Analysis of spontaneous MEG activity in mild cognitive impairment and Alzheimer's disease using spectral entropies and statistical complexity measures

Alzheimer's disease (AD) is the most common cause of dementia. Over the last few years, a considerable effort has been devoted to exploring new biomarkers. Nevertheless, a better understanding of brain dynamics is still required to optimize therapeutic strategies. In this regard, the characterization of mild cognitive impairment (MCI) is crucial, due to the high conversion rate from MCI to AD. However, only a few studies have focused on the analysis of magnetoencephalographic (MEG) rhythms to characterize AD and MCI. In this study, we assess the ability of several parameters derived from information theory to describe spontaneous MEG activity from 36 AD patients, 18 MCI subjects and 26 controls. Three entropies (Shannon, Tsallis and Rényi entropies), one disequilibrium measure (based on Euclidean distance ED) and three statistical complexities (based on Lopez Ruiz–Mancini–Calbet complexity LMC) were used to estimate the irregularity and statistical complexity of MEG activity. Statistically significant differences between AD patients and controls were obtained with all parameters (p < 0.01). In addition, statistically significant differences between MCI subjects and controls were achieved by ED and LMC (p < 0.05). In order to assess the diagnostic ability of the parameters, a linear discriminant analysis with a leave-one-out cross-validation procedure was applied. The accuracies reached 83.9% and 65.9% to discriminate AD and MCI subjects from controls, respectively. Our findings suggest that MCI subjects exhibit an intermediate pattern of abnormalities between normal aging and AD. Furthermore, the proposed parameters provide a new description of brain dynamics in AD and MCI.

Speed-independent gait identification for mobile devices

Due to the intensive use of mobile phones for diferent purposes, these devices usually contain condential information which must not be accessed by another person apart from the owner of the device. Furthermore, the new generation phones commonly incorporate an accelerometer which may be used to capture the acceleration signals produced as a result of owner s gait. Nowadays, gait identication in basis of acceleration signals is being considered as a new biometric technique which allows blocking the device when another person is carrying it. Although distance based approaches as Euclidean distance or dynamic time warping have been applied to solve this identication problem, they show di±culties when dealing with gaits at diferent speeds. For this reason, in this paper, a method to extract an average template from instances of the gait at diferent velocities is presented. This method has been tested with the gait signals of 34 subjects while walking at diferent motion speeds (slow, normal and fast) and it has shown to improve the performance of Euclidean distance and classical dynamic time warping.

Procedimiento multicriterio-multiobjetivo de planificación energética a comunidades rurales aisladas

La toma de decisiones en el sector energético se torna compleja frente a las disímiles opciones y objetivos a cumplir. Para minimizar esta complejidad, se han venido desarrollando una gama amplia de métodos de apoyo a la toma de decisiones en proyectos energéticos. En la última década, las energización de comunidades rurales aisladas ha venido siendo prioridad de muchos gobiernos para mitigar las migraciones del campo para la ciudad. Para la toma de decisiones en los proyectos energéticos de comunidades rurales aisladas se necesitan proyectar la influencia que estos tendrás sobre los costes económicos, medioambientales y sociales. Es por esta razón que el presente trabajo tuvo como objetivo diseñar un modelo original denominado Generación Energética Autóctona Y Limpia (GEAYL) aplicado a una comunidad rural aislada de la provincia de Granma en Cuba. Este modelo parte dos modelos que le preceden el PAMER y el SEMA. El modelo GEAYL constituye un procedimiento multicriterio-multiobjetivo de apoyo a la planificación energética para este contexto. Se plantearon cinco funciones objetivos: F1, para la minimización de los costes energéticos; F2 para la minimización de las emisiones de CO2, F3, para la minimización de las emisiones de NOx; F4, para la minimización de las emisiones de SOx (cuyos coeficientes fueron obtenidos a través de la literatura especializada) y F5, para la maximización de la Aceptación Social de la Energía. La función F5 y la manera de obtener sus coeficientes constituye la novedad del presente trabajo. Estos coeficientes se determinaron aplicando el método AHP (Proceso Analítico Jerárquico) con los datos de partidas derivados de una encuesta a los usuarios finales de la energía y a expertos. Para determinar el suministro óptimo de energía se emplearon varios métodos: la suma ponderada, el producto ponderado, las distancias de Manhattan L1, la distancia Euclidea L2 y la distancia L3. Para estas métricas se aplicaron distintos vectores de pesos para determinar las distintas estructuras de preferencias de los decisores. Finalmente, se concluyó que tener en consideración a Aceptación Social de la Energía como una función del modelo influye en el suministro de energía de cada alternativa energética. ABSTRACT Energy planning decision making is a complex task due to the multiple options to follow and objectives to meet. In order to minimize this complexity, a wide variety of methods and supporting tools have been designed. Over the last decade, rural energization has been a priority for many governments, aiming to alleviate rural to urban migration. Rural energy planning decision making must rely on financial, environmental and social costs. The purpose of this work is to define an original energy planning model named Clean and Native Energy Generation (Generación Energética Autóctona Y Limpia, GEAYL), and carry out a case study on Granma Province, Cuba. This model is based on two previous models: PAMER & SEMA. GEAYL is a multiobjective-multicriteria energy planning model, which includes five functions to be optimized: F1, to minimize financial costs; F2, to minimize CO2 emissions; F3, to minimize NOx emissions; F4, to minimize SOx emissions; and F5, to maximize energy Social Acceptability. The coefficients corresponding to the first four functions have been obtained through specialized papers and official data, and the ones belonging to F5 through an Analytic Hierarchy Process (AHP), built as per a statistical enquiry carried out on energy users and experts. F5 and the AHP application are considered to be the novelty of this model. In order to establish the optimal energy supply, several methods have been applied: weighted sum, weighted product, Manhattan distance L1, Euclidean distance L2 and L3. Several weight vectors have been applied to the mentioned distances in order to conclude the decision makers potential preference structure. Among the conclusions of this work, it must be noted that function F5, Social Acceptability, has a clear influence on every energy supply alternative.

