153 resultados para FERNÁNDEZ DE TINOCO, MARÍA


Relevância:

20.00% 20.00%

Publicador:

Resumo:

One of the most controversial inquiries in academic writing is whether it is admissible to use first person pronouns in a scientific paper or not. Many professors discourage their students from using them, rather favoring a more passive tone, and thus causing novices to avoid inserting themselves into their texts in an expert-like manner. Abundant research, however, has recently attested that negotiation of identity is plausible in academic prose, and there is no need for a paper to be void of an authorial identity. Because in the course of the English Studies Degree we have received opposing prompts in the use of I, the aim of this dissertation is to throw some light upon this vexed issue. To this end, I compiled a corpus of 16 Research Articles (RAs) that comprises two sub-corpora, one featuring Linguistics RAs and the other one Literature RAs, and each, in turn, consists of articles written by American and British authors. I then searched for real occurrences of I, me, my, mine, we, us, our and ours, and studied their frequency, rhetorical functions and distribution along each paper. The results obtained certainly show that academic writing is no longer the faceless prose that it used to be, for I is highly used in both disciplines and varieties of English. Concerning functions, the most typically used roles were the use of I to take credit for the writer’s research process, and also those involving plural forms. With respect to the spatial disposition, all sections welcomed first person pronouns, but the Method and the Results/Discussion sections seem to stimulate their appearance. On the basis of these findings, I suggest that an L2 writing pedagogy that is mindful not only of the language proficiency, but also of the students’ own identity may have a beneficial effect on the composition of their texts.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Presentación de power point. Comunicación oral presentada en el 1er Simposium sobre Propiedades y Aplicaciones de MOFs y COFs, celebrado en Granada en abril de 2015

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect roughly the energetic status of the cell, and a precise ratio relating them was proposed by Atkinson as the adenylate energy charge (AEC). Under growth-phase conditions, cells maintain the AEC within narrow physiological values, despite extremely large fluctuations in the adenine nucleotides concentration. Intensive experimental studies have shown that these AEC values are preserved in a wide variety of organisms, both eukaryotes and prokaryotes. Here, to understand some of the functional elements involved in the cellular energy status, we present a computational model conformed by some key essential parts of the adenylate energy system. Specifically, we have considered (I) the main synthesis process of ATP from ADP, (II) the main catalyzed phosphotransfer reaction for interconversion of ATP, ADP and AMP, (III) the enzymatic hydrolysis of ATP yielding ADP, and (IV) the enzymatic hydrolysis of ATP providing AMP. This leads to a dynamic metabolic model (with the form of a delayed differential system) in which the enzymatic rate equations and all the physiological kinetic parameters have been explicitly considered and experimentally tested in vitro. Our central hypothesis is that cells are characterized by changing energy dynamics (homeorhesis). The results show that the AEC presents stable transitions between steady states and periodic oscillations and, in agreement with experimental data these oscillations range within the narrow AEC window. Furthermore, the model shows sustained oscillations in the Gibbs free energy and in the total nucleotide pool. The present study provides a step forward towards the understanding of the fundamental principles and quantitative laws governing the adenylate energy system, which is a fundamental element for unveiling the dynamics of cellular life.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

218p. -- Tesis con mención "Doctor europeus" realizada en el periodo de Octubre 2005-Mayo 2010, en el Grupo "Materiales+Tecnologías" (GMT).

Relevância:

20.00% 20.00%

Publicador:

Resumo:

[Es]La labor cuidadora es conocida desde la antigüedad y así lo demuestran los estudios realizados. En el transcurso de la historia ha existido una evolución en el concepto de la salud-enfermedad. Y a su vez la enfermería ha sufrido trasformaciones importantes, situándose hoy en día en la posición en la que se la conoce. Diferentes acontecimientos favorecieron ésta evolución, como los conflictos bélicos. Por ello se realiza un estudio durante la Guerra Civil Española (1936-1939), para conocer la situación de la enfermería en la época, los cuidados que ofrecieron las/los enfermeras/os, la importancia de la colaboración social para la realización de estos cuidados y el consecuente beneficio de todo ello. Dedicando una sección al País vasco. Se realiza una revisión bibliográfica recurriendo principalmente a fuentes primarias para la obtención de documentación. Dando como resultado, un estudio histórico de carácter analítico-sintético. Se obtiene como resultado una visión global de la labor cuidadora de enfermeras/os, del voluntariado y de la ayuda internacional en el transcurso del conflicto. Destaca la importancia de la formación, la disciplina, los reglamentos y guías. Resulta imprescindible señalar el importante papel que desarrolló la Cruz Roja durante todo el conflicto. El conocimiento sobre el importante papel de la enfermería y los cuidados aplicados durante la guerra, contribuye a una reflexión personal de la importancia que éstas tuvieron, y demuestra la necesidad de una indagación más profunda y amplia.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic at diagnosis, new non-invasive approaches are needed to determine the hepatic lipid content in terms of diagnosis, treatment and control of disease progression. Here, we investigated the potential of magnetic resonance imaging (MRI) to quantitate and monitor the hepatic triglyceride concentration in humans. Methods: A prospective study of diagnostic accuracy was conducted among 129 consecutive adult patients (97 obesity and 32 non-obese) to compare multi-echo MRI fat fraction, grade of steatosis estimated by histopathology, and biochemical measurement of hepatic triglyceride concentration (that is, Folch value). Results: MRI fat fraction positively correlates with the grade of steatosis estimated on a 0 to 3 scale by histopathology. However, this correlation value was stronger when MRI fat fraction was linked to the Folch value, resulting in a novel equation to predict the hepatic triglyceride concentration (mg of triglycerides/g of liver tissue = 5.082 + (432.104 * multi-echo MRI fat fraction)). Validation of this formula in 31 additional patients (24 obese and 7 controls) resulted in robust correlation between the measured and estimated Folch values. Multivariate analysis showed that none of the variables investigated improves the Folch prediction capacity of the equation. Obese patients show increased steatosis compared to controls using MRI fat fraction and Folch value. Bariatric surgery improved MRI fat fraction values and the Folch value estimated in obese patients one year after surgery. Conclusions: Multi-echo MRI is an accurate approach to determine the hepatic lipid concentration by using our novel equation, representing an economic non-invasive method to diagnose and monitor steatosis in humans.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

