55 resultados para Manuel, Juan


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Fecha: 29-10-1937/10-11-1937 (>1970 reproducción) / Unidad de instalación: Carpeta 45 - Expediente 1-9 / Nº de pág.: 3 (mecanografiadas)

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Fecha: 1974 / Unidad de instalación: Carpeta 48 - Expediente 8-6 / Nº de pág.: 3 (mecanografiadas)

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Fecha: 21-3-1940 (>1970 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-14 / Nº de pág.: 4 (mecanografiadas)

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Fecha: 1-1966 (>1970 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-20 / Nº de pág.: 3 (mecanografiadas)

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Fecha: 23-5-1937 (>1965 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-21 / Nº de pág.: 2 (mecanografiadas)

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Fecha: 27-12-1937/18-4-1938 / Unidad de instalación: Carpeta 45 - Expediente 2-26 / Nº de pág.: 4 (manuscritas)

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Presentado en las II. Jornadas de Lingüística Vasco-Románica / Euskal-Erromantze Linguistika II. Jardunaldietan aurkeztua (Bilbo, 2007)

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[EN]In the newEuropean higher education space, Universities in Europe are exhorted to cultivate and develop multilingualism. The European Commission’s 2004–2006 action plan for promoting language learning and diversity speaks of the need to build an environment which is favourable to languages. Yet reality indicates that it is English which reigns supreme and has become the main foreign language used as means of instruction at European universities. Internationalisation has played a key role in this process, becoming one of the main drivers of the linguistic hegemony exerted by English. In this paper we examine the opinions of teaching staff involved in English-medium instruction, from pedagogical ecologyof-language and personal viewpoints. Data were gathered using group discussion. The study was conducted at a multilingual Spanish university where majority (Spanish), minority (Basque) and foreign (English) languages coexist, resulting in some unavoidable linguistic strains. The implications for English-medium instruction are discussed at the end of this paper.

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Proiektu pilotu honekin medikuntzarako tresna lagungarri bat sortu da Jaiotzetiko Sortzen Diren Errore Metabolikoak (JASODEM) diagnostikatzeko. Horretarako, Gurutzeta Ospitaleko Metabolismo Laborategiko adituarekin eta UPV/EHUko Informatika Fakultateko ERABAKI taldearen arteko elkar-lana funtsezkoa izan da. Amaierako produktua Web zerbitzari batean egongo da exekutagarri. Web aplikazioaren bitartez, medikuak gaixo ezberdinei diagnostikoak egiteko aukera izango du. Horretarako aski da Praktika Klinikorako Gidaren exekuzio bat abiaraztea eta bertan pazienteari inguruan eskatzen diren datuak sartzea. Exekuzio prozesuan zehar badago sistematik irten eta ondoren lanarekin berriz jarraitzea, modu honetan froga klinikoak beharren arabera egiten direlarik, diagnostiko prozesuko kostua murriztuz. Bestalde, Praktika Klinikorako Gidan agertzen diren kontzeptuen inguruko informazioa jasotzeko funtzionalitatea eskaintzen zaio erabiltzaileari. Proiektua garatzeko aukeratu den metodologiaren jarraipen zehatza egitea eta kalitatezko dokumentazioa sortzea ezinbestekoa da. Proiektu honen garapenerako, Rational Unified Process (RUP) metodologia eta honi euskarria ematen dioten tresneria erabili da. Proiektuaren analisirako eta Jakintza Ingeniaritzarako CommonKADS metodologia erabili da.

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Ponencia leída en el Foro de Comunicaciones IkasArt II (BEC Barakaldo, 2010.06.17)

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This paper investigates the presence of limit oscillations in an adaptive sampling system. The basic sampling criterion operates in the sense that each next sampling occurs when the absolute difference of the signal amplitude with respect to its currently sampled signal equalizes a prescribed threshold amplitude. The sampling criterion is extended involving a prescribed set of amplitudes. The limit oscillations might be interpreted through the equivalence of the adaptive sampling and hold device with a nonlinear one consisting of a relay with multiple hysteresis whose parameterization is, in general, dependent on the initial conditions of the dynamic system. The performed study is performed on the time domain.

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Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala) variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods: The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls). Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results: Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%), seven were suspected of having hereditary CRC (2.8%) and 11 were controls (2.68%). There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both families. Only two positive cases of microsatellite instability (2/17, 11.8%) were detected in tumours from p.Lys618Ala carriers, indicating that this variant does not play a role in functional inactivation of MLH1 in CRC patients. Conclusions: The p.Lys618Ala variant should be considered a neutral variant for LS. These findings have implications for the clinical management of CRC probands and their relatives.

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1 carta (mecanografiada) ; 210x274 mm. Ubicación: Caja 1 - Carpeta 19