Después de Einstein: una arquitectura para una teoría

En 1905, aparecen en la revista "Annalen der physik" tres artículos que revolucionarán las ciencias físicas y pondrán en jaque los asentados conceptos newtonianos de Espacio y Tiempo. La formulación de la Teoría de la Relatividad por Albert Einstein pone en crisis el valor absoluto de estos conceptos, y permite proponer nuevas reflexiones a propósito de su concepción dentro del campo de la física. Esta revolución ¿podría extrapolarse al campo de la arquitectura, donde Espacio y Tiempo tienen un papel protagonista? Hay que entender la complejidad del hecho arquitectónico y las innumerables variables que participan de su definición. Se estudia en esta Tesis Doctoral un aspecto muy concreto: cómo un paradigma (la Teoría de la Relatividad) puede intervenir y modificar, o no, la Arquitectura. Se plantea para ello ir al origen; desentrañar el momento de interacción entre la Teoría de la Relatividad y la Teoría de la Arquitectura, que permita determinar si aquella influyó sobre ésta en los escritos teóricos de las vanguardias aplicados a la Arquitectura. “Después de Einstein. Una arquitectura para una teoría” buscará los puntos de conexión de la Teoría de la Relatividad con la teoría arquitectónica de las vanguardias de principio del siglo XX, su influencia, la contaminación entre una y otra, con posibles resultados arquitectónicos a partir de esta interacción, capaz de definir nuevos argumentos formales para un nuevo lenguaje enArquitectura. Annalen der physik Después de Einstein. Una arquitectura para una teoría Para ello la Tesis se estructura en cuatro capítulos. El primero expone el ámbito geográfico y cronológico donde se desarrolla la Teoría de la Relatividad con la repercusión teórica que tiene para el arte, en función de una nueva definición de espacio vinculado al tiempo, como evento que se desarrolla en un ámbito cuatridimensional; la indeterminación de las medidas de espacio y de las medidas de tiempo, y la importancia de entender la materia como energía. El segundo capítulo estudia los movimientos de vanguardia coetáneos a la eclosión de la Relatividad, enmarcados en su ámbito geográfico más próximo. El cubismo se muestra como movimiento que participa ocasionalmente de las matemáticas y la geometría, bajo el influjo del científico Henri Poincaré y las geometrías no euclidianas. El futurismo indaga en los avances de la ciencia desde una cierta lejanía, cierta falta de rigor o profundidad científica para extraer las leyes de su nuevo idealismo plástico constructivo, definiendo e interpretando su Universo a partir de los avances de la ciencia, en respuesta a la crisis del espacio y del tiempo newtonianos. El lenguaje científico se encuentra presente en conceptos como "simultaneidad" (Boccioni), "expansión esférica de la luz en el espacio" (Severini y Carrá), "cuatridimensionalidad", "espacio-tiempo", "aire-luz-fuerza", "materia y energía" que paralelamente conforman el cuerpo operacional de la teoría de Einstein. Si bien no es posible atribuir a la Teoría de la Relatividad un papel protagonista como referente para el pensamiento artístico, en 1936, con la aparición del manifiesto Dimensionista, se atribuyen explícitamente a las teorías de Einstein las nuevas ideas de espacio-tiempo del espíritu europeo seguido por cubistas y futuristas. El tercer capítulo describe cómo la Teoría de la Relatividad llegó a ser fuente de inspiración para la Teoría de la Arquitectura. Estructurado en tres subcapítulos, se estudia el autor principal que aportó para la Arquitectura conceptos e ideas extrapoladas de la Teoría de la Relatividad después de su estudio e interpretación (Van Doesburg), dónde se produjeron las influencias y puntos de contacto (Lissitzky, Eggeling, Moholy-Nagy) y cómo fueron difundidas a través de la arquitectura (Einsteinturm de Mendelsohn) y de las revistas especializadas. El cuarto capítulo extrae las conclusiones del estudio realizado en esta Tesis, que bien pudiera resumir MoholyNagy en su texto "Vision inmotion" (1946) al comentar: "Ya que el "espacio-tiempo" puede ser un término engañoso, tiene que hacerse especialmente hincapié en que los problemas de espacio-tiempo en el arte no están necesariamente basados en la Teoría de la Relatividad de Einstein. Esto