Una historia forestal inédita. Las ordenanzas de Zumarraga de 1547: un ejemplo de desarrollo sostenible en el siglo XVI guipuzcoano

Este volúmen recoge las "IX Jornadas de Historia Local: de los fueros locales a las ordenanzas municipales en Euskal Herria" (Vitoria-Gasteiz, 2006)

Biosimilar medicines in dermatology: key aspects.

Article reproduced (or made available) with permission of Practical Dermatology®, www.practicaldermatology.com.

Análisis de precios del mercado diario de electricidad español

El trabajo analiza los precios de la electricidad del mercado diario español. En el mismo se realiza un estudio del mercado eléctrico español y sus componentes junto con un análisis de los cambios regulatorios más significativos durante el periodo muestral. A partir de allí, se analiza la muestra a través de los estadísticos descriptivos principales. Luego se presenta un modelo general que es analizado a partir de los resultados empíricos principales obtenidos con su estimación. Finalmente, se realizan ajustes al mismo para obtener un modelo simplificado que se ajuste mejor a lo que se quiere conseguir, que es analizar la evolución de los precios de la electricidad. Los resultados del ajuste arrojan que los precios horarios dependen en su mayor parte de los precios de las horas anteriores. También que el modelo recoge muy bien la estacionalidad mensual y horaria que presenta la muestra. Por otro lado, características de la serie de precios como son la volatilidad y los saltos no quedan bien recogidos por el modelo, lo que lleva a plantearse la búsqueda de modelos alternativos.

Identification of the main allergen sensitizers in an Iran asthmatic population by molecular diagnosis

Background: There has been a significant growth in the prevalence of allergy, mainly associated to IgE-mediated disorders such as asthma and rhinitis. The identification of atopy in asthmatic patients through the measurement of specific IgE can help to identify risk factors that cause asthmatic symptoms in patients. The development and use of individualized allergen-based tests by the Component Resolved Diagnosis has been a crucial advance in the accurate diagnosis and control of allergic patients. The objective of this work was to assess the usefulness of molecular diagnosis to identify environmental allergens as possible factors influencing the development and manifestation of asthma in a group of asthmatic patients from Iran. Methods: Studied population: 202 adult asthmatic patients treated at the Loghman Hakim Hospital and Pasteur Institute of Teheran (Iran) from 2011 to 2012. Specific IgE determined by the ImmunoCAP system were used to both evaluate the patients' atopic condition and the molecules involved in the allergic sensitization. SDS-PAGE IgE-immunoblotting associated with mass spectrometry was carried out to study the cockroach IgE-binding sensitizing proteins. Results: Forty-five percent of all patients could be considered atopic individuals. Eighty-two percent of atopic patients were sensitized to pollen allergens. The Salsola kali (Sal k 1) and the Phleum pratense (rPhl p 1 and/or rPhl p 5) major allergens were the most common sensitizers among pollens (71% and 18%, respectively). Thirty-five percent of the atopic population was sensitized to cockroach. Four different allergens, including a previously unknown alpha-amylase, were identified in the cockroach extract. No significant associations could be demonstrated between the severity of asthma and the specific IgE levels in the atopic population. Statistical analysis identified the Sal k 1 as the main protein allergen influencing the development and expression of asthma in the studied population. Conclusions: Pollen and cockroach were the most relevant allergen sources in the asthmatic population. The Salsola kali major allergen was the main cause for sensitization in the atopic patients suffering asthma. Using the Component Resolved Diagnosis, it was possible to identify a new Blattella germanica cockroach allergen (Blattella alpha amylase 53 kDa) that could sensitize a relevant percentage of this population.