Cambios en las sinapsis del hipocampo de rata inducidos por el receptor de neurokinina 3 (NK3-R)

Mediante Western blot y cultivos celulares, en el presente trabajo se han observado las variaciones en el número de espinas dendríticas y sinapsis en neuronas del hipocampo de ratas macho de tres meses de edad, cuando se activa o se inhibe el receptor de neurokinina 3 (NK3-R) mediante drogas agonistas o antagonistas. Se ha visto que el gen de este receptor tiene una menor expresión en ratas muy ansiosas en comparación con las poco ansiosas, por lo que se pretende estudiar las implicaciones que pueda tener esta proteína en el trastorno de ansiedad.

Esperimentazioa Kimika Fisikoan Kimika graduko irakasgaiaren terminologia-glosategia egitea eta terminologia aztertzea

Lan honetan Kimika arloko euskarazko terminologia akademikoaren deskripzioan eta finkapenean ekarpen bat egin da UPV/EHUko Zientzia eta Teknologia Fakultateko Kimika graduan irakasten den Esperimentazioa Kimika Fisikoan irakasgaian erabiltzen den terminologia errealetik abiatuta. Terminologia Sareak Ehunduz (TSE) programan garatutako metodologia erabiliz bildu da terminologia eta euskara-gaztelania-ingelesa glosategi eleaniztun bat prestatu da Terminologia Zerbitzurako Online Sisteman (TZOS) kontsultagai jartzeko. Bestalde, bildutako terminologia erkatu da, batetik, aldez aurretik TZOSen jasota zegoen terminologiarekin eta, bestetik, Elhuyarren Zientzia eta Teknologiaren Hiztegi Entziklopedikoan eta Euskalterm datu-base terminologikoan kodifikatuta dagoenarekin. Egindako azterketak agerian utzi du Euskalterm datu-baseak glosategiko termino gehien jasotzen dituena dela (% 64,6), TZOSen terminoen erdia ageri direla (% 50,4) eta Elhuyarren ZT Hiztegi Entziklopedikoan, aldiz, erdia baino gutxiago (% 45,7) ageri direla. Azkenik, egindako glosategian bildutako terminologiaren azterketa linguistikoa egin da, irakasgai honetan erabiltzen den terminologiaren profila irudikatzeko helburuaz.

TRANSFER OF ANALYTICAL METHODS FOR THE CHARACTERISATION OF NATURAL PRODUCTS TO R&D PROCESSES OF IDOKI

IDOKI SCF Technologies S.L. is a technology-based company, set up on September 2006 in Derio (Biscay) with the main scope of developing extraction and purification processes based on the use of supercritical fluid extraction technology (SFE) in food processing, extraction of natural products and the production of personal care products. IDOKI¿s researchers have been working on many different R&D projects so far, most of them using this technology. However, the optimization of a SFE method for the different matrices cannot be performed unless we have an analytical method for the characterisation of the extracts obtained in each experiment. The analytical methods are also essential for the quality control of the raw materials that are going to be used and also for the final product. This PhD thesis was born to tackle this problem and therefore, it is based on the development of different analytical methods for the characterisation of the extracts and products. The projects that we could include in this thesis were the following: the extraction propolis, the recovery of agroindustrial residues (soy and wine) and the dealcoholisation of wine.On the one hand, for the extraction of propolis, several UV-Vis spectroscopic methods were used in order to measure the antioxidant capacity and the total polyphenol and flavonoid content of the extracts. A SFC method was also developed in order to measure more specific phenolic compounds. On the other hand, for the recovery of agroindustrial residues UV-Vis spectroscopy was used to determine the total polyphenol content and two SFC methods were developed to analyse different phenolic compounds. Extraction methods such as MAE, FUSE and rotary agitation were also evaluated for the characterisation of the raw materials.Finally, for the dealcoholisation of wine, the development of a SBSE-TD-GC-MS and DHS-TD-GC-MS methods for the analysis of aromas and a NIR spectroscopic method for the determination of ethanol content with the help of chemometrics was necessary. Most of these methods are typically used in IDOKI¿s lab as routine analyses apart from others not included in this PhD thesis.

