El fraude empresarial: perspectiva internacional

Este trabajo analiza el fraude empresarial desde una perspectiva internacional. En los últimos años, ha estado muy presente en casos como el de Enron, WorldCom, Royal Ahold o PARMALAT, en los que se ven afectados la propia empresa, los trabajadores, el gobierno y, especialmente, los inversores, con pérdidas que pueden alcanzar millones de dólares. El fraude también afecta a la imagen de las empresas y en la motivación de los trabajadores, y además a menudo es causa de denuncias y penas de prisión. En función del tamaño de la empresa y del sector, la frecuencia con la que se cometen los actos fraudulentos y las pérdidas causadas varían. Asimismo, estos fraudes afectan a todas las regiones del mundo, aunque de manera desigual. Pero es en aquellas regiones más desarrolladas donde se le presta más atención al tema, y donde se han tomado numerosas medidas para intentar impedir estos actos ilícitos. Algunas de las más importantes son las propuestas por las Naciones Unidas: El Pacto Mundial y la Convención contra la Corrupción. También cabe destacar la Oficina Europea de Lucha Contra el Fraude, a nivel europeo, o la Foreign Corrupt Practices Act y la Ley Sarbanes-Oxley, en Estados Unidos. A pesar de estas medidas, en los últimos años el nivel de fraude ha aumentado.

Ca2+ Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route

Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and catalyzes the unregulated formation of cAMP, hampering important bactericidal functions of these immune cells that eventually cause cell death by apoptosis and/or necrosis. Additionally, ACT permeabilizes cells through pore formation in the target cell membrane. Recently, we demonstrated that ACT is internalised into macrophages together with other membrane components, such as the integrin CD11b/CD18 (CR3), its receptor in these immune cells, and GM1. The goal of this study was to determine whether ACT uptake is restricted to receptor-bearing macrophages or on the contrary may also take place into cells devoid of receptor and gain more insights on the signalling involved. Here, we show that ACT is rapidly eliminated from the cell membrane of either CR3-positive as negative cells, though through different entry routes, which depends in part, on the target cell physiology and characteristics. ACT-induced Ca2+ influx and activation of non-receptor Tyr kinases into the target cell appear to be common master denominators in the different endocytic strategies activated by this toxin. Very importantly, we show that, upon incubation with ACT, target cells are capable of repairing the cell membrane, which suggests the mounting of an anti-toxin cell repair-response, very likely involving the toxin elimination from the cell surface.

On the economics of the "meeting competition defense" under the Robinson-Patman Act

Documento de trabajo

Global and local challenges for best practices in assessment. The 9th Conference on the International Test Commission. Book of abstracts

The 9th International Test Commission Conference (ITC) took place at the Miramar Palace in San Sebastian, Spain, between the 2nd and 5th of July, 2014. The Conference was titled, “Global and Local Challenges for Best Practices in Assessment.” The International Test Commission, ITC (www.intestcom.org), is an association of national psychological associations, test commissions, publishers, and other organizations, as well as individuals who are committed to the promotion of effective testing and assessment policies and to the proper development, evaluation, and uses of educational and psychological instruments. The ITC facilitates the exchange of information among members and stimulates their cooperation on problems related to the construction, distribution, and uses of psychological and educational tests and other psychodiagnostic tools. This volume contains the abstracts of the contributions presented at the 9th International Test Commission Conference. The four themes of the Conference were closely linked to the goals of the ITC: - Challenges and Opportunities in International Assessment. - Application of New Technoloogies and New Psychometric Models in Testing. - Standards and Guidelines for Best Testing Practices. - Testing in Multilingual and Multicultural Contexts.