0-2 urteko haurren eskolatzea. Egokitzea ala etxekotzea?

[EUS] Azken urteetan eskolatze goiztiarrak nabarmen egin du gora gure gizartean. Gero eta gehiago dira hilabete gutxirekin haur eskolara joaten hasten diren haurrak, beraientzat segurtasun iturri den ingurunetik aldenduz. Banaketa hau bereziki zaila suerta dakieke ume gehienei aparteko ezinegonak, larritasun uneak edota gaixotasunak sortuz, eskolarekiko harremana betirako baldintzatzeaz gain. Hori dela eta, haur txikiaren eskolatzearen inguruan hausnartzeko beharra dago ezinbestean. Gaur egun haurra haur eskolako erritmo eta eskakizunetara ahalik eta azkarren moldatzeko asmoz, egokitzapen aldi bezala ezagutzen den denboraldia eskaintzen zaio haur txikiari, bere garaian Haur Hezkuntzaren bigarren ziklokoei eskaintzen hasi zitzaien bezala. Zoritxarrez honek egoerari zailtasun gehiago erantsi dizkio, ez baitira haurtxo eta haur txikiaren erritmoak errespetatzen. Hori dela eta, hezitzaileen muina eskola atsegina bihurtzeko asmotan, komunikazioan eta errespetuan oinarritutako etxekotze prozesua aurkezten da, zeinen helburua haurraren hezkuntzan parte hartzen duten guztien, familia eta eskola, elkarlanari esker bere ongizatea bermatu eta haur eskolarako igarobidea erraztuko duen giro lasaia, atsegina eta ez bakarrik adinari, baizik eta norberaren beharrizanen arabera egokia sortzea den.

La separación y el conflicto parental: efectos en las relaciones afectivas de los hijos adultos jóvenes.

323 p.

The scientific legacy of the "Instituto Eduardo Torroja" in Bilbao (1960-1980)

By means of this analysis, we have endeavored to evaluate and understand both the influence that the IETcc started to bear on scientific progress in Bilbao, mainly during the 1960s and the 1970s, as well as the determined efforts of the local financial and industrial elite of the time to transform Bilbao into the great metropolis of the north, i.e. the economic capital of that part of Spain, using as a model, among other metropolises, New York, the financial capital of America, and Pittsburg, the industrial capital. The various means to accomplish this have been studied: from the institutions of investigation, exposition and information which would initiate the longed for scientific progress, to the pathways for reproducing the fascinating American way.

Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles

Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in these RNA viruses are replaced by mRNA encoding antigens of interest as well as by RNA polymerase for replication and transcription. This kind of vaccine has been successfully assayed with many different antigens as vaccines candidates, and has been shown to be potent in several animal species, including mice, nonhuman primates, and humans. A key challenge to realizing the broad potential of self-amplifying vaccines is the need for safe and effective delivery methods. Ideally, an RNA nanocarrier should provide protection from blood nucleases and extended blood circulation, which ultimately would increase the possibility of reaching the target tissue. The delivery system must then be internalized by the target cell and, upon receptor-mediated endocytosis, must be able to escape from the endosomal compartment into the cell cytoplasm, where the RNA machinery is located, while avoiding degradation by lysosomal enzymes. Further, delivery systems for systemic administration ought to be well tolerated upon administration. They should be safe, enabling the multiadministration treatment modalities required for improved clinical outcomes and, from a developmental point of view, production of large batches with reproducible specifications is also desirable. In this review, the concept of self-amplifying RNA vaccines and the most promising lipid-based delivery systems are discussed.

Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results

Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular features of two well-known drugs, ie, rimonabant and fentanyl. The new compounds have been tested for their affinity and functionality regarding CB1 and CB2 cannabinoid and mu opioid receptors. In [S-35]-GTP.S (guanosine 5'-O-[gamma-thio] triphosphate) binding assays from the post-mortem human frontal cortex, they proved to be CB1 cannabinoid antagonists and mu opioid antagonists. Interestingly, in vivo, the new compounds exhibited a significant dual antagonist action on the endocannabinoid and opioid systems.

