172 resultados para Grousacc, Pablo
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[ES] Para más información véase el trabajo LDGP_mem_003-2: "Estudio topográfico de las deformaciones del conjunto arquitectónico de la iglesia de Nuestra Señora de la Blanca (Agoncillo, La Rioja) [Julio 2007 – Octubre 2009]", http://hdl.handle.net/10810/7050
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[ES] La documentación contenida en este registro ha servido de base para las siguientes publicaciones:
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[ES] La documentación contenida en este registro ha servido de base para los siguientes documentos:
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[EN] Data contained in this record come from the following accademic activity (from which it is possible to locate additional records related with the Monastery):
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[ES] Tumba megalítica compuesta por 17 losas de gran tamaño, incluida la tapa. La estructura ocupa un espacio de 10 x 4 metros en planta, unos 4 metros de altura en la cámara. Conserva restos del túmulo que forma aproximadamente un círculo de unos 10 metros de radio.
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[ES] Los datos de este registro provienen de la una actividad académica que también aparece descrita en el repositorio y desde donde se puede acceder a otros trabajos relacionados con el Monasterio:
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Background: Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS patients is elevated, a feature which may be related to the pathophysiology of this disease. In addition to glutamate transporters, levels of extracellular glutamate are controlled by cystine/glutamate antiporter x(c)(-), an exchanger that provides intracellular cystine for production of glutathione, the major cellular antioxidant. The objective of this study was to analyze the role of the system x(c)(-) in glutamate homeostasis alterations in MS pathology. -- Methods: Primary cultures of human monocytes and the cell line U-937 were used to investigate the mechanism of glutamate release. Expression of cystine glutamate exchanger (xCT) was quantified by quantitative PCR, Western blot, flow cytometry and immunohistochemistry in monocytes in vitro, in animals with experimental autoimmune encephalomyelitis (EAE), the animal model of MS, and in samples of MS patients. -- Results and discussion: We show here that human activated monocytes release glutamate through cystine/glutamate antiporter x(c)(-) and that the expression of the catalytic subunit xCT is upregulated as a consequence of monocyte activation. In addition, xCT expression is also increased in EAE and in the disease proper. In the later, high expression of xCT occurs both in the central nervous system (CNS) and in peripheral blood cells. In particular, cells from monocyte-macrophage-microglia lineage have higher xCT expression in MS and in EAE, indicating that immune activation upregulates xCT levels, which may result in higher glutamate release and contribution to excitotoxic damage to oligodendrocytes. -- Conclusions: Together, these results reveal that increased expression of the cystine/glutamate antiporter system x(c)(-) in MS provides a link between inflammation and excitotoxicity in demyelinating diseases.
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Background: Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeutic effect in vitro and in vivo models. Method: We design in vitro and in vivo model. In vitro we used PLC and determine cell proliferation. In vivo, we used and animal model to determined, PCNA and MAT1A expression and transaminases levels. Results: We found that pravastatin decreases cell proliferation in vitro (cell proliferation in pravastatin group was 82%, in sorafenib group 51% and in combined group 40%) and in vivo (in pravastatin group 80%, in sorafenib group 76.4% and in combined group 72.72%). The MAT1A levels, was significantly higher in Pravastatin group (D 62%, P 94%, S 71%, P + S 91%). The transaminases levels, decreased significantly in Pravastatin group (GOT and GPT levels D 619.5 U/L; 271 U/L) (P 117.5 U/L; 43.5 U/L) (S 147 U/L; 59 U/L) (P + S 142 U/L; 59 U/L). Conclusion: The combination of pravastatin + sorafenib were more effective than Sorafenib alone.
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[ES] El seguimiento arqueológico se realiza sobre las capillas del la nave Norte de la iglesia más la capilla “de las reliquias”, en total 9 capillas de unos 10 x 10 metros cada una. Los elementos a documentar son las unidades estratigráficas exhumadas que, en gran medida corresponden a enterramientos (fosas y los propios esqueletos).
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[ES] Se trata de un área cubierta de unos 8 x 8 metros (la altura del techo es de unos 2,5 metros en la zona más baja) en la que se disponen varios huesos de diferentes especies entre los que destacan, por su porte, varios colmillos de elefante.
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[ES] Este proyecto corresponde a una continuación del que documenta la torre central y que se realizó en 2005. Dicho trabajo puede consultarse también es este repositorio:
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[EN] This correlational study aims to analyse the relationship of the social dimension of the selfconcept with age, educational level, sex and with the academic performance, understood as qualification and as artistic understanding of a group of primary and secondary students. The results show, generally, negative relationship between social self-concept and demographic variables, while statistically significant, although of opposite sign, of the social self-concept with the qualification in the field and with the artistic understanding respectively.
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[ES] Se trata de una explanada de unos 150 x 50 metros a las afueras del pueblo que antiguamente formaba un conjunto de eras empedradas (círculos de unos 20 metros de diámetro) de las cuales dos se han descubierto.
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[ES] Uno de los motivos de mayor peso que inducen a las organizaciones a la implantación de sistemas de gestión medioambiental es la presión ejercida por los grupos de interés. La investigación aporta resultados sobre cuál es la influencia de los grupos de interés sobre la gestión medioambiental. Con este fin hemos analizado 142 centros de negocio españoles, poseedores de los certificados ISO 14000 y/o EMAS, estableciendo la relación de los grupos de interés y su influencia con el modo en que se realiza en dichas organizaciones la gestión medioambiental.
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[EN] In the last decades, the topic of business ethics has attracted great interest at the academic and professional levels. Nowadays business ethics is being increasingly implemented as a necessary discipline in universities’ study plans on business management. Moreover, its importance is also evident according to the worldwide increase of organizations and/or institutions that have implemented ethics systems. However, some approaches thoroughly do not consider the importance and the need of an ethical behaviour and are still guiding the actions and the way of thinking of many academics and professionals led to consider that the only responsibility of business is limited just to profit maximization.