Evaluation of the conventional surveying equipment applied to deformation analysis of heritage buildings. A case study: the bell tower of Santa María la Blanca church in Agoncillo (La Rioja, Spain)

Contributed to: "Measuring the Changes": 13th FIG International Symposium on Deformation Measurements and Analysis; 4th IAG Symposium on Geodesy for Geotechnical and Structural Enginering (Lisbon, Portugal, May 12-15, 2008).

Efecto de la temperatura en el subproteoma de membrana externa de Escherichia coli

[es]En sus habitas naturales, los microorganismos están en un estado constante de adaptación a cambios tanto bióticos como abióticos. Ante situaciones de estré s, como por ejemplo cambios en nutriente s, temperatura o de osmolar idad , la s estrategias de supervivencia o adapta ción se puede n manifestar como cambios fenotípicos y genotípicos . En este estudio se analizaron algunos mecanismos de cambio asociados a la supervivencia y la composición proteica de membrana en Escherichia coli (bact eria mesófila), al ser expuesta a condiciones de ayuno y a temperaturas subó ptimas (4 y 20ºC). Al realizar un análisis comparativ o del subproteoma de membrana entre estas dos temperaturas, se observó que ante la ausencia de nutrientes, E. coli respondía de forma diferen te en la expresió n de proteí nas as ociadas a estructura (lipoproteínas), conservación de la energía y transporte, con un aumento en el nú mero de proteí nas expresadas a 20 o C. Se observó, además, una importante diferencia en la supervivencia a estas dos temperaturas, donde el número de células en el estado viable no cultivable (VNC) representaron un porcentaje importante a 20ºC

The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals

Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial adenomatous polyposis the most common forms. Lynch syndrome tumors develop mainly as a consequence of defective DNA mismatch repair associated with germline mutations in MLH1, MSH2, MSH6 and PMS2. A significant proportion of variants identified by screening these genes correspond to missense or noncoding changes without a clear pathogenic consequence, and they are designated as "variants of uncertain significance'', being the c.1852_1853delinsGC (p.K618A) variant in the MLH1 gene a clear example. The implication of this variant as a low-penetrance risk variant for CRC was assessed in the present study by performing a case-control study within a large cohort from the COGENT consortium-COST Action BM1206 including 18,723 individuals (8,055 colorectal cancer cases and 10,668 controls) and a case-only genotype-phenotype correlation with several clinical and pathological characteristics restricted to the Epicolon cohort. Our results showed no involvement of this variant as a low-penetrance variant for colorectal cancer genetic susceptibility and no association with any clinical and pathological characteristics including family history for this neoplasm or Lynch syndrome.

Gure buruaren onarpenetik, gizakion errespetura

[eus] Gaur egungo eskoletan, oraindik ere, zoritxarrez, behar besteko garrantzirik ematen ez zaion eta sendotu behar den ikasleen autoezagutza fisikoaren inguruan, honako landa-lana diseinatu eta ikasleekin burutu egin da, hauengan aldaketa bat sortarazteko asmoarekin. Horretarako, prestatutako ariketa desberdinen bitartez, ikasleen arrazonamendu maila, baita maila emozionala ere landu egin da. Kontuan izanda, autoezagutzan, aldaketak epe luzean ematen direla, esku-hartze honen bidez ez dira aldaketa handirik edo esanguratsurik nabarmendu. Dena den, errespetuaren balorea ikasleengan transmititzea lortu egin da. Hori dela eta, landa lana burutu eta gero, egindakoaren inguruan, autokritika egin da.

Synthesis, characterization, and preliminary application of new biocompatible nanogels useful as anticancer drug delivery systems

253 p.

Detection of Atomic Scale Changes in the Free Volume Void Size of Three-Dimensional Colorectal Cancer Cell Culture Using Positron Annihilation Lifetime Spectroscopy

5 p.