1 resultado para INNATE
em CaltechTHESIS
Filtro por publicador
- University of Cagliari UniCA Eprints (1)
- Aberdeen University (3)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (1)
- Aquatic Commons (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Aston University Research Archive (12)
- B-Digital - Universidade Fernando Pessoa - Portugal (5)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (9)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (54)
- Biblioteca Digital de la Universidad Católica Argentina (4)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (4)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (42)
- Brock University, Canada (5)
- Brunel University (1)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (6)
- CentAUR: Central Archive University of Reading - UK (43)
- Centro Hospitalar do Porto (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (92)
- Cochin University of Science & Technology (CUSAT), India (8)
- CORA - Cork Open Research Archive - University College Cork - Ireland (14)
- Cornell: DigitalCommons@ILR (1)
- Deakin Research Online - Australia (48)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (4)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (17)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (3)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (28)
- Indian Institute of Science - Bangalore - Índia (37)
- Instituto Gulbenkian de Ciência (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (6)
- Nottingham eTheses (6)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- QSpace: Queen's University - Canada (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (106)
- Queensland University of Technology - ePrints Archive (103)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (161)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (5)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- School of Medicine, Washington University, United States (3)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (3)
- Universidade de Lisboa - Repositório Aberto (3)
- Universidade dos Açores - Portugal (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Pará (6)
- Universidade Federal do Rio Grande do Norte (UFRN) (6)
- Universita di Parma (1)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (21)
- Université de Montréal (1)
- Université de Montréal, Canada (43)
- University of Michigan (2)
- University of Queensland eSpace - Australia (10)
- University of Washington (1)
- WestminsterResearch - UK (2)
Resumo:
The commensal microbiota impacts specific immune cell populations and their functions at peripheral sites, such as gut mucosal tissues. However, it remains unknown whether gut microbiota control immunity through regulation of hematopoiesis at primary immune sites. We reveal that germ-free mice display reduced proportions and differentiation potential of specific myeloid cell progenitors of both yolk sac and bone marrow origin. Homeostatic innate immune defects may lead to impaired early responses to pathogens. Indeed, following systemic infection with Listeria monocytogenes, germ-free and oral antibiotic-treated mice display increased pathogen burden and acute death. Recolonization of germ-free mice with a complex microbiota restores defects in myelopoiesis and resistance to Listeria. These findings reveal that gut bacteria direct innate immune cell development via promoting hematopoiesis, contributing to our appreciation of the deep evolutionary connection between mammals and their microbiota.