Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR)

8 p.

Visual SLAM using straight lines

The present thesis is focuses on the problem of Simultaneous Localisation and Mapping (SLAM) using only visual data (VSLAM). This means to concurrently estimate the position of a moving camera and to create a consistent map of the environment. Since implementing a whole VSLAM system is out of the scope of a degree thesis, the main aim is to improve an existing visual SLAM system by complementing the commonly used point features with straight line primitives. This enables more accurate localization in environments with few feature points, like corridors. As a foundation for the project, ScaViSLAM by Strasdat et al. is used, which is a state-of-the-art real-time visual SLAM framework. Since it currently only supports Stereo and RGB-D systems, implementing a Monocular approach will be researched as well as an integration of it as a ROS package in order to deploy it on a mobile robot. For the experimental results, the Care-O-bot service robot developed by Fraunhofer IPA will be used.

Automatización de los recorridos del robot en un sistema de exploración basado en comportamientos

Automatización de los recorridos del robot en un sistema de exploración basado en comportamientos. Se muestran los resultados obtenidos en las simulaciones con Player/Stage de un sistema de exploración basado en comportamientos, donde la localización se realiza mediante los estadísticos de INCA.

Desarrollo de rutinas de control y mejora delsoftware de programación de líneas CNC

El proyecto consiste en integrar el control de una marcadora neumática de COUTH en el control de una GT100 de forma que se pueda controlar la máquina completa desde una única interfaz hombre-máquina. Además de esto se ha mejorado la interfaz existente dándole un aspecto renovado y facilitando la navegabilidad. Por último, se optimizaron unas maniobras eléctricas importantes, mejorando así el conjunto de la máquina. Español

Software de control desarrollado en ROS para teleoperar de manera eficiente el robot Kuka Lightweight mediante el háptico Phantom Omni

La teleoperación o telerobótica es un campo de la robótica que se basa en el control remoto de robots esclavo por parte de un usuario encargado de gobernar, mediante un dispositivo maestro, la fuerza y movimiento del robot. Sobre dicho usuario recaen también las tareas de percepción del entorno, planificación y manipulación compleja. Concretamente se pretende desarrollar el control software necesario para teleoperar un manipulador esclavo, Kuka Lightweigh mediante un dispositivo háptico Phamton Omni, que se comporta como maestro, sin que afecten las diferencias dinámicas y estructurales existentes entre ambos dispositivos, aportando información adicional al operador para facilitar la operación. La principal motivación de la evolución de esta tecnología se debe a la necesidad de realizar trabajos en entornos hostiles, de difícil acceso, o perjudiciales para la salud del usuario.

Propaganda de ciudades griegas

En este trabajo se describen los distintos procedimientos para hacer propaganda de las ciudades griegas en la Antigüedad.

Talla 38

Duración (en horas): De 11 a 20 horas. Destinatario: Estudiante y Docente

Genetics of Type III Bartter Syndrome in Spain, Proposed Diagnostic Algorithm

9 p.

La Educación Pikler-Lóczy : cuando educar empieza por cuidar

El sistema educativo que Emmi Pikler y su equipo establecen en el Instituto Lóczy en Budapest demuestra durante más de 60 años que el desarrollo sano y armónico de bebés y niños pequeños privados de familia y criados en institución es posible. Crea un entorno óptimo, humano y físico, para promover el desarrollo integral de la primera infancia en situación de crianza colectiva, en base a dos ejes: el establecimiento de una relación vincular privilegiada con un adulto estable que dispensa a cada niño y en cada ocasión los cuidados de la mejor manera posible, hasta sus más pequeños detalles, por lo que resultan ser cuidados de gran calidad, y la promoción de la total autonomía en el movimiento y la actividad infantil, sin ninguna intervención adulta directa, pero sí indirecta, para proponer, construir y reconstruir permanente-mente los sucesivos escenarios que semejante actividad precisa. Se trata de una propuesta dialéctica que integra al sujeto, bebé o niño pequeño, y a su contexto de desarrollo, en mutua y continua transformación, por lo que también resulta ser psicogenética. Empieza por cuidar el cuerpo y promover su bienestar y, sistemática-mente, vuelve a él a restaurarlo, para que en los ámbitos en los que el bebé o niño pequeño no necesita su colaboración, la función motriz y la actividad voluntaria, pueda descubrir, desplegar y desarrollar todas sus posibilidades, si así lo desea. Por todo ello en Lóczy, educar empieza por cuidar.

