brain to ecosystems, power grid, and the Internet, can be represented as large complex networks, i.e, assemblies of many interacting components with nontrivial topological properties. The link between these components can describe a global behaviour such as the Internet traffic, electricity supply service, market trend, etc. One of the most relevant topological feature of graphs representing these complex systems is community structure which aims to identify the modules and, possibly, their hierarchical organization, by only using the information encoded in the graph topology. Deciphering network community structure is not only important in order to characterize the graph topologically, but gives some information both on the formation of the network and on its functionality.

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli

11 p.

Synthetic scope and DFT analysis of the chiral binap-gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes

he 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(S-a)-Binap.AuTFA](2). The alanine-derived oxazolone only reacts with tert-butyl acrylate giving anomalous regiochemistry, which is explained and supported by Natural Resonance Theory and Nucleus Independent Chemical Shifts calculations. The origin of the high enantiodiscrimination observed with maleimides and tert-butyl acrylate is analyzed using DFT computed at M06/Lanl2dz//ONIOM(b3lyp/Lanl2dz:UFF) level. Several applications of these cycloadducts in the synthesis of new proline derivatives with a 2,5-trans-arrangement and in the preparation of complex fused polycyclic molecules are described.

Analysis of Spanish text-thesaurus as a complex network

[EN]Based on the theoretical tools of Complex Networks, this work provides a basic descriptive study of a synonyms dictionary, the Spanish Open Thesaurus represented as a graph. We study the main structural measures of the network compared with those of a random graph. Numerical results show that Open-Thesaurus is a graph whose topological properties approximate a scale-free network, but seems not to present the small-world property because of its sparse structure. We also found that the words of highest betweenness centrality are terms that suggest the vocabulary of psychoanalysis: placer (pleasure), ayudante (in the sense of assistant or worker), and regular (to regulate).

Towards complex system design and management in the engineering domain – the smart grid challenge

This is an Author's Accepted Manuscript of an article published in “Emergence: Complexity and Organization”, 15 (2), pp. 14-22 (2013), copyright Taylor & Francis.

Modeling smart grids as complex systems through the implementation of intelligent hubs

ICINCO 2010

A complex systems modelling approach for decentralized simulation of electrical microgrids

ICECCS 2010

Aspects of quality control of wind profiler measurements in complex topography

It is well known in the scientific community that some remote sensing instruments assume that sample volumes present homogeneous conditions within a defined meteorological profile. At complex topographic sites and under extreme meteorological conditions, this assumption may be fallible depending on the site, and it is more likely to fail in the lower layers of the atmosphere. This piece of work tests the homogeneity of the wind field over a boundary layer wind profiler radar located in complex terrain on the coast under different meteorological conditions. The results reveal the qualitative importance of being aware of deviations in this homogeneity assumption and evaluate its effect on the final product. Patterns of behavior in data have been identified in order to simplify the analysis of the complex signal registered. The quality information obtained from the homogeneity study under different meteorological conditions provides useful indicators for the best alternatives the system can offer to build wind profiles. Finally, the results are also to be considered in order to integrate them in a quality algorithm implemented at the product level.

Diseño e implementación de un sistema para la validación de la recomendación G.1031 y P.1501 de la ITU-T

[ES]El objetivo principal de este trabajo es el diseño y desarrollo de un sistema para la validación de las metodologías propuestas en el borrador de recomendación P.STMWeb [1] “Metodología para la evaluación subjetiva de la calidad percibida en la navegación web”. Como resultado de la validación realizada con el sistema han sido aprobadas las recomendaciones G.1031 [5] “Factores del QoE en web browsing” y P.1501 [6] “Metodología de prueba subjetiva para web browsing” de la ITU-T. El sistema propuesto se ha diseñado en base a las especificaciones marcadas en el borrador de la recomendación en vías de estandarización [P.STMWeb].Estas especificaciones han servido de base para el diseño e implementación de un sistema que permite una navegación web interactiva, con control y actualización de páginas web en base a variaciones de parámetros de red, como el retardo en un entorno controlado. Así mismo siguiendo la metodología establecida en el borrador de recomendación anteriormente mencionado se ha diseñado y desarrollado un sistema de encuestas para evaluar de forma subjetiva la calidad experimentada por los usuarios (QoE) en la navegación web. Para el diseño del sistema de encuestas, se analizaron y utilizaron como especificaciones los diferentes factores que se contemplan en el borrador de recomendación G.QoE-Web [2] “Factores relevantes y casos de uso para la QoE Web” de la ITU-T. En base al diseño realizado, se ha desarrollado un sistema que permite analizar la calidad experimentada por los usuarios en la navegación Web.