no tiene intención de descartar la relevancia de su teoría para las artes. Pero los artistas y los laicos rara vez tienen el conocimiento matemático para visualizar en fórmulas científicas las analogías con su propio trabajo. La terminología de Einstein del "espacio-tiempo" y la "relatividad" ha sido absorbida por nuestro lenguaje diario." ABSTRACT. "AFTER EINSTEIN:ANARCHITECTUREFORATHEORY." In 1905, three articles were published in the journal "Annalen der Physik ". They revolutionized physical sciences and threw into crisis the newtonian concepts of Space and Time. The formulation of the Theory of Relativity by Albert Einstein put a strain on the absolute value of these concepts, and proposed new reflections about them in the field of Physics. Could this revolution be extrapolated to the field of Architecture, where Space and Time have a main role? It is necessary to understand the complexity of architecture and the countless variables involved in its definition. For this reason, in this PhD. Thesis, we study a specific aspect: how a paradigm (Theory of Relativity) can intervene and modify -or not- Architecture. It is proposed to go back to the origin; to unravel the moment in which the interaction between the Theory of Relativity and the Theory of Architecture takes place, to determine whether the Theory of Relativity influenced on the theoretical avant-garde writings applied to Architecture. "After Einstein.An architecture for a theory " will search the connection points between the Theory of Relativity and architectural avant-garde theory of the early twentieth century, the influence and contamination between them, giving rise to new architectures that define new formal arguments for a new architectural language. Annalen der Physik This thesis is divided into four chapters. The first one describes the geographical and chronological scope in which the Theory of Relativity is developed showing its theoretical implications in the field of art, according to a new definition of Space linked to Time, as an event that takes place in a fourdimensional space; the indetermination of the measurement of space and time, and the importance of understanding "matter" as "energy". The second chapter examines the avant-garde movements contemporary to the theory of relativity. Cubism is shown as an artist movement that occasionally participates in mathematics and geometry, under the influence of Henri Poincaré and non-Euclidean geometries. Futurism explores the advances of science at a certain distance, with lack of scientific rigor to extract the laws of their new plastic constructive idealism. Scientific language is present in concepts like "simultaneity" (Boccioni), "expanding light in space" (Severini and Carra), "four-dimensional space", "space-time", "light-air-force," "matter and energy" similar to the operational concepts of Einstein´s theory. While it is not possible to attribute a leading role to the Theory of Relativity, as a benchmark for artistic laws, in 1936, with the publication of the Dimensionist manifest, the new ideas of space-time followed by cubist and futurist were attributed to the Einstein's theory. The third chapter describes how the Theory of Relativity became an inspiration for the architectural theory. Structured into three subsections, we study the main author who studied the theory of relativity and ,as a consequence, contributed with some concepts and ideas to the theory of architecture (Van Doesburg), where influences and contact points took place (Lissitzky, Eggeling, Moholy-Nagy) and how were disseminated throughArchitecture (Einsteinturm, by Mendelsohn) and journals. The fourth chapter draws the conclusions of this PhD. Thesis, which could be well summarized by Moholy Nagy in his text "Vision in Motion" (1946): vi Since "space-time" can be a misleading term, it especially has to be emphasized that the space-time problems in the arts are not necessarily based upon Einstein´s Theory of Relativity. This is not meant to discount the relevance of his theory to the arts. But artists and laymen seldom have the mathematical knowledge to visualize in scientific formulae the analogies to their own work. Einstein's terminology of "space-time" and "relativity" has been absorbed by our daily language.