Introducción al entorno R

R puede entenderse como un lenguaje de programación, como un potente software de análisis estadísticos o incluso como un generador de gráficos. Cualquiera de las tres acepciones es compatible con una definición de R. Estas páginas ofrecen al lector interesado y no iniciado en programación, los conceptos básicos y necesarios de la sintaxis de R que le permitirán trabajar en un entorno pensado para su uso con interfaces de códigos. Si bien es cierto que existen interfaces gráficas (R Commander) que facilitan el uso de R como software para el análisis de datos, no es menos cierto que la adquisición de destrezas en el manejo de unas normas de sintaxis básicas permitirán al usuario de R beneficiarse aún más de la potencia y de las ventajas que ofrece este entorno.

Psicometría. Conceptos básicos y aplicaciones prácticas con R Commander

El estudio de una escala de actitudes, un inventario de personalidad o una prueba de aptitud numérica comprende un conjunto de análisis cuya finalidad es garantizar la fiabilidad de los datos y la validez de las inferencias derivadas de ellos. El corpus que da sustento teórico, aplicado y ético a tales menesteres se cimienta sobre la disciplina denominada psicometría. La psicometría se ocupa del proceso de construcción y validación de escalas cuyo objetivo es medir variables de naturaleza psicológica. El libro trata en profundidad y de forma actualizada los dos grandes temas de la medición empírica, la fiabilidad y las validez, así como la tecnología implicada en su análisis: regresión simple y múltiple, análisis factorial, equiparación de puntuaciones, funcionamiento diferencial del ítem, análisis de varianza. Todo ello se aborda desde una doble perspectiva teórica y aplicada. La primera aporta las bases necesarias para su comprensión y la segunda contribuye a su asimilación por medio de un ejemplo real que se ilustra con la ayuda del mejor software disponible para el análisis de datos y la psicometría, R.

R Gizarte-zientzietarako. Datuen eta eskalen analisia Rcommander-ekin

Datuen analisi kuantitatiboa egin behar duen edonork, gaur egun, aukera zabala du. Programa ugari daude, komertzialak zein doakoak, edozein analisi mota, sinpleena zein konplexuena, egiteko. Programa komertzialen artean, SPSS, SAS, STATISTICA, Systat, Stata edo GenStat aipa daitezke. Programa horiek merkatu osoaz jabetu dira, eta Europako eta Amerikako unibertsitateetan analisi-tresna moduan erabiltzen dira. Programa horiek joan dira, lehenengo bertsioetatik gaurkoetaraino, interfaze grafikoak hobetuz (GUI Graphical User Interfaces) eta analisi-eredu gero eta konplexuagoak erantsiz. Leihoen kudeaketan oinarrituriko testuinguru-menuen eta goitik beherako menuen garapenari esker, programak erabilerrazagoak dira, eta analisi zein eredu formal konplexuenekin lan egiteko aukera izan du erabiltzaileen komunitateak.

Ugarteburu terminologia jardunaldiak (2010). Euskararen garapena esparru akademikoetan. Espezialitate hizkerak eta terminologia IV

