ICGE: an R package for detecting relevant clusters and atypical units in gene expression

Background: Gene expression technologies have opened up new ways to diagnose and treat cancer and other diseases. Clustering algorithms are a useful approach with which to analyze genome expression data. They attempt to partition the genes into groups exhibiting similar patterns of variation in expression level. An important problem associated with gene classification is to discern whether the clustering process can find a relevant partition as well as the identification of new genes classes. There are two key aspects to classification: the estimation of the number of clusters, and the decision as to whether a new unit (gene, tumor sample ... ) belongs to one of these previously identified clusters or to a new group. Results: ICGE is a user-friendly R package which provides many functions related to this problem: identify the number of clusters using mixed variables, usually found by applied biomedical researchers; detect whether the data have a cluster structure; identify whether a new unit belongs to one of the pre-identified clusters or to a novel group, and classify new units into the corresponding cluster. The functions in the ICGE package are accompanied by help files and easy examples to facilitate its use. Conclusions: We demonstrate the utility of ICGE by analyzing simulated and real data sets. The results show that ICGE could be very useful to a broad research community.

Incidental Memory of Younger and Older Adults for Objects Encountered in a Real World Context

Effects of context on the perception of, and incidental memory for, real-world objects have predominantly been investigated in younger individuals, under conditions involving a single static viewpoint. We examined the effects of prior object context and object familiarity on both older and younger adults' incidental memory for real objects encountered while they traversed a conference room. Recognition memory for context-typical and context-atypical objects was compared with a third group of unfamiliar objects that were not readily named and that had no strongly associated context. Both older and younger adults demonstrated a typicality effect, showing significantly lower 2-alternative-forced-choice recognition of context-typical than context-atypical objects; for these objects, the recognition of older adults either significantly exceeded, or numerically surpassed, that of younger adults. Testing-awareness elevated recognition but did not interact with age or with object type. Older adults showed significantly higher recognition for context-atypical objects than for unfamiliar objects that had no prior strongly associated context. The observation of a typicality effect in both age groups is consistent with preserved semantic schemata processing in aging. The incidental recognition advantage of older over younger adults for the context-typical and context-atypical objects may reflect aging-related differences in goal-related processing, with older adults under comparatively more novel circumstances being more likely to direct their attention to the external environment, or age-related differences in top-down effortful distraction regulation, with older individuals' attention more readily captured by salient objects in the environment. Older adults' reduced recognition of unfamiliar objects compared to context-atypical objects may reflect possible age differences in contextually driven expectancy violations. The latter finding underscores the theoretical and methodological value of including a third type of objects-that are comparatively neutral with respect to their contextual associations-to help differentiate between contextual integration effects (for schema-consistent objects) and expectancy violations (for schema-inconsistent objects).

Horacio: poeta versus filósofo

[EN] The author points out Horace's apparent contradition in Ode 1,10 with his own philosophical ideas. It seems to be more relevant in this poem the poetical feeling than the philosophical one.

Precariedad laboral en Europa

[ES] Tras una primera visión del concepto de precariedad y acotación del término en el ámbito europeo, este trabajo trata, por un lado, de exponer los factores y el marco social en el que se crea dicha precariedad laboral y, por otro lado, de analizar mediante diversos indicadores de calidad del empleo la incidencia en el caso de la Unión Europea y España. Se exponen la flexibilidad laboral y otros cambios empresariales, reformas legales o transformaciones en el contexto del mercado del trabajo como causantes del aumento de empleos atípicos, los cuales tiendes a ser de peor calidad. En cuanto a los indicadores de calidad utilizados destacan las tasas de actividad, la temporalidad, la estructura de la renta y el salario mínimo, el porcentaje del trabajo a tiempo parcial con respecto al total o las malas condiciones de trabajo, entre otros. Además se hace referencia a la crisis comenzada en 2007 y al efecto agravatorio de esta en la situación, especialmente en el caso de los jóvenes. Por último, se mencionan ciertas propuestas y políticas laborales.