Criteria for Positioning Active Multilateration Stations Located Close to Distance Measuring Equipment

The need for the use of another surveillance system when radar cannot be used is the reason for the development of the Multilateration (MLT) Systems. However, there are many systems that operate in the L-Band (960-1215MHz) that could produce interference between systems. At airports, some interference has been detected between transmissions of MLT systems (1030MHz and 1090MHz) and Distance Measuring Equipment (DME) (960-1215MHz).

On the Mahalanobis Distance Classification Criterion for Multidimensional Normal Distributions

Many existing engineering works model the statistical characteristics of the entities under study as normal distributions. These models are eventually used for decision making, requiring in practice the definition of the classification region corresponding to the desired confidence level. Surprisingly enough, however, a great amount of computer vision works using multidimensional normal models leave unspecified or fail to establish correct confidence regions due to misconceptions on the features of Gaussian functions or to wrong analogies with the unidimensional case. The resulting regions incur in deviations that can be unacceptable in high-dimensional models. Here we provide a comprehensive derivation of the optimal confidence regions for multivariate normal distributions of arbitrary dimensionality. To this end, firstly we derive the condition for region optimality of general continuous multidimensional distributions, and then we apply it to the widespread case of the normal probability density function. The obtained results are used to analyze the confidence error incurred by previous works related to vision research, showing that deviations caused by wrong regions may turn into unacceptable as dimensionality increases. To support the theoretical analysis, a quantitative example in the context of moving object detection by means of background modeling is given.

Improving shortest paths in the Delaunay triangulation

We study a problem about shortest paths in Delaunay triangulations. Given two nodes s; t in the Delaunay triangulation of a point set P, we look for a new point p that can be added, such that the shortest path from s to t in the Delaunay triangulation of P u{p} improves as much as possible. We study properties of the problem and give efficient algorithms to find such a point when the graph-distance used is Euclidean and for the link-distance. Several other variations of the problem are also discussed.

Time derivatives in air temperature and enthalpy as non-invasive welfare indicators during long distance animal transport in Spain and Portugal.

High temperatures and relative humidity can compromise animal welfare on the farm level, but less is known about those changes during long distance transport of domestic animals to slaughter. Although upper temperature limits have been established to transport pigs in Europe, few indices include relative or absolute humidity maxima or mention appropriate enthalpy ranges.

Electrical Power Fluctuations in a Network of DC/AC inverters in a Large PV Plant: relationship between correlation, distance and time scale

This paper analyzes the correlation between the fluctuations of the electrical power generated by the ensemble of 70 DC/AC inverters from a 45.6 MW PV plant. The use of real electrical power time series from a large collection of photovoltaic inverters of a same plant is an impor- tant contribution in the context of models built upon simplified assumptions to overcome the absence of such data. This data set is divided into three different fluctuation categories with a clustering proce- dure which performs correctly with the clearness index and the wavelet variances. Afterwards, the time dependent correlation between the electrical power time series of the inverters is esti- mated with the wavelet transform. The wavelet correlation depends on the distance between the inverters, the wavelet time scales and the daily fluctuation level. Correlation values for time scales below one minute are low without dependence on the daily fluctuation level. For time scales above 20 minutes, positive high correlation values are obtained, and the decay rate with the distance depends on the daily fluctuation level. At intermediate time scales the correlation depends strongly on the daily fluctuation level. The proposed methods have been implemented using free software. Source code is available as supplementary material.

