Adición conjugada asimétrica de equivalentes umpolung de acilo y carboxilo : auxiliares quirales vs organocatálisis

365 p.

Localización gráfica de los expedientes patrimoniales de Vitoria en el AHPA

Direcciones de correo electrónico de las autoras: amaya999@hotmail.com ; nagores@hotmail.es

Inventario Digital de Cartografía Histórica de Álava

A través de este inventario se pretende facilitar la información y el acceso de los investigadores a la documentación cartográfica antigua de cualquier parte del territorio histórico alavés.

Activación de aldehídos a,b-insaturados mediante aminocatálisis en procesos enantioselectivos. Cicloadiciones (3+2) y reacciones en cascada Michael/Henry

During the research that it is summarized in the present memory, the activation of enals via iminium ion catalysis in different transformations has been studied. Firstly, a 1,3-dipolar cycloaddition between stable azomethine ylides and a,b-unsaturated aldehydes catalyzed by a chiral imidazolidinone derivative has been optimized. Employing this methodology we have synthesized a large range of densely substituted pyrroloisoquinolines and pyrrolophthalazines with good yields and high values of diastereo- and enantioselectivity. Moreover, a mechanistic study has been carried out based on DFT calculations and experimental data which have allowed us to propose that the (3+2) cycloaddition reaction follows a sequential Michael addition/Mannich cyclization pathway. The formation of the iminium ion as a result of the condensation between the a,b-unsaturated aldehyde and the catalyst plays an essential role, regarding both reactivity and stereoselectivity. On the other hand we have developed a methodology to carry out a cascade Michael/Henry reaction followed by a sequential dehydration. Starting from simple substrates (2-nitromethylacrilates and a,b-unsaturated aldehydes) and employing a prolinol-derivative catalyst a series of quiral nitrocyclohexadienes have been synthesized.

Procedimiento de refutación para un conjunto de restricciones sobre documentos XML

We present a prototype that implements a set of logical rules to prove the satis ability for a class of speci cations on XML documents. Speci cations are given by means of constraints built on Boolean XPath patterns. The main goal of this tool is to test if a given speci cation is satis able or not, showing the history of the execution. It can also be used to test if a given document is a model of a given speci cation and, as a subproduct, it allows to look for all the relations (monomorphisms) between two patterns or the result of doing some operations by combining patterns in di erent ways. The results of these operations are visually shown and therefore the tool makes these operations more understandable. The implementation of the algorithm has been written in Prolog but the prototype has a Java interface for an easy and friendly use.

Bakerako hezkuntza: bizikidetza sustatzeko tresna

Nivel educativo: Grado. Duración (en horas): De 21 a 30 horas

Aplicaciones de nanoparticulas de magnetita de origen bacteriano

Uso de nanopartículas magnéticas extraídas de bacterias magnetotácticas para su estudio y aplicación en la hipertermia magnética. Idioma Castellano

Síntesis de catalizadores quirales basados en alcaloides de Cincona

La síntesis de compu estos enantiopuros es de vital importancia en el ámbito de la industria farmacéuti ca y agroquímica. 1 Es mucha la bibliografía que recoge información sobre la importancia de la obtención de compuestos quirales como un único enantiómero especialmente cuando el compuesto es bioactivo . La importancia reside en que los sistemas biológicos (p roteínas, enzimas, aminoácidos, etc.) son entidades quirales capaces de reconocer y diferenciar los miembros de una pareja de enantiómeros, y , en ocasiones , cada uno provoca una respuesta diferente en el cuerpo humano. El principal problema se presenta c uando u no de los enantiómero s tiene una actividad diferente de la esperad

Complexity and Uniqueness of the Aromatic Profile of Smoked and Unsmoked Herreno Cheese

In this work, the volatile fraction of unsmoked and smoked Herreno cheese, a type of soft cheese from the Canary Islands, has been characterized for the first time. In order to evaluate if the position in the smokehouse could influence the volatile profile of the smoked variety, cheeses smoked at two different heights were studied. The volatile components were extracted by Solid Phase Microextraction using a divinylbenzene/carboxen/polydimethylsiloxane fiber, followed by Gas Chromatography/Mass Spectrometry. In total, 228 components were detected. The most numerous groups of components in the unsmoked Herreno cheese were hydrocarbons, followed by terpenes and sesquiterpenes, whereas acids and ketones were the most abundant. It is worth noticing the high number of aldehydes and ketones, and the low number of alcohols and esters in this cheese in relation to others, as well as the presence of some specific unsaturated hydrocarbons, terpenes, sesquiterpenes and nitrogenated derivatives. The smoking process enriches the volatile profile of Herreno cheese with ketones and diketones, methyl esters, aliphatic and aromatic aldehydes, hydrocarbons, terpenes, nitrogenated compounds, and especially with ethers and phenolic derivatives. Among these, methylindanones or certain terpenes like a-terpinolene, have not been detected previously in other types of smoked cheese. Lastly, the results obtained suggest a slightly higher smoking degree in the cheeses smoked at a greater height.

Closed G2 forms and special metrics

170 p.

Inventario Digital de "La Cartografía Histórica de Euskadi"

En esta obra aparecen descritos 3.391 mapas y planos, localizados en 76 archivos y bibliotecas anteriores a 1.900. Entre ellos se incluyen también algunos que si bien no han podido ser consultados, el equipo investigador consideró de interés dar a conoce su existencia.