Software como un Servicio: Solución Business Intelligence

El propóosito del proyecto aquíı descrito radica en, por una parte, sentar una base de un sistema de Business Inteligence adaptable a diversos casos de negocio, y por otra, diseñar e implementar una solución completa para una empresa especíıfica fácilmente adaptable a otro caso, incluyendo desde los procesos de Extracción, Transformación y Carga, pasando por el data warehouse hasta el Business Analysis y la Minería de Datos.

Is there a subgroup of long-term evolution among patients with advanced lung cancer?: Hints from the analysis of survival curves from cancer registry data

Background: Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected population with advanced lung cancer to look for evidence of multimodality in survival distribution, and estimate the proportion of long-term survivors. Methods: We used survival data of 4944 patients with non-small-cell lung cancer (NSCLC) stages IIIb-IV at diagnostic, registered in the National Cancer Registry of Cuba (NCRC) between January 1998 and December 2006. We fitted one-component survival model and two-component mixture models to identify short-and long-term survivors. Bayesian information criterion was used for model selection. Results: For all of the selected parametric distributions the two components model presented the best fit. The population with short-term survival (almost 4 months median survival) represented 64% of patients. The population of long-term survival included 35% of patients, and showed a median survival around 12 months. None of the patients of short-term survival was still alive at month 24, while 10% of the patients of long-term survival died afterwards. Conclusions: There is a subgroup showing long-term evolution among patients with advanced lung cancer. As survival rates continue to improve with the new generation of therapies, prognostic models considering short-and long-term survival subpopulations should be considered in clinical research.

Metallic thin fi lms on stepped surfaces: lateral scattering of quantum well states

Quantum well states of Ag films grown on stepped Au(111) surfaces are shown to undergo lateral scattering, in analogy with surface states of vicinal Ag(111). Applying angle resolved photoemission spectroscopy we observe quantum well bands with zone-folding and gap openings driven by surface/interface step lattice scattering. Experiments performed on a curved Au(111) substrate allow us to determine a subtle terrace-size effect, i.e., a fine step-density-dependent upward shift of quantum well bands. This energy shift is explained as mainly due to the periodically stepped crystal potential offset at the interface side of the film. Finally, the surface state of the stepped Ag film is analyzed with both photoemission and scanning tunneling microscopy. We observe that the stepped film interface also affects the surface state energy, which exhibits a larger terrace-size effect compared to surface states of bulk vicinal Ag(111) crystals

Fast and Efficient Neural Conversion of Human Hematopoietic Cells

Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often slow, complex, and inefficient. We report a fast and efficient approach for generating induced neural cells (iNCs) directly from human hematopoietic cells using Sendai virus. Upon SOX2 and c-MYC expression, CD133-positive cord blood cells rapidly adopt a neuroepithelial morphology and exhibit high expansion capacity. Under defined neurogenic culture conditions, they express mature neuronal markers and fire spontaneous action potentials that can be modulated with neurotransmitters. SOX2 and c-MYC are also sufficient to convert peripheral blood mononuclear cells into iNCs. However, the conversion process is less efficient and resulting iNCs have limited expansion capacity and electrophysiological activity upon differentiation. Our study demonstrates rapid and efficient generation of iNCs from hematopoietic cells while underscoring the impact of target cells on conversion efficiency.

Valorization of scrap tires pyrolysis oil (STPO) through a 2-stage hydrotreating-hydrocracking strategy. Process variables and kinetic modeling

232 p.

Social, economic, and health impact of the respiratory syncytial virus: a systematic search

Background: Bronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection. Methods: A systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included. Results: The information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid-to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments). Conclusions: We concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid-and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations.

Modelización de procesos hidrológicos y de contaminación por nitratos mediante dos códigos numéricos (SWAT y MOHID). Cuenca agrícola del río Alegría (País Vasco)

245 p.+ anexos

La crítica de Ortega y Gasset a la modernidad y su lugar en la filosofía contemporánea. Problemas onto-epistemológicos

361 p.

Procesos microevolutivos en poblaciones de Sudamérica

308 p.

Análisis de la influencia del contexto familiar en el desarrollo cognitivo de niñas y niños de 4 años.

222 p. + anexos

Amniozentesiaren arriskuak eta teknika ez inbasiboak kromosomopatien detekziorako