Complex systems in quantum technologies

124 p.

Estudio de la Calidad Experimentada (QoE) en el Servicio de Navegación Web: Contribución a la Validación de las Recomendaciones ITU-T P.1501 e ITU-T G.1031

Muchos de los servicios que hasta hace relativamente poco tiempo eran ofertados únicamente por los operadores de telecomunicaciones, han pasado en la actualidad a ser prestados por terceros gracias al modelo de servicios en la nube, impulsando el auge de este modelo frente al tradicional. Esto trae consigo un incremento en la complejidad en la implantación por parte del proveedor de políticas para la gestión de la QoS demandada por el cliente.En este nuevo escenario, el concepto de calidad de servicio ha venido evolucionando desde su definición clásica, entendida como el análisis objetivo de los indicadores intrínsecos de calidad que definen el rendimiento de un servicio, hacia una visión subjetiva centrada en el punto de vista del cliente respecto a dicho servicio. En este contexto, organismos de estandarización como la ITU, a través de sus grupos de trabajo, están fomentando el interesante planteamiento de abordar los servicios de telecomunicaciones ampliamente asentados y más que estudiados desde la vertiente clásica de la QoS, desde este nuevo prisma enfocado al cliente, en el que poder establecer una metodología de estudio de la QoE en dichos servicios. En particular, el trabajo presentado en este documento se asienta en la validación del draft de la recientemente aprobada recomendación ITU-T P.1501 (Metodología de test subjetiva para el servicio de navegación web), así como en la contribución a la recomendación G.1031 (Factores de QoE en el servicio de navegación web).

Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex

Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, helices A and B, and it is required for exit from the endoplasmic reticulum. However, the molecular mechanisms by which CaM controls channel trafficking are currently unknown. Here we used two complementary approaches to explore the molecular events underlying the association between CaM and Kv7.2 and their regulation by Ca2+. First, we performed a fluorometric assay using dansylated calmodulin (D-CaM) to characterize the interaction of its individual lobes to the Kv7.2 CaM binding site (Q2AB). Second, we explored the association of Q2AB with CaM by NMR spectroscopy, using N-15-labeled CaM as a reporter. The combined data highlight the interdependency of the N- and C-lobes of CaM in the interaction with Q2AB, suggesting that when CaM binds Ca2+ the binding interface pivots between the N-lobe whose interactions are dominated by helix B and the C-lobe where the predominant interaction is with helix A. In addition, Ca2+ makes CaM binding to Q2AB more difficult and, reciprocally, the channel weakens the association of CaM with Ca2+.

Aspects of quality control of wind profiler measurements in complex topography

It is well known in the scientific community that some remote sensing instruments assume that sample volumes present homogeneous conditions within a defined meteorological profile. At complex topographic sites and under extreme meteorological conditions, this assumption may be fallible depending on the site, and it is more likely to fail in the lower layers of the atmosphere. This piece of work tests the homogeneity of the wind field over a boundary layer wind profiler radar located in complex terrain on the coast under different meteorological conditions. The results reveal the qualitative importance of being aware of deviations in this homogeneity assumption and evaluate its effect on the final product. Patterns of behavior in data have been identified in order to simplify the analysis of the complex signal registered. The quality information obtained from the homogeneity study under different meteorological conditions provides useful indicators for the best alternatives the system can offer to build wind profiles. Finally, the results are also to be considered in order to integrate them in a quality algorithm implemented at the product level.

Hydrothermal Synthesis and Study of Inorganic-Organic Hybrid Vanadate of Nickel(II) Coordination Complex with Pyrazine, Ni3(C4H4N2)3(V8O23)

Artículo científico: postprint