The acquisition of Tense and Aspect in Spanish

280 p.

Emulsion and miniemulsion polymerization stabilized with oligomeric surfactants (ASRs)

248 p.

La txalaparta digital: Un análisis de la txalaparta a través del desarrollo de software

239 p. + anexos

Contributions to time series data mining departing from the problem of road travel time modeling

194 p.

Differential activity of GSK-3 isoforms regulates NF-kappa B and TRAIL- or TNF alpha induced apoptosis in pancreatic cancer cells

While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apoptosis in PDA cell lines is enhanced by pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) or by shRNA-mediated depletion of either GSK-3 alpha or GSK-3 beta. In contrast, depletion of GSK-3 beta, but not GSK-3 alpha, sensitized PDA cell lines to TNF alpha-induced cell death. Further experiments demonstrated that TNF alpha-stimulated I kappa B alpha phosphorylation and degradation as well as p65 nuclear translocation were normal in GSK-3 beta-deficient MEFs. Nonetheless, inhibition of GSK-3 beta function in MEFs or PDA cell lines impaired the expression of the NF-kappa B target genes Bcl-xL and cIAP2, but not I kappa B alpha. Significantly, the expression of Bcl-xL and cIAP2 could be reestablished by expression of GSK-3 beta targeted to the nucleus but not GSK-3 beta targeted to the cytoplasm, suggesting that GSK-3 beta regulates NF-kappa B function within the nucleus. Consistent with this notion, chromatin immunoprecipitation demonstrated that GSK-3 inhibition resulted in either decreased p65 binding to the promoter of BIR3, which encodes cIAP2, or increased p50 binding as well as recruitment of SIRT1 and HDAC3 to the promoter of BCL2L1, which encodes Bcl-xL. Importantly, depletion of Bcl-xL but not cIAP2, mimicked the sensitizing effect of GSK-3 inhibition on TRAIL-induced apoptosis, whereas Bcl-xL overexpression ameliorated the sensitization by GSK-3 inhibition. These results not only suggest that GSK-3 beta overexpression and nuclear localization contribute to TNF alpha and TRAIL resistance via anti-apoptotic NF-kappa B genes such as Bcl-xL, but also provide a rationale for further exploration of GSK-3 inhibitors combined with TRAIL for the treatment of PDA.

Cuantificación y monitorización del hígado graso no alcohólico mediante resonancia magnética

133 p. + anexos

Development of osteoinductive Si-based coatings to improve dental implants' performance

290 p.

Revisión sistemática y metanálisis multivariado de la eficacia de potenciadores cognitivos en esquizofrenia

[287]p.

Hiztegigintza elebiduna: Euskara-Alemana

506 p., 44 p.

From Gods to men: A historical overview of the discovery of the chemical elements

To achieve the apparently simple Periodic Table of the Elements has implied tremendous efforts over thousands of years. In this paper we present a brief history of the discovery of the chemical elements from prehistory to the present day, revealing the controversies that arose on the way and claiming the important work performed by alchemists in the advancement of knowledge. This is especially important if we consider that alchemy had a period of existence of many thousands of years, while the "Chemistry", officially established as a science in the eighteenth century, has operated as such for only a few hundred years. Even so, if we consider the progress of discovery and isolation of chemical elements throughout history, it can be observed that the number of elements identified is achieved mainly in the nineteenth and twentieth centuries, reflecting the development of instrumental techniques, that facilitated this task.

Geochemical characterization of the fire-fountain fed deposits of Las Herrerias volcano (Campo de Calatrava Volcanic Field, Ciudad Real)

The Las Herrerias volcano (Bolanos de Calatrava, Campo de Calatrava Volcanic Field) is characterized by the great amount and variety of fire-fountain fed deposits. All these deposits are compositionally similar, being constituted by magnesium-rich (MgO = 11.58-4.19%), aluminium-poor (Al2O3 = 9.64-10.99%) highly sodic (Na2O = 2.24-3.81%) melanephelinites, with high contents in rare earth-elements (10x-200x chondrite), particularly in light-rare earth elements with respect to the heavy ones [(La/Lu)(N) = 32-35]. Contrary to the equivalent melanephelinites of this volcanic field, the relatively low contents in Ni (233-286 ppm), Cr (393-520 ppm) and magnesium number (Mg* = 45-54) indicate that these rocks do not correspond with primary melts. On the other hand, the variable distribution of clinopyroxene in the magma during eruption would be responsible for the slight compositional differences observed in the studied samples. Finally, we argue that these fire fountains were developed in a continental intraplate setting.

Del diseño a la programación de sistemas de control para la automatización de procesos industriales basados en PLC`s

Actualmente las mayoría de sistemas de automatización industrial utilizan los Autómatas Programables (PLC - Programmable Logic Controller) como sistemas de control y el diseño de dicho sistema se realiza mediante el lenguaje de modelado Grafcet. SFCEdit es un editor de Grafcet que permite el diseño de estos sistemas de control y la exportación de los mismos en un formato XML. Resumen Por otra parte tenemos la norma IEC 61131-3 que busca estandarizar los lenguajes de programación de los PLC de esta manera no se tendría que usar un lenguaje distinto por cada fabricante, y la organización PLCOpen rigiéndose por la norma ha creado un formato XML para cada lenguaje, en los cuales se basa el traductor. Resumen Habitualmente el paso del diseño a la programación se realiza de forma manual. La automatización de este proceso es el objetivo general del proyecto realizado. En esté se ha desarrollado una herramienta que permite realizar la traducción del diseño gráfico al estándar IEC 61131-3 considerando las particularidades de algunos fabricantes de PLCs como Beckhoff (TwinCAT) y TSX Micro (PL7Pro). Además la herramienta realiza la traducción al formato XML de PLCOpen. Resumen El traductor funciona recibiendo un fichero XML (exportado de SFCEdit) procesa su información y genera los ficheros en función de la compatibilidad que el usuario seleccione.

C@rol: Herramienta Web que aplica un nuevo método para la mejora de la efectividad de grupos de estudiantes a través de la identificación de roles en entornos de aprendizaje colaborativo asistido por ordenador

205 p.

Ecodiseño de alimentos mediante análisis de ciclo de vida

246 p.

Feedback systems for the quality of chest compressions during cardiopulmonary resuscitation

167 p.