SARRERA: Kromosomopatiei inguru gehiago ezagutzen doan heinean, hauek detektatzeko erabiltzen diren teknikak garatuz doaz. Detekzio teknikak bi taldeetan sailkatzen dira: teknika inbasiboak (amniozentesia, kordozentesia eta bellositate korionikoen azterketa) eta teknika ez inbasiboak (zelula edota azido nukleiko fetalen azterketa amaren odolean). HELBURUAK: Errebisio bibliografiko honen helburua amniozentesia eta froga ez inbasiboen deskribapena egitea da, baita hauen abantailak eta desabantailak deskribatzea. METODOLOGIA: Behin errebisio honen gaia zehaztuta egon zenean, bilaketa bibliografikoa egin zen Cochrane, PubMed eta beste datu baseetan. Ondoren, sartzeko eta baztertzeko irizpideak kontuan hartuta, artikuluen hautaketa egin zen. EMAITZAK: Amniozentesiaren teknikak hainbat arrisku dakar (abortua, amniorrea, lesioak fetuan, etab.) eta hauen portzentaiak altuak ez diren arren, haurdunaldian izan ahal dituzten ondorioak larriak dira. Bestalde, froga ez inbasiboen erabilpenen artean behin betiko diagnostikoa ezin da sartu hauen faltsu negatiboen tasa dela eta. Azkenik, erizaintzak rol garrantzitsua jokatzen du arlo honetan eta osasun langileek ezaguera eguneratuak izan beharko dituzte pazienteei informazio egokia emateko. ONDORIOAK: amniozentesiaren arrisku zerrenda luzea den arren, momentuz behin betiko diagnostikoa egiteko balio duen froga bakarra da (froga inbasiboekin batera) izan ere, froga ez inbasiboak momentuz ez daude prest behin betiko diagnostikoa egiteko.

Distrofia miotonikoa duten pazienteen eta euren senideen bizi-kalitatearen azterketa

Helburuak. Distrofia miotonikoan ematen diren sintomarik esanguratsuenak bildu, gaixoen eta senideen bizi-kalitatea aztertu eta osasunaren aldetik eman daitezkeen esku hartzeak aztertzea. Metodologia. Pubmed, Cochrane, ScienceDirect, Canadian Journal of Neuroscience Nursing (CJNN) eta hainbat erakunderen web orrialdeetan burututako bilaketa bibliografiko baten bidez, eta erreferentziazko pertsonekin kontaktuan jarriz, 14 artikulu, tesi bat, bost liburu eta hainbat web orrialderen bilaketa egin da. Konklusioak. Beharrezkoa da gaixotasun honen inpaktuaren azterketa sakonago bat burutzea. Alde fisiopatologikoa nahiko garatua dagoen arren, gaixotasuna pazienteen ikuspegitik aztertzeak atentziorako datu garrantzitsuak eman ditzake. Gaixotasun honen jarraipenerako gidak garatzen ari diren arren, oraindik asko dago gai honen inguruan egiteko.

Frame-level features conveying phonetic information for language and speaker recognition

150 p.

El teatro romano de Córdoba. Novedades en torno al edificio como fruto de los trabajos relacionados con su musealización (2006-2010)

[ES] Para más información sobre este trabajo, puede consultarse el registro: "Documentación geométrica de los restos del Teatro Romano de Córdoba", http://hdl.handle.net/10810/9167

Plastidic Phosphoglucose Isomerase Is an Important Determinant of Starch Accumulation in Mesophyll Cells, Growth, Photosynthetic Capacity, and Biosynthesis of Plastidic Cytokinins in Arabidopsis

Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. It is involved in glycolysis and in the regeneration of glucose-6-P molecules in the oxidative pentose phosphate pathway (OPPP). In chloroplasts of illuminated mesophyll cells PGI also connects the Calvin-Benson cycle with the starch biosynthetic pathway. In this work we isolated pgi1-3, a mutant totally lacking pPGI activity as a consequence of aberrant intron splicing of the pPGI encoding gene, PGI1. Starch content in pgi1-3 source leaves was ca. 10-15% of that of wild type (WT) leaves, which was similar to that of leaves of pgi1-2, a T-DNA insertion pPGI null mutant. Starch deficiency of pgi1 leaves could be reverted by the introduction of a sex1 null mutation impeding beta-amylolytic starch breakdown. Although previous studies showed that starch granules of pgi1-2 leaves are restricted to both bundle sheath cells adjacent to the mesophyll and stomata guard cells, microscopy analyses carried out in this work revealed the presence of starch granules in the chloroplasts of pgi1-2 and pgi1-3 mesophyll cells. RT-PCR analyses showed high expression levels of plastidic and extra-plastidic beta-amylase encoding genes in pgi1 leaves, which was accompanied by increased beta-amylase activity. Both pgi1-2 and pgi1-3 mutants displayed slow growth and reduced photosynthetic capacity phenotypes even under continuous light conditions. Metabolic analyses revealed that the adenylate energy charge and the NAD(P) H/NAD(P) ratios in pgi1 leaves were lower than those of WT leaves. These analyses also revealed that the content of plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP)-pathway derived cytokinins (CKs) in pgi1 leaves were exceedingly lower than in WT leaves. Noteworthy, exogenous application of CKs largely reverted the low starch content phenotype of pgi1 leaves. The overall data show that pPGI is an important determinant of photosynthesis, energy status, growth and starch accumulation in mesophyll cells likely as a consequence of its involvement in the production of OPPP/glycolysis intermediates necessary for the synthesis of plastidic MEP-pathway derived hormones such as CKs.