An Architecture forRepresenting Biological Processes based on Networks of Bio-inspired Processors

n this paper we propose the use of Networks of Bio-inspired Processors (NBP) to model some biological phenomena within a computational framework. In particular, we propose the use of an extension of NBP named Network Evolutionary Processors Transducers to simulate chemical transformations of substances. Within a biological process, chemical transformations of substances are basic operations in the change of the state of the cell. Previously, it has been proved that NBP are computationally complete, that is, they are able to solve NP complete problems in linear time, using massively parallel computations. In addition, we propose a multilayer architecture that will allow us to design models of biological processes related to cellular communication as well as their implications in the metabolic pathways. Subsequently, these models can be applied not only to biological-cellular instances but, possibly, also to configure instances of interactive processes in many other fields like population interactions, ecological trophic networks, in dustrial ecosystems, etc.

Integrated studies for the evaluation of conservation treatments on stone material from archaeological sites. Application to the case of Mérida (Spain)

In recent decades archaeological sites have been subject of many interventions. The application of conservation treatments, such us consolidation and protection ones by means of using, for instance, synthetic resins or organosilicic compounds, has been demonstrated inadequate in many cases, and even harmful for the heritage materials [1]. Evaluation studies should be a mandatory task, ideally before and after the intervention, but both tasks are complex and unusual in the case of archaeological heritage. Moreover, there is a general lack of knowledge in the mid and long term effects of these treatments, and how to act when these have resulted in deterioration of the original material. Remains of Roman Augusta Emerita, located in Merida (Spain), have gone through many interventions since the first archaeological campaign, in 1910. Some of them have demonstrated already to be harmful [2], others, more recent, must be evaluated in order to determine its effectiveness and durability, considering that many of these treatments are currently still applied. For this purpose a range of parameters has been measured such as color, surface hardness and roughness, mechanical or hydric properties, porosity, etc. on the original material (granite, marble and mortars mainly), and then the transformations of those same parameters analyzed after treatment, both in situ, in places where a intervention is documented, and in the laboratory, in samples. The study is being conducted both in the laboratory (Petrophysics Laboratory within IGEO) and in situ, on selected archaeological sites of Mérida (Theater and House of Mitreo). The comparison of results in untreated and treated areas of the site, and in treated-untreated samples, allows the distinction of variables that affect the interaction between products and stone material, issues such us effectiveness and durability of treatment and its validation or dismissal.

Formalisation and experiences of R2RML-based SPARQL to SQL query translation using Morph

R2RML is used to specify transformations of data available in relational databases into materialised or virtual RDF datasets. SPARQL queries evaluated against virtual datasets are translated into SQL queries according to the R2RML mappings, so that they can be evaluated over the underlying relational database engines. In this paper we describe an extension of a well-known algorithm for SPARQL to SQL translation, originally formalised for RDBMS-backed triple stores, that takes into account R2RML mappings. We present the result of our implementation using queries from a synthetic benchmark and from three real use cases, and show that SPARQL queries can be in general evaluated as fast as the SQL queries that would have been generated by SQL experts if no R2RML mappings had been used.