Novel Papillomaviruses in Free-Ranging Iberian Bats: No Virus-Host Co-evolution, No Strict Host Specificity, and Hints for Recombination

Papillomaviruses (PVs) are widespread pathogens. However, the extent of PV infections in bats remains largely unknown. This work represents the first comprehensive study of PVs in Iberian bats. We identified four novel PVs in the mucosa of free-ranging Eptesicus serotinus (EserPV1, EserPV2, and EserPV3) and Rhinolophus ferrumequinum (RferPV1) individuals and analyzed their phylogenetic relationships within the viral family. We further assessed their prevalence in different populations of E. serotinus and its close relative E. isabellinus. Although it is frequent to read that PVs co-evolve with their host, that PVs are highly species-specific, and that PVs do not usually recombine, our results suggest otherwise. First, strict virus-host co-evolution is rejected by the existence of five, distantly related bat PV lineages and by the lack of congruence between bats and bat PVs phylogenies. Second, the ability of EserPV2 and EserPV3 to infect two different bat species (E. serotinus and E. isabellinus) argues against strict host specificity. Finally, the description of a second noncoding region in the RferPV1 genome reinforces the view of an increased susceptibility to recombination in the E2-L2 genomic region. These findings prompt the question of whether the prevailing paradigms regarding PVs evolution should be reconsidered.

Bizkaiko jauntxoen inguruko herri literaturaz: Plentziako 1603ko hiru esaera zahar eta "Refranes y Sentencias"-en jatorria, eta proposamen bat Arrasateko erreketaren kantuez

[EUS] Lan honetan aurkikuntza baten berri ematen dugu: Plentziako armarri batean aurkitutako hiru euskal esaera zahar (1603) aurkezten eta hizkuntzaren eta historiaren ikuspuntutik aztertzen ditugu. Hiru esaerotatik bi «Refranes y sentencias» 1596) lanean agertzen dira, eta hori datu garrantzitsua da; izan ere, Lakarrak 1996) errefrau-bilduma anonimo horren jatorriaz egindako proposamena berresteko argudio berria da. Zehazki, Bizkaiko ipar-mendebala proposatu zuen Lakarrak bildumako errefrauen jatorri gisa. Beste alde batetik, Bizkaiko ipar-mendebaleko euskararen zenbait ezaugarri baliatuta, Arrasateko erreketari buruzko zenbait kantu eremu horretan sortu zirela proposatzen dugu —zehazki, Butroeko (Gatika) dorretxearen inguruan—, hizkuntzari dagozkion argudioak historiari buruzkoekin osatuta.

Euskal testu corpusa osatzen: J.P. Ulibarriren "Egunare eusquerazcoa erderascotic itzuliya"

[EUS] Artikulu honetan J. P. Ulibarri idazle okondoarrak 1815an argitaratu zuen "Egunare euskerazkoa erdaraskotik itzuliya" egutegia aurkezten dugu, urteetan galdutzat jo izan dena. Lan honetan, orain arte euskal bibliografoek "Egunare"-az esan dutena laburtu dugu (§1), eta horrekin batera alearen deskribapena eskaini dugu bai fisikoa eta baita gaien arabera(§2). Hirugarren atalean(§3), libarriren egiletasuna bermatu dugu: testua egile izenik gabe argitaratu bazen ere albaitariaren lantzat jo dugu, bere idaztankera eta euskara moldea aztertzeko lan honek duen garrantzia azpimarratuz. Amaitzeko, testua bera eskaini dugu, bai edizio erdipaleografiko legez eta baita faksimile eran.

Basque legacy in the New World: on the surnames of Latin American presidents

[EN] In this article we explain the etymology of the surnames of Basque origin that some presidents of Latin American countries have or have had in the past. These family names were created in the language called Euskara, in the Basque Country (Europe), and then, when some of the people who bore them emigrated to America, they brought their surnames with them. Most of the family names studied here are either oiconymic or toponymic, but it must be kept in mind that the oiconymic ones are, very often, based on house-nicknames, that is, they are anthroponymic in the first place. As far as possible, we have related the surname, when its origin is oiconymic or toponymic, to its source, i.e. to the house or place where it was created.