Estudio de la trabeculectomía experimental mediante implante de PLGA como dispositivo de liberación controlada de fármacos

225 p. : il.

1-42 beta-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death

1-42 beta-Amyloid (A beta(1-42)) peptide is a key molecule involved in the development of Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level. These morphological changes involve loss of neurites due to cytoskeleton alterations. However, the mechanism of A beta(1-42) peptide activation of the neurodegenerative program is still poorly understood. Here, A beta(1-42) peptide-induced transduction of cellular death signals through the phosphatidylinositol 3-kinase (PI3K)/phosphoinositol- dependent kinase (PDK)/novel protein kinase C (nPKC)/Rac 1 axis is described. Furthermore, pharmacological inhibition of PDK1 and nPKC activities blocks Rac 1 activation and neuronal cell death. Our results provide insights into an unsuspected connection between PDK1, nPKCs and Rac 1 in the same signal-transduction pathway and points out nPKCs and Rac 1 as potential therapeutic targets to block the toxic effects of A beta(1-42) peptide in neurons.

Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research

There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets. Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance. Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants) as well as the immunostimulatory effect of the formulation components (immunostimulants) modulates the immune response elicited. Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI) and effector and memory cell responses. This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages.

Optimization of solution-processed oligothiophene:fullerene based organic solar cells by using solvent additives

The optimization of solution-processed organic bulk-heterojunction solar cells with the acceptor-substituted quinquethiophene DCV5T-Bu-4 as donor in conjunction with PC61BM as acceptor is described. Power conversion efficiencies up to 3.0% and external quantum efficiencies up to 40% were obtained through the use of 1-chloronaphthalene as solvent additive in the fabrication of the photovoltaic devices. Furthermore, atomic force microscopy investigations of the photoactive layer gave insight into the distribution of donor and acceptor within the blend. The unique combination of solubility and thermal stability of DCV5T-Bu-4 also allows for fabrication of organic solar cells by vacuum deposition. Thus, we were able to perform a rare comparison of the device characteristics of the solution-processed DCV5T-Bu-4:PC61BM solar cell with its vacuum-processed DCV5T-Bu-4:C-60 counterpart. Interestingly in this case, the efficiencies of the small-molecule organic solar cells prepared by using solution techniques are approaching those fabricated by using vacuum technology. This result is significant as vacuum-processed devices typically display much better performances in photovoltaic cells. Keywords

De curas, frailes y monjas: disciplina y regulación del comportamiento del clero en el obispado de Calahorra, 1500-1700

25 p.

Ca2+ Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin (ACT) Endocytosis. Cell Physiology and Expression of the CD11b/CD18 Integrin Major Determinants of the Entry Route

Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and catalyzes the unregulated formation of cAMP, hampering important bactericidal functions of these immune cells that eventually cause cell death by apoptosis and/or necrosis. Additionally, ACT permeabilizes cells through pore formation in the target cell membrane. Recently, we demonstrated that ACT is internalised into macrophages together with other membrane components, such as the integrin CD11b/CD18 (CR3), its receptor in these immune cells, and GM1. The goal of this study was to determine whether ACT uptake is restricted to receptor-bearing macrophages or on the contrary may also take place into cells devoid of receptor and gain more insights on the signalling involved. Here, we show that ACT is rapidly eliminated from the cell membrane of either CR3-positive as negative cells, though through different entry routes, which depends in part, on the target cell physiology and characteristics. ACT-induced Ca2+ influx and activation of non-receptor Tyr kinases into the target cell appear to be common master denominators in the different endocytic strategies activated by this toxin. Very importantly, we show that, upon incubation with ACT, target cells are capable of repairing the cell membrane, which suggests the mounting of an anti-toxin cell repair-response, very likely involving the toxin elimination from the cell surface.