Atlas visual de cincuenta y siete años de arquitectura

En 1929 aparece el primer número de AA (L’architecture d’aujourd’hui), en 1932 existe un número-Monografía sobre los hermanos Perret, escrita por Pierre Vago, en 1946 se consolida como revista mensual y bajo la fundación de Andre Bloc. El primer número de AA que tengo en mi biblioteca es el número 34 (febrero-Marzo) de 1951. Mediante la lectura observada de una colección como AA, la determinación de unos capítulos representativos y la elección de imágenes de su tiempo se explican estos 57 años de arquitectura, cuyos resultados de un proceso temporal disfrutamos desde hace aproximadamente veinte años. A principio de los años cincuenta un grupo de jóvenes arquitectos, denso e intercomunicado en los congresos CIAM se propone situar la realidad de la arquitectura en los principios y realidades de su tiempo y de los que se intuyen futuro. Resultados de la Segunda Gran Guerra no son solo tragedias humanas sino gran investigación y desarrollo concretada industrialmente, enormes movimientos de personas en Europa y una sociedad enormemente optimista en USA, todo esto producirá las grandes transformaciones sociales de los 60’ y sus concreciones tecnológicas, políticas y desarrollo. Muchos arquitectos, publicaciones, concursos o decisiones políticas o privadas han producido el catalogo de arquitecturas de estos años, desde el CIAM IX hasta el POMPIDOU, desde la casa GEHRY hasta el KUNSTHAL, desde BRASILIA hasta SIDNEY, desde COPLEJIDAD Y CONTRADICCIÓN hasta DELIRIOS DE NY, desde OSAKA hasta MUNICH. En todas han existido un esfuerzo enorme por concretar la realidad de nuestras aspiraciones desde las puramente ideológicas de introspección social, hasta las concreciones de imagen directa. Varias líneas he abierto en mi proceso de investigación, las he llamado “anillos” porque todas estas líneas tienen similitud con los “anillos de crecimiento” de los árboles en cuanto a como se presentan en la estructura de formación y ha la cantidad de información no solo interna sino externa que aportan sobre la estructura árbol, su medio y la historia. Igual que podemos saber las temperaturas o las pluviometría que cubrieron Europa en la edad media solo estudiando los anillos de crecimiento de nuestro árboles (su grosor), de igual forma repasando LOS CONCURSOS y sus resultados que existieron en los últimos cincuenta años, podemos entender las aspiraciones y concreciones de las sociedades y sus arquitectos en este tiempo. Cuatro capítulos, los mas determinantes son los elegidos para dar cuerpo a una TESIS de tamaño capaz: Las ideas, el futuro, las referencias y el presente son los capítulos que de forma visual intentan explicar el fruto arquitectónico, sus aspiraciones y sus concreciones. Las ideas sin ninguna duda, pertenecen a los padres de nuestro tiempo, son las del Team X, la reflexión sobre lo perecedero, las realidades programáticas, densidades o lo publico-privado son solo planetas en el universo de sus ideas. El futuro lo trazaron aquellos que empezaron a investigar, concretar o reflexionar sobre la incidencia tanto de los procesos industriales con sus nuevos materiales como de las nuevas concreciones urbanas que los movimientos migratorios producirían en las ciudades. Las referencias son las bibliotecas de carácter informativo-visual que han generado nuestro inventario icónico. El presente son las imágenes de referencia de nuestro tiempo-mediático, no solo las produce un arquitecto (en este caso R.Koolhas), pero si que es verdad que en las imágenes arquitectónicas de OMA se concreta todo el catalogo de arquitecturas del presente. ENGLISH SUMMARY The fisrt AA (l´Architecture d´Aujourd´hui) issue was published in 1929, three years later, in 1932, a monographic issue on Perret brothers was written by Pierre Vago and in 1946 the magazine was strongly established as a monthly publication under the direction of André Bloc. The oldest copy I own on my bookshelves is nº 34 printed in February-March 1951. While carefully reading a collection such as AA we are able to extract representative chapters and images that can explain a linear process lasting 57 years of fruitful architectural production of which consequences we have been enjoying the past twenty years. In the early fifties a compact group of young architects linked by the CIAM congress decided to encompass architectural reality to the needs and principles of their time. Not only big human tragedies arose from the Second World War but also some of the fastest industrial inventions due to a powerful will to development, that altogether with european migrations and a high standard of optimism in the United States headed to the peak transformations of the sixties and their technological and political development. A bunch of architects, magazines and architectural competitions sided by political and private decisions produced the architectural catalogue of those years, from CIAM IX to the Pompidou art centre, from Gerhy´s house to the Kunsthal museum, from Brasilia to Sidney, from “Complexity and Contradiction“ to “Delirious NY” and from Osaka all the way to Munich. All of them carried a vast effort towards the concretion of will, from social introspection to a more effective development of images. Several paths run across my investigation, namely “the rings”, as they tend to behave as a growing structure like a tree trunk, providing internal and external information not only of the vegetal element but also of the environment and events crossing its time. In the same direction as we are able to predict the weather in the Middle Age by means of studying our forests, we can use the architectural competitions ant their results for the past fifty years to understand the will and ambitions of these developing societies and their architects. To give shape to a sizeable thesis the selected information has been packed in four chapters: Ideas, Future, References and Present, each of them structured as an Image bank visualizing the architectural product, its will and specific ambition. The first group, Ideas, is devoted entirely to the step-fathers of present architecture, with ideas that belong to TEAM X and embrace the reflection about the transitory, the programmatic reality, density or the public-private debate as wandering planets of their ideal universe. The second group is dedicated to a Future that was traced by those engaged on industrial processes and new material investigation together with some others exploring new urban concretions brought to existence by the pressure of the after war migrations. The third group, References, have been shaped as a stock-list containing all our iconic cross-references. The last group, Present, brings together the icons of this media-time we live in and not only those produced by one single architect (Rem Koolhaas) even if his production embodies all architectural references at the moment.