I. Hitzaldia: - Andrés Alberdi (EIMA): EIMA eta ikasmaterialaren kalitatea. - Araceli Diaz de Lezana: Euskarazko terminologiaren normalizazioa: terminología batzordea. - Juan Garzia (EHU, Euskara Zerbitzua): EHUko Euskara Zerbitzua: ereduak ontzeko bideak lantzen. - Antton Gurrutxaga et alii (Elhuyar): Internet, corpusak eta terminología: Internetetik espezialitate-corpusak erauzteko teknikak eta horien ebaluazioa. - Josu Landa: Corpusen iraultza: maiztasunen korapiloa. - UZEI: Euskara juridikoa eta abokatuen hizkuntza-baliabideak. II. Komunikazioak: - Xabier Alberdi (EHU): Kalkoen eragina euskara akademikoaren garapen lexikoan: Lan Zuzenbideko terminología. - Kepa Altonaga (EHU): Arnaut Abadia (1843-1916), gure zientzia-prosaren aurrendari ahaztu bat. - Xabier Arregi, Ana Arruarte, Xabier Artola, Mikel Lersundi, Gotzon Santander eta Joseba Umbellina (IXA): TZOS: Terminologia Zerbitzurako On-line Sistema. - José Ramón Etxebarria (EHU): Matematika eta fisikako zenbait esamolde estandaritzateko proposamena. - Joseba Ezeiza (EHU): DB (Dokumentu Biltegia): corpus akademikoak sortzeko eta kudeatzeko azpiegitura teknologikoa. - Julio García García de los Salmones (EHU): Kalkoaren kontzeptua eta haren terminologia ikasliburuetan eta gramatiketan. - Jacinto Iturbe (EHU): Elementu kimikoen izenen formak hainbat hiztegitan eta gaur eguneko forma kanonikoak. - Itziar San Martín, Igone Zabala eta Joseba Ezeiza (EHU): Aditzetiko izenak erregistro-bereizle gisa: corpus espezializatu baten azterketa morfopragmatikoa. - Igone Zabala eta Agurtzane Elordui (EHU): Nominalizazioa estrategia diskurtsibo gisa: corpus akademikoaren azterketaren beharra.

Progressive Decrease in the Potential Usefulness of Meningococcal Serogroup B Vaccine (4CMenB, Bexsero (R)) in Gipuzkoa, Northern Spain

The effectiveness of a vaccine is determined not only by the immunogenicity of its components, but especially by how widely it covers the disease-causing strains circulating in a given region. Because vaccine coverage varies over time, this study aimed to detect possible changes that could affect vaccine protection during a specific period in a southern European region. The 4CMenB vaccine is licensed for use in Europe, Canada, and Australia and is mainly directed against Neisseria meningitidis serogroup B. This vaccine contains four main immunogenic components: three recombinant proteins, FHbp, Nhba and NadA, and an outer membrane vesicle [PorA P1.4]. The allelic distribution of FHbp, Nhba, NadA, and PorA antigens in 82 invasive isolates (B and non-B serogroups) isolated from January 2008 to December 2013 were analyzed. 4CMenB was likely protective against 61.8% and 50% of serogroup B and non-B meningococci, respectively, in the entire period, but between 2012 and 2013, the predicted protection fell below 45% (42.1% for serogroup B isolates). The observed decreasing trend in the predicted protection during the 6 years of the study (X-2 for trend = 4.68, p=0.03) coincided with a progressive decrease of several clonal complexes (e. g., cc11, cc32 and cc41/44), which had one or more antigens against which the vaccine would offer protection.

Possible antigravity regions in F (R) theory?

We construct an F(R) gravity theory corresponding to the Weyl invariant two scalar field theory. We investigate whether such F (R) gravity can have the antigravity regions where the Weyl curvature invariant does not diverge at the Big Bang and Big Crunch singularities. It is revealed that the divergence cannot be evaded completely but can be much milder than that in the original Weyl invariant two scalar field theory. (C) 2014 The Authors. Published by Elsevier B.V.

Carta enviada por R. Bozas Urrutia a Justo Garate en 1976

1 carta (mecanografiada) ; 215x155 mm

Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)-amino]acetyl}amino) benzophenone; a case of configurationally stable stereogenic nitrogen

A family of chiral ligands derived from alpha-phenylethylamine and 2-aminobenzophenone were prepared by alkylation of the nitrogen atom. Upon reaction with glycine and a Ni(II) salt, these ligands were transformed into diastereomeric complexes, as a result of the configurational stability of the stereogenic nitrogen atom. Different diastereomeric ratios were observed depending on the substituent R introduced in the starting ligand, and stereochemical assignments were based on X-ray analysis, along with NMR studies and optical rotation measurements.

