Regularizaci��n del cannabis en la C.A.V.

Este trabajo trata de un estudio profundo acerca del Cannabis y c��mo ha ido evolucionando esta sustancia a lo largo de la historia, no solo desde un punto de vista antropol��gico en cuanto a los diferentes usos que se le han ido dando en diversas sociedades y tiempos, sino tambi��n c��mo ha ido desarroll��ndose en materia legal y es ah�� donde centro mi objeto de estudio en la regularizaci��n del Cannabis

The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals

Colorectal cancer is one of the most frequent neoplasms and an important cause of mortality in the developed world. Mendelian syndromes account for about 5% of the total burden of CRC, being Lynch syndrome and familial adenomatous polyposis the most common forms. Lynch syndrome tumors develop mainly as a consequence of defective DNA mismatch repair associated with germline mutations in MLH1, MSH2, MSH6 and PMS2. A significant proportion of variants identified by screening these genes correspond to missense or noncoding changes without a clear pathogenic consequence, and they are designated as "variants of uncertain significance'', being the c.1852_1853delinsGC (p.K618A) variant in the MLH1 gene a clear example. The implication of this variant as a low-penetrance risk variant for CRC was assessed in the present study by performing a case-control study within a large cohort from the COGENT consortium-COST Action BM1206 including 18,723 individuals (8,055 colorectal cancer cases and 10,668 controls) and a case-only genotype-phenotype correlation with several clinical and pathological characteristics restricted to the Epicolon cohort. Our results showed no involvement of this variant as a low-penetrance variant for colorectal cancer genetic susceptibility and no association with any clinical and pathological characteristics including family history for this neoplasm or Lynch syndrome.

A chemically inert Rashba split interface electronic structure of C-60, FeOEP and PTCDA on BiAg2/Ag(111) substrates

The fields of organic electronics and spintronics have the potential to revolutionize the electronics industry. Finding the right materials that can retain their electrical and spin properties when combined is a technological and fundamental challenge. We carry out the study of three archetypal organic molecules in intimate contact with the BiAg2 surface alloy. We show that the BiAg2 alloy is an especially suited substrate due to its inertness as support for molecular films, exhibiting an almost complete absence of substrate-molecular interactions. This is inferred from the persistence of a completely unaltered giant spin-orbit split surface state of the BiAg2 substrate, and from the absence of significant metallic screening of charged molecular levels in the organic layer. Spin-orbit split states in BiAg2 turn out to be far more robust to organic overlayers than previously thought.

C@rol: Herramienta Web que aplica un nuevo m��todo para la mejora de la efectividad de grupos de estudiantes a trav��s de la identificaci��n de roles en entornos de aprendizaje colaborativo asistido por ordenador

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Estudio de una serie musteriense de La Quina (Charente, Francia): el ejemplo de la trinchera C (excavaciones DR. L. y G. Henri-Martin)

[ES] El an��lisis de una serie industrial correspondiente a los cinco niveles arqueol��gicos de la trinchera C de La Quina (Charente, Francia), proveniente de las excavaciones del Dr. L. Henri-Martin y de G. Henri-Martin, pone de manifiesto, junto a la caracterizaci��n del conjunto estratigr��fico por la presencia de raederas, el progresivo incremento de los denticulados en el devenir temporal. Este hecho asociado a otros particulares fen��menos secundarios (en el alargamiento de las formas, en la tipolog��a de las raederas, en la elaboraci��n del retoque, ... ) traducen una complicaci��n diacr��nica creciente en la din��mica de este complejo musteroide, presagiando, quiz��s, su relativa afinidad con el proceso leptolitizante de las series industriales evolucionadas del Paleol��tico medio.

T��cnicas de metalister��a en una moneda romana del siglo 1 d. C.

[ES] Se analiza un sestercio de Ner��n usado como elemento ornamental. Un artesano hizo en el reverso de la moneda algunos radios curvos y cinco agujeros. En el art��culo se hacen una serie de consideraciones sobre la realizaci��n de este inusual trabajo y su posible funci��n. Por otro lado, tambi��n se examinan ciertos aspectos de los usos ornamentales de la moneda y la evaluaci��n moral de la figura de Ner��n.