Effect of substrate-target distance and sputtering pressure in the synthesis of AlN thin films

In this work, we analyze the influence of the processing pressure and the substrate–target distance on the synthesis by reactive sputtering of c-axis oriented polycrystalline aluminum nitride thin films deposited on Si(100) wafers. The crystalline quality of AlN has been characterized by high-resolution X-ray diffraction (HR-XRD). The films exhibited a very high degree of c-axis orientation especially when a low process pressure was used. After growth, residual stress measurements obtained indirectly from radius of curvature measurements of the wafer prior and after deposition are also provided. Two different techniques are used to determine the curvature—an optically levered laser beam and a method based on X-ray diffraction. There is a transition from compressive to tensile stress at a processing pressure around 2 mTorr. The transition occurs at different pressures for thin films of different thickness. The degree of c-axis orientation was not affected by the target–substrate distance as it was varied in between 30 and 70 mm.

A new procedure for race analysis in swimming based on individual distance measurements

biomecanica de la natación

Sight distance for traffic safety analysis using GIS

Sight distance is of major importance for road safety either when designing new roads or analysing the alignment of existing roads. It is essential that available sight distance in roads is long enough for emergency stops or overtaking manoeuvres. Also, it is vital for engineers/researchers that the tools used for that analysis are both powerful and intuitive. Based on ArcGIS, the application to be presented not only performs an exhaustive sight distance calculation, but allows an accurate analysis of 3D alignment, using all new tools, from a Digital Elevation Model and vehicle trajectory. The software has been successfully utilised to analyse several two-lane rural roads in Spain. In addition, the software produces thematic maps representing sight distance in which supplementary information about crashes, traffic flow, speed or design consistency could be included, allowing traffic safety studies.

Sight distance studies on roads: influence of digital elevation models and roadside elements

Sight distance plays an important role in road traffic safety. Two types of Digital Elevation Models (DEMs) are utilized for the estimation of available sight distance in roads: Digital Terrain Models (DTMs) and Digital Surface Models (DSMs). DTMs, which represent the bare ground surface, are commonly used to determine available sight distance at the design stage. Additionally, the use of DSMs provides further information about elements by the roadsides such as trees, buildings, walls or even traffic signals which may reduce available sight distance. This document analyses the influence of three classes of DEMs in available sight distance estimation. For this purpose, diverse roads within the Region of Madrid (Spain) have been studied using software based on geographic information systems. The study evidences the influence of using each DEM in the outcome as well as the pros and cons of using each model.

Comparison of starts and turns of national and regional level swimmers by individualized-distance measurements

The aim of this study was to compare the race characteristics of the start and turn segments of national and regional level swimmers. In the study, 100 and 200-m events were analysed during the finals session of the Open Comunidad de Madrid (Spain) tournament. The “individualized-distance” method with two-dimensional direct linear transformation algorithm was used to perform race analyses. National level swimmers obtained faster velocities in all race segments and stroke comparisons,although significant inter-level differences in start velocity were only obtained in half (8 out of 16) of the analysed events. Higher level swimmers also travelled for longer start and turn distances but only in the race segments where the gain of speed was high. This was observed in the turn segments, in the backstroke and butterfly strokes and during the 200-m breaststroke event, but not in any of the freestyle events. Time improvements due to the appropriate extension of the underwater subsections appeared to be critical for the end race result and should be carefully evaluated by the “individualized-distance” method.

Strategies for Minimum Distance in Simulated Evacuation of Transport Airplanes

The present paper describes the preliminary stages of the development of a new, comprehensive model conceived to simulate the evacuation of transport airplanes in certification studies. Two previous steps were devoted to implementing an efficient procedure to define the whole geometry of the cabin, and setting up an algorithm for assigning seats to available exits. Now, to clarify the role of the cabin arrangement in the evacuation process, the paper addresses the influence of several restrictions on the seat-to-exit assignment algorithm, maintaining a purely geometrical approach for consistency. Four situations are considered: first, an assignment method without limitations to search the minimum for the total distance run by all passengers along their escaping paths; second, a protocol that restricts the number of evacuees through each exit according to updated FAR 25 capacity; third, a procedure which tends to the best proportional sharing among exits but obliges to each passenger to egress through the nearest fore or rear exits; and fourth, a scenario which includes both restrictions. The four assignment strategies are applied to turboprops, and narrow body and wide body jets. Seat to exit distance and number of evacuees per exit are the main output variables. The results show the influence of airplane size and the impact of non-symmetries and inappropriate matching between size and longitudinal location of exits.