[ES]En la problemática medioambiental generada por la contaminación atmosférica hay tres aspectos que marcan las directrices de actuación institucional: la presión social, la legislación vigente y la tecnología disponible. En cuanto a este último aspecto, la biofiltración es una tecnología eficaz, asequible y sostenible basada en la actividad biodegradadora de microorganismos específicos adheridos a la superficie de un material soporte que constituye el lecho del biofiltro. La elección de un material soporte adecuado es de especial importancia para asegurar el correcto funcionamiento de los biofiltros. Esta decisión está basada en las propiedades intrínsecas del material que deben ser analizadas previamente a su uso. En este proyecto se ha seleccionado cuales son estas propiedades básicas a partir de una revisión bibliográfica, destacando la capacidad de retención de humedad, superficie específica, porosidad, y estabilidad física y química del material. En este trabajo, también se han fijado los parámetros de control que deben ser medidos de forma rutinaria en un biofiltro para asegurar la eficacia del tratamiento de descontaminación. En base a la información bibliográfica recopilada, se ha concluido que los parámetros básicos son pH, temperatura, contenido de humedad del lecho y pérdidas de carga. A nivel experimental, se han medido las pérdidas de carga generadas en biofiltros empacados con tres materiales soportes que son de especial interés para una investigación posterior a desarrollar por el grupo Biofiltración de la Universidad del País Vasco (UPV/EHU). Durante el período de arranque inicial de los tres biofiltros, las pérdidas de carga medidas fueron muy bajas en los tres casos, aunque algo superiores cuando la alimentación era en sentido ascendente frente al flujo descendente. Sin embargo, cuando se midieron las pérdidas de carga bajo condiciones de encharcamiento del lecho, que es una de las situaciones más problemáticas en un biofiltro, todos los soportes presentaron un aumento puntual de la pérdida de carga aunque la tendencia en los días posteriores fue claramente descendente, recuperando valores de operación habituales. La comparativa del comportamiento frente a las pérdidas de carga permitió seleccionar el soporte más idóneo de los tres analizados, aunque los otros dos podrían ser alternativas viables en caso de sustitución.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Este trabajo ha sido realizado dentro del Grupo de Investigación GIU 10-19 “LITTERARVM. Grupo de Investigación en Literatura, Retórica y Tradición Clásica” de la UPV/EHU.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Background: Advances in the knowledge of renal neoplasms have demonstrated the implication of several proteases in their genesis, growth and dissemination. Glutamyl-aminopeptidase (GAP) (EC. 3.4.11.7) is a zinc metallopeptidase with angiotensinase activity highly expressed in kidney tissues and its expression and activity have been associated wtih tumour development. Methods: In this prospective study, GAP spectrofluorometric activity and immunohistochemical expression were analysed in clear-cell (CCRCC), papillary (PRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytoma (RO). Data obtained in tumour tissue were compared with those from the surrounding uninvolved kidney tissue. In CCRCC, classic pathological parameters such as grade, stage and tumour size were stratified following GAP data and analyzed for 5-year survival. Results: GAP activity in both the membrane-bound and soluble fractions was sharply decreased and its immunohistochemical expression showed mild staining in the four histological types of renal tumours. Soluble and membrane-bound GAP activities correlated with tumour grade and size in CCRCCs. Conclusions: This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

170 p.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Consiste en la realización de una auditoría de cuentas aplicable a una sociedad anónima deportiva ficticia, con el objetivo de llevar a cabo la emisión del informe de auditoría correspondiente que refleje la opinión del auditor.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value= 4x10(-4)). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Hoy en día, las empresas deben adaptarse a los cambios continuos del mercado, donde el comercio electrónico crece cada año y las redes sociales y los dispositivos móviles conectan a los consumidores con las marcas. El marketing ha evolucionado gracias a las nuevas tecnologías de información y comunicación para responder a un consumidor social que está conectado gran parte del día, es exigente y además, está comprometido con el medio ambiente. En un entorno muy maduro y competitivo, el cliente se ha convertido en el activo más valorado para las empresas especialmente de distribución minorista y por eso, su fidelización es un objetivo prioritario para las compañías, quienes tratan de enfocar las estrategias de marketing hacia las relaciones con los consumidores. Pero, a pesar de la infinidad de oportunidades que ofrecen las nuevas tecnologías, los programas de fidelización implantados en el entorno digital tienen un recorrido de necesaria evolución y un ajuste de mejoras para la adaptación de un medio poco estructurado a las nuevas circunstancias. A través de este trabajo fin de grado se propone dar a conocer la actualidad sobre la distribución comercial en el ámbito digital así como las tendencias en los programas de fidelización. Además, la creciente implicación en el cuidado del medio ambiente por parte de las empresas y los consumidores se incluye como una aportación original y distintiva al trabajo.