Erdi Aroko euskararen corpusa osatzeko ekarpena

[EUS] Lan honek Erdi Aroko euskararen ezagutzan sakontzeko ekarpena izan nahi du. Horretarako, garai hartako agirietan eta bestelakoetan agertzen diren hainbat lekukotasun bildu ditugu, bereziki leku eta pertsona izenak. Hauetarik batzuk lehendik ezagunak ziren Lacarrak (1957), Arzamendik (1985), Libanok (1995-1999) edo beste ikerlariek egindako lanei esker; guk honakoan guztiak biltzen saiatu gara, argitaragabe batzuk ere ekarri ditugu eta alfabetikoki hurrenkeratu ditugu eta intereseko datuak (urtea, herria, herrialdea, iturria eta bibliografia) eman ditugu. Bestalde, Erdi Aroko hilarrietan lekukotzen diren hilartitzetako euskarazko elementuak ere jaso eta aztertu ditugu.

Etymological notes on Aleut (III). With methodological notes on (Eskimo-Aleut) historical linguistics

[EN] The goal of this contribution is twofold: on the one hand, to review two relatively recent contributions in the field of Eskimo-Aleut historical linguistics in which it is proposed that Eskimo-Aleut languages are related genealogically to Wakashan (Holst 2004) and?/or Nostratic (Krougly-Enke 2008). These contributions can be characterized by saying that their authors have taken little care to be diligent and responsible in the application of the comparative method, and that their familiarity with the languages involved is insufficient. Eskimo-Aleut languages belong to a very exclusive group of language families that have been (and still are) used, sometimes compulsively, in the business of so-called “long-range comparisons”. Those carrying out such studies are very often unaware of the most basic facts regarding the philological and linguistic traditions of those languages, as a result of what mountains of very low quality works with almost no-relevancy for the specialist grow every year to the desperation of the scientific community, whose attitude toward them ranges from the most profound indifference to the toughest (and most explicit) critical tone. Since Basque also belongs to this group of “compare-with-everything-you-come- across” languages, it is my intention to provide the Basque readership with a sort of “pedagogical case” to show that little known languages, far from underrepresented in the field, already have a very long tradition in historical and comparative linguistics, i.e. nobody can approach them without previous acquaintance with the materials. Studies dealing with the methodological inappropriateness of the Moscow School’s Nostratic hypothesis or the incorrectness of many of the proposed new taxonomic Amerindian subfamilies (several of them involving the aforementioned Wakashan languages), that is to say, the frameworks on which Krougly-Enke and Holst work, respectively, are plenty (i.a. Campbell 1997: 260-329, Campbell & Poser 2008: 234-96), therefore there is no reason to insist once more on the very same point. This is the reason why I will not discuss per se Eskimo-Aleut–Wakashan or Eskimo-Aleut–Nostratic. On the contrary, I will focus attention upon very concrete aspects of Krougly-Enke and Holst´s proposals, i.e. when they work on “less ambitious” problems, for example, dealing with the minutiae of internal facts or analyzing certain words from the sole perspective of Eskimo-Aleut materials (in other words, those cases in which even they do not invoke the ad hoc help of Nostratic stuff). I will try to explain why some of their proposals are wrong, demonstrate where the problem lies, and fix it if possible. In doing so, I will propose new etymologies in an attempt at showing how we may proceed. The main difference between this and handbook examples lies in the reality of what we are doing: this is a pure etymological exercise from beginning to end. I will try to throw a bit of light on a couple of problematic questions regarding Aleut historical phonology, demonstrating how much work should be done at the lowest level of the Eskimo-Aleut pyramid; it is technically impossible to reach the peak of the pyramid without having completed the base. As far as Aleut is regarded, I will mainly profit not only from the use of the traditional philological analysis of Aleut (and, eventually, of Eskimo) materials, but also of diachronic typology, bringing into discussion what in my opinion seems useful, and in some cases I think decisive, parallels. It is worth noting that this paper makes up yet another part of a series of exploratory works dealing with etymological aspects of the reconstruction of Proto-Eskimo-Aleut, with special emphasis on Aleut (vid. i.a. Alonso de la Fuente 2006/2007, 2008a, 2008b, 2010a), whose main goal is to become the solid basis for an etymological dictionary of the Aleut language, currently in progress.