A machine learning approach to identify clinical trials involving nanodrugs and nanodevices from ClinicalTrials.gov

BACKGROUND: Clinical Trials (CTs) are essential for bridging the gap between experimental research on new drugs and their clinical application. Just like CTs for traditional drugs and biologics have helped accelerate the translation of biomedical findings into medical practice, CTs for nanodrugs and nanodevices could advance novel nanomaterials as agents for diagnosis and therapy. Although there is publicly available information about nanomedicine-related CTs, the online archiving of this information is carried out without adhering to criteria that discriminate between studies involving nanomaterials or nanotechnology-based processes (nano), and CTs that do not involve nanotechnology (non-nano). Finding out whether nanodrugs and nanodevices were involved in a study from CT summaries alone is a challenging task. At the time of writing, CTs archived in the well-known online registry ClinicalTrials.gov are not easily told apart as to whether they are nano or non-nano CTs-even when performed by domain experts, due to the lack of both a common definition for nanotechnology and of standards for reporting nanomedical experiments and results. METHODS: We propose a supervised learning approach for classifying CT summaries from ClinicalTrials.gov according to whether they fall into the nano or the non-nano categories. Our method involves several stages: i) extraction and manual annotation of CTs as nano vs. non-nano, ii) pre-processing and automatic classification, and iii) performance evaluation using several state-of-the-art classifiers under different transformations of the original dataset. RESULTS AND CONCLUSIONS: The performance of the best automated classifier closely matches that of experts (AUC over 0.95), suggesting that it is feasible to automatically detect the presence of nanotechnology products in CT summaries with a high degree of accuracy. This can significantly speed up the process of finding whether reports on ClinicalTrials.gov might be relevant to a particular nanoparticle or nanodevice, which is essential to discover any precedents for nanotoxicity events or advantages for targeted drug therapy.

Innovations in the video game industry: changing global markets

The paper examines the video game industry in the perspective of being the paradigm of innovation in digital media and content. In particular, it analyses the response to two main factors that have impacted this industry over the last decade. First, it tracks the evolution of its global market and its emerging geography with the rise of Asia. Second, within this global landscape the paper explores how the changes derived from mobile and on-line gaming enabled major transformations of this industry. From here, some conclusions on the lessons from the evolution of this sector for the whole media and content industries are presented.

Las mineralizaciones auríferas de Galicia Occidental en la Zona de Cizalla Busto-Limideiro (A Coruña)

Las mineralizaciones de oro de Galicia Occidental ligadas a grandes estructuras comienzan a ser interpretadas de manera más rigurosa, al mismo tiempo que la continuada elevación de las cotizaciones del oro han hecho más atractiva la reactivación de áreas hasta ahora casi olvidadas. El propósito de esta investigación participa de las razones anteriores. La zona de cizalla Busto Limideiro se inscribe en una de estas estructuras, la cizalla Santa Comba-Punta Langosteira, con la que se relacionan un importante número de yacimientos auríferos entre los que destacan Corcoesto y Monte Piñor. Por su situación geológica, estos indicios se enmarcan en el Macizo Ibérico, en la Zona de Galicia Tras-os-Montes. Este trabajo aporta más conocimiento sobre un modelo general del oro de los yacimientos del noroeste español, integrándolo en los yacimientos de oro orogénico del Varisco europeo. Este estudio ha supuesto un importante esfuerzo investigador centrado sobre de los procesos genéticos que han dado lugar a las mineralizaciones auríferas. Los estudios petrográficos, metalogénicos, geoquímicos, microtemométricos y el análisis de isótopos han permitido establecer un modelo general y otros más específicos sobre la existencia y condiciones de formación en la concentración del oro mineralógico. De esta forma se ha caracterizado su mineralogía, quimismo, edad, y naturaleza de los paleofluidos que han intervinieron en su formación. De los resultados obtenidos se destaca que estas mineralizaciones se encuentran fuertemente ligadas a las estructuras y transformaciones físicas y químicas de las rocas afectadas por la banda de cizalla. Derivada de esta situación, se comprende la disposición espacial, a diversas escalas, con estructuras claramente en la transición del dominio dúctil a frágil. Además, resulta evidente, a escala macro y microscópica, el emplazamiento preferente del oro en estructuras de deformación miloníticas. Los estudios anteriores posibilitan formalizar un modelo de génesis para el yacimiento de Monte Piñor que resulta compatible con el establecido por Groves (1998), e incluirlas en un mismo contexto, como yacimientos de oro orogénico mesotermales, válido para el conjunto de todos los de la zona de cizalla Busto Limideiro. El estudio no omite la consideración geoestadística de este yacimiento, justificando la elección de direcciones de anisotropía explicadas por consideraciones de carácter estructural. Con ello, buscando el lado práctico desde el punto de vista minero, esta investigación propone líneas generales de aplicación de actuación con sentido de exploración, contribuyendo a la puesta en valor del conocimiento de las mineralizaciones de oro del noroeste español. ABSTRACT Old and nearly forgotten gold mines from Western Galicia are currently attractive to be recovered due to both, the new strict interpretation of gold mineralization linked to Variscan large structures and the increasing gold prices. The shear zone Busto Limiderio is relevant as a part of a Variscan large structure, Santa Comba-Punta Langosteira, which is related with a high number of gold deposits as Corcoesto and Monte Piñor. For its geological situation, these signs are part of the Iberian Massif in the area of Galicia Tras-os-Montes. Hence, the main aim of this study is to provide additional and important knowledge of Busto Limiderio about the general model of gold deposits in the Spanish northwest, integrating them in the orogenic gold deposits of European Variscan, enabling to analyze the economic recovery possibility of this area. This thesis has been focused on the genetic processes that have led to the gold mineralization. Petrographic studies, metalogenic, geochemical, microthermometric and isotope analysis have allowed to establish a general and specific models about the existence and training conditions in the concentration of mineralogical gold. Consequently, the mineralogy, chemical characteristics, age, and nature of paleofluids that have participated in its formation have been characterized. The results showed that Busto Limiderio gold mineralization are strongly linked to the structures and physical and chemical transformations of affected rocks by the shear band. The mineralization spatial distribution at various scales is due to the link with the large structures in the ductile-to-brittle transition domain. Furthermore, this factor determine at macro and microscopic scale, the preferred location of the gold structures mylonitic deformation. Previous studies have permitted to establish a model of genesis for the site of Monte Piñor which is compatible with the established by Groves (1998), and also to include them in the same context as mesothermal orogenic gold deposits, valid throughout all of Busto Limideiro shear zone. This study does not omit consideration of the geostatistical deposit, justifying the choice of directions of anisotropy explained by structural considerations. This thesis concludes with general action guidelines for mining exploration, contributing to the enhancement of knowledge of Spanish gold mineralization northwest.

