3 resultados para Shaker K Channel

em CaltechTHESIS


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A search for dielectron decays of heavy neutral resonances has been performed using proton-proton collision data collected at √s = 7 TeV by the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) in 2011. The data sample corresponds to an integrated luminosity of 5 fb<sup>âˆ1</sup>. The dielectron mass distribution is consistent with Standard Model (SM) predictions. An upper limit on the ratio of the cross section times branching fraction of new bosons, normalized to the cross section times branching fraction of the Z boson, is set at the 95 % confidence level. This result is translated into limits on the mass of new neutral particles at the level of 2120 GeV for the Zâ² in the Sequential Standard Model, 1810 GeV for the superstring-inspired Zâ²<sub>ψ</sub> resonance, and 1940 (1640) GeV for Kaluza-Klein gravitons with the coupling parameter k/M<sub>Pl</sub> of 0.10 (0.05).

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<p>Several different methods have been employed in the study of voltage-gated ion channels. Electrophysiological studies on excitable cells in vertebrates and molluscs have shown that many different voltage-gated potassium (K<sup>+</sup>) channels and sodium channels may coexist in the same organism. Parallel genetic studies in Drosophila have identified mutations in several genes that alter the properties of specific subsets of physiologically identified ion channels. Chapter 2 describes molecular studies that identify two Drosophila homologs of vertebrate sodium-channel genes. Mutations in one of these Drosophila sodium-channel genes are shown to be responsible for the temperature-dependent paralysis of a behavioural mutant para<sup>ts</sup>. Evolutionary arguments, based on the partial sequences of the two Drosophila genes, suggest that subfamilies of voltage-gated sodium channels in vertebrates remain to be identified.</p> <p>In Drosophila, diverse voltage-gated K<sup>+</sup> channels arise from alternatively spliced mRNAs generated at the Shaker locus. Chapter 3 and the Appendices describe the isolation and characterization of several human K<sup>+</sup>-channel genes, similar in sequence to Shaker. Each of these human genes has a highly conserved homolog in rodents; thus, this K<sup>+</sup>-channel gene family probably diversified prior to the mammalian radiation. Functional K<sup>+</sup> channels encoded by these genes have been expressed in Xenopus oocytes and their properties have been analyzed by electrophysiological methods. These studies demonstrate that both transient and noninactivating voltage-gated K<sup>+</sup> channels may be encoded by mammalian genes closely related to Shaker. In addition, results presented in Appendix 3 clearly demonstrate that independent gene products from two K<sup>+</sup>-channel genes may efficiently co-assemble into heterooligomeric K<sup>+</sup> channels with properties distinct from either homomultimeric channel. This finding suggests yet another molecular mechanism for the generation of K<sup>+</sup>-channel diversity.</p>

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<p>A number of recent experiments have suggested the possibility of a highly inelastic resonance in K<sup>+</sup>p scattering. To study the inelastic K<sup>+</sup>p reactions, a 400 K exposure has been taken at the L.R.L. 25 inch bubble chamber. The data are spread over seven K<sup>+</sup> momenta between 1.37 and 2.17 GeV/c.</p> <p>Cross-sections have been measured for the reaction K<sup>+</sup>p â pK°Ï+ which is dominated by the quasi-two body channels K∠and K*N. Both these channels are strongly peripheral, as at other momenta. The decay of the ∠is in good agreement with the predictions of the rho-photon analogy of Stodolsky and Sakurai. The data on the K*p channel show evidence of both pseudo scalar and vector exchange.</p> <p>Cross-sections for the final state pK<sup>+</sup>Ï+Ï- shows a strong contribution from the quasi-two body channel K*âˆ. This reaction is also very peripheral even at threshold. The decay angular distributions indicate the reaction is dominated as at higher momenta by a pion exchange mechanism. The data are also in good agreement with the quark model predictions of Bialas and Zalewski for the K* and ∠decay.</p>