El acceso universitario de las jóvenes de origen magrebí en el País Vasco

En la sociedad vasca, como consecuencia de la globalización y de la intensificación de los movimientos poblacionales, ha ido en aumento el número de personas inmigrantes asentadas en este territorio. Uno de los colectivos cuya presencia más se ha incrementado en los últimos años es el de personas provenientes del Magreb. El hecho de que se trate cada vez en mayor medida de una inmigración permanente hace que sea necesario plantearse el tema de su integración a esta sociedad, sobre todo si tenemos en cuenta que tratándose de un colectivo cuyas raíces culturales y religiosas son muy distintas a las de la sociedad receptora, muchas veces son rechazados por parte de la población autóctona, a lo que se suma que en la mayoría de los casos forman parte de los estratos más bajos de la sociedad, lo cual incide en que puedan verse sumidos en la exclusión social. En este estudio, se parte de la idea de que en la actual sociedad de la información en la que nos encontramos inmersos la educación universitaria se torna cada vez más importante para la integración social de los individuos. En este sentido, y centrado en las hijas de los inmigrantes magrebíes, por sus características particulares de género y porque se estima que van a pasar su futuro en esta sociedad, a través de este trabajo se han analizado cuáles son los factores que dificultan y/o aventajan el acceso de las jóvenes de origen magrebí a educación superior universitaria en la sociedad vasca, tanto en su entorno socio-familiar como en la sociedad en general y en la institución educativa en particular, determinando si el género es una variable importante a la hora de definir dichas ventajas y/o dificultades; para ver con todo ello si realmente las jóvenes de origen magrebí se encuentran en situación de desigualdad en la sociedad vasca en torno al acceso a estudios universitarios.Con todo ello, y siendo este fenómeno relativamente reciente en el País Vasco, se pretende realizar un primer acercamiento a esta realidad que nos ayude a comprender mejor la futura integración de estas jóvenes a la sociedad vasca, la cual inserta en este mundo globalizado, cada vez es más compleja y se requieren mayores niveles de formación. De este modo, se pretende arrojar luz sobre esta realidad para encaminar futuras investigaciones sobre esta temática.

"Leioar" antroponimoaren lekuko toponimiko gehiago

[EN] The Basque anthroponym "Leioar" was analyzed by Alfonso Irigoien, which explained the origin of the name and the derived place names. In this paper we present new names derived, nine in total, the names are explained, also the appeared differences.

Las Asociaciones Estratégicas : El instrumento de política exterior de la Unión Europea frente al nuevo orden mundial

El presente trabajo realiza un análisis de las Asociaciones Estratégicas de la Unión Europea. Se tratan de un instrumento de política exterior de la Unión, para hacer frente al nuevo orden mundial. Por ello, el trabajo presenta el sistema internacional actual al que se enfrenta la Unión, analiza las Asociaciones Estratégicas (características, funciones y límites) y realiza un breve análisis de los 10 socios estratégicos con quienes se han establecido dichas asociaciones. El trabajo está redactado en castellano.

"Erran nahi baita" birformulatzaile esplikatiboa gaurko euskaran

[EN] This article presents a detailed study of the present-day use of the Basque discourse marker "erran/esan nahi baita" (‘that is to say’). This is an explanatory reformulator by means of which the speaker presents a reformulation of something said in the previous utterance (either a clause that forms part of the current sentence, or the preceding sentence) in order to express it more clearly or explain it. In the article I will examine the marker’s values; literary tradition; form and origin; present-day variants; equivalent expressions; position; punctuation; syntax; frequency, medium (written or spoken), register and text type; equivalents in other languages; and discourse value.