Road to 1966 : caminos hacia "complejidad y contradicción en la arquitectura", en la cultura arquitectónica de la segunda posguerra en EE.UU

Complejidad y contradicción en la arquitectura ha resultado ser una de las referencias capitales más aludidas, citadas y reproducidas de la literatura arquitectónica de los tiempos recientes. No en vano, en la introducción de la propia obra, Vincent Scully afirmó que «probablemente es el texto más importante sobre arquitectura desde ‘Vers une Architecture’, escrito por Le Corbusier en 1923». Sin embargo, sus fuentes parece que están inexploradas o, al menos, no examinadas. Por ello, Road to 1966 se plantea como un trabajo de investigación con tres objetivos de partida fundamentales: (1) el interés en estudiar el debate arquitectónico candente, creado con las fricciones surgidas entre los protagonistas de unos años que cambiaron el estado de lo que se consideraba una obra legítima en arquitectura; (2) se pretende ampliar la cronología del desarrollo intelectual de un texto, el de Venturi, que marcó la segunda mitad del siglo xx, de manera retroactiva hasta los años de la II Guerra Mundial, cuando parece que empezaban a ser coherentes y reconocibles unas nuevas posiciones desde las que aproximarse a las cuestiones de la práctica, la teoría y la historia de la arquitectura; (3) poder ofrecer una nueva interpretación de dicho texto de Venturi, entendido no como el origen primigenio de parte de las grandes transformaciones de la arquitectura reciente (de los últimos cincuenta años), sino como el resultado necesario de esa cronología intelectual previa. La arquitectura norteamericana de estos años de posguerra ha resultado ser crucial en su posterior desarrollo, y, especialmente, en relación al libro de Venturi. De hecho, Scully en la introducción de la edición original de Complejidad y contradicción, señalaba que «el principal argumento del libro está expuesto a finales de los cincuenta». Que la arquitectura del siglo xx tiene en la Norteamérica de los años sesenta -cuando se consolida la figura de Venturi- uno de sus capítulos más decisivos, frecuentemente asumido como el paso siguiente a la importada modernidad heroica europea, hoy parece no ser discutido por casi nadie. Ahora bien: ¿qué ocurre con los años intermedios? ¿Qué acontece entre el final de la II Guerra Mundial y esos años sesenta? La posible carencia de una postura dominante y clara quizás haya sumido esta etapa en un cierto olvido o descuido por parte de historiadores y críticos. Así, este trabajo se estructura alrededor del papel que ocupa el texto venturiano, sin ser éste su único protagonista. Tomado más bien como excusa, la tesis va profundizando de manera deductiva en el conjunto de circunstancias que pudieron llevar a su autor hacia las conclusiones que desarrolló, detectando los ambientes biográficos y formativos, pensamientos compartidos e influencias epistemológicas y profesionales mutuas, que justificarían una novedosa interpretación de dicho texto como el corolario necesario de un panorama de crisis y cambios - éste sí protagonista en este trabajo-, al contrario de cómo habitualmente se ha venido entendiendo dicha obra. La investigación se centra predominantemente en el rastreo de las fuentes citadas por el propio Venturi en su libro, así como de los textos de mayor difusión (generalmente revistas profesionales no exclusivamente académicas, además de libros, catálogos de exposiciones, actas de simposios…), y no tanto en las obras construidas o proyectadas; sí, quizás, en los términos en los que dichas obras fueron publicadas, comentadas o reseñadas. Así, se ha adoptado una aproximación concebida sub specie bibliotecae, donde se han aplicado unos métodos de trabajo caracterizados por su componente cronológica, y, después, analítico-comparativa: dicho de otro modo, un método historiográfico-periodístico capaz de relacionar las historias o cursos de ciertas ideas o nociones, dentro de un contexto general más amplio en sus derivadas arquitectónicas, estéticas, socio-generacionales, culturales, filosóficas, científicas, políticas, literarias… Con ello, se pretende establecer una relectura del primer libro de Venturi y sus años de gestación desde unas nuevas concepciones, más modernas que