79 resultados para Manrique Saavedra, Antonio María (1837-1907)


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Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-beta 3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM.

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In the present work, the nematic glassy state of the non-symmetric LC dimer -(4-cyanobiphenyl-4-yloxy)--(1-pyrenimine-benzylidene-4-oxy) undecane is studied by means of calorimetric and dielectric measurements. The most striking result of the work is the presence of two different glass transition temperatures: one due to the freezing of the flip-flop motions of the bulkier unit of the dimer and the other, at a lower temperature, related to the freezing of the flip-flop and precessional motions of the cyanobiphenyl unit. This result shows the fact that glass transition is the consequence of the freezing of one or more coupled dynamic disorders and not of the disordered phase itself. In order to avoid crystallization when the bulk sample is cooled down, the LC dimer has been confined via the dispersion of -alumina nanoparticles, in several concentrations.

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[ES] El estudio de la flora alóctona en hábitats urbanos está adquiriendo cada vez un mayor interés por parte de la comunidad científica. Este estudio se llevó a cabo en el municipio de Basauri, situado en la provincia de Bizkaia, donde por un lado, se realizó un catálogo de la flora vascular alóctona y por otro, se realizaron muestreos de vegetación en siete hábitats diferentes, con el objetivo de evaluar el nivel de invasión en cada uno de ellos. Se identificaron un total de 50 especies alóctonas (exóticas) en el municipio, la mayor parte de ellas de origen americano, introducidas como ornamentales y que muestran comportamiento invasor. A partir de los datos de los inventarios de vegetación, se estimó que aproximadamente un 18,2% de las especies eran exóticas, entre las que destacan las que pertenecen a las familias Asteraceae, Fabaceae y Poaceae. Además, se observó que los hábitats más invadidos fueron aquellos sometidos a mayores perturbaciones, como los hábitats ruderales y los riparios, también se observó una disminución de la diversidad total de especies con el aumento de la cobertura de especies alóctonas.