Optimizing the Curie temperature of pseudo-binary RxR2-x ' Fe-17 (R, R ' = rare earth) for magnetic refrigeration

Several pseudo-binary RxR2-x'Fe-17 alloys (with R = Y, Ce, Pr, Gd and Dy) were synthesized with rhombohedral Th2Zn17-type crystal structure determined from x-ray and neutron powder diffraction. The choice of compositions was done with the aim of tuning the Curie temperature (T-C) in the 270 +/- 20 K temperature range, in order to obtain the maximum magneto-caloric effect around room temperature. The investigated compounds exhibit broad isothermal magnetic entropy changes, Delta S-M(T), with moderate values of the refrigerant capacity, even though the values of Delta S-M(Peak) are relatively low compared with those of the R2Fe17 compounds with R = Pr or Nd. The reduction on the Delta S-M(Peak) is explained in terms of the diminution in the saturation magnetization value. Furthermore, the Delta S-M(T) curves exhibit a similar caret-like behavior, suggesting that the magneto-caloric effect is mainly governed by the Fe-sublattice. A single master curve for Delta S-M/Delta S-M(Peak)(T) under different values of the magnetic field change are obtained for each compound by rescaling of the temperature axis.

Optika irakasgaiaren terminologia-hiztegi eleaniztuna egitea eta terminologia aztertzea

Lan honetan, Zientzia eta Teknologia Fakultatean eskaintzen den Fisikako Graduko irakas-materialetatik abiatuta, Optika irakasgaiko terminologia erreala detektatu eta hiztegi eleaniztun bat osatu da Terminologia Zerbitzurako Online Sisteman (TZOS) kontsultagai jartzeko. Terminologia Sareak Ehunduz (TSE) programarako garatuta- ko metodologia erabili da horretarako. Bestetik, sortutako hiztegia, eskura ditugun ohiko kontsulta-baliabideekin erkatu da, Optika irakasgaiko terminologiaren presentzia zenbaterainokoa den jakiteko. Azkenik, hiztegi eleaniztuna osatzen duten terminoen azterketa linguistikoa ere egin da, Optika irakasgaian erabilitako terminoen esanahiaren eta formaren profila irudikatzeko.

Quironómidos (Díptera) de las instalaciones de la E.D.A.R. de Galindo

[ES] La finalidad de este trabajo es la identificación taxonómica de algunos de los quironómidos (Diptera) presentes en el entorno de la Estación Depuradora de Aguas Residuales de Galindo. La captura de los insectos se llevó a cabo mediante dos metodologías distintas, en los clarificadores de Decantación Secundaria de la E.D.A.R. La identificación taxonómica se ha realizado con la consulta de guías de identificación de machos adultos, los cuales presentan características morfológicas diferenciadoras más útiles y complejas. La identificación llevó al establecimiento de cuatro morfotipos, que agrupan a los individuos observados según características morfológicas comunes. En cada morfotipo se incluyen los taxones correspondientes de acuerdo con su identificación taxonómica. Sin embargo, en algunos casos, la identificación no ha alcanzado el nivel de especie.

On the Stability and Equilibrium Points of Multistaged SI (n) R Epidemic Models

This paper relies on the concept of next generation matrix defined ad hoc for a new proposed extended SEIR model referred to as SI(n)R-model to study its stability. The model includes n successive stages of infectious subpopulations, each one acting at the exposed subpopulation of the next infectious stage in a cascade global disposal where each infectious population acts as the exposed subpopulation of the next infectious stage. The model also has internal delays which characterize the time intervals of the coupling of the susceptible dynamics with the infectious populations of the various cascade infectious stages. Since the susceptible subpopulation is common, and then unique, to all the infectious stages, its coupled dynamic action on each of those stages is modeled with an increasing delay as the infectious stage index increases from 1 to n. The physical interpretation of the model is that the dynamics of the disease exhibits different stages in which the infectivity and the mortality rates vary as the individual numbers go through the process of recovery, each stage with a characteristic average time.