postmodern(ist)as, proponiendo una posible evolución en la arquitectura más reciente cuyas raíces, a fin de cuentas, tendrían su origen en la Norteamérica de 1946 a 1966. ABSTRACT Complexity and Contradiction in Architecture has proved to be one of the capital, alluded references cited and reproduced in the architectural literature of the recent times. Not surprisingly, in the Introduction to the book, Vincent Scully wrote that "yet it is probably the most important writing on the making of architecture since Le Corbusier´s ‘Vers une Architecture’, of 1923". However, its sources seem to be unexplored or at least not examined. Therefore, Road to 1966 is presented as a research with three fundamental starting objectives: (1) first, the interest in studying the burning architectural debate, created within the arising frictions among the protagonists of the years that changed the status of what was considered a legitimate work in architecture; (2) second, it seeks to extend the chronology of the intellectual background of the book written by Venturi, which marked the second half of the twentieth century, in a retroactive manner to the years of the World War II, when it seems that some new positions from which to approach the issues of practice, theory and history of architecture began to be consistent and recognizable; (3) lastly, to offer a new interpretation of Venturi’s text, now understood not as the primal source of the great transformations of the recent architecture (of the last fifty years), but as the necessary result of that background intellectual chronology. The American architecture of these post-war years has proved to be crucial in its later stages, and especially in relation to the book of Robert Venturi. In fact, Scully in the Introduction to the first edition of Complexity and Contradiction, noted that "the major argument of this book was laid out in the late fifties". The fact that the architecture of the twentieth century –when the leading figure of Venturi was consolidated- has in the North America of the sixties one of its most decisive chapters, (often assumed as the next step to the imported European heroic modernism) today seems to be discussed by almost anyone. Now, what about the intervening years? What happens between the end of the World War II and the sixties? The potential lack of a clear dominant position of this stage may have plunged it into oblivion or oversight by historians and critics. Thus, this research is structured around the role that occupies Venturi’s work, whereas this is not its only subject. Rather taken as an excuse, the thesis deepens deductively in the set of circumstances that could lead its author to the conclusions he developed in 1966, detecting biographical and academic environments, shared thoughts and epistemological and mutual professional influences, that would justify a new interpretation of this book as a necessary corollary of an outlook of crisis and change (this major and center subject in this dissertation), contrary to what has been commonly understood upon this work. The research focuses predominantly on tracing the sources cited by Venturi himself in his book, as well as other texts of wider dissemination and outreach (usually professional journals not exclusively academic, as well as books, catalogs of exhibitions, symposia proceedings...), and not so much in the buildings or unbuilt projects; but also, perhaps, it is focused in the terms in which these works were published, commented or reviewed. Hence an approach conceived sub specie bibliotecae has been adopted, with working methods characterized by their chronological component, and then the analytical-comparative one: in other words, a historiographicaljournalistic method able to relate stories or courses of certain ideas or notions, within a broader general context in its architectural, aesthetic, sociological-generational, cultural, philosophical, scientific, political, literary... sides. This approach intends to establish a re-reading of Venturi’s first book and its years of gestation, from some new understandings, more modern than postmodern(ist), proposing a possible evolution of the latest architecture whose roots, after all, would have their origin in the North America of 1946-1966.