Branching angles of pyramidal cell dendrites follow common geometrical design principles in different cortical areas

Unraveling pyramidal cell structure is crucial to understanding cortical circuit computations. Although it is well known that pyramidal cell branching structure differs in the various cortical areas, the principles that determine the geometric shapes of these cells are not fully understood. Here we analyzed and modeled with a von Mises distribution the branching angles in 3D reconstructed basal dendritic arbors of hundreds of intracellularly injected cortical pyramidal cells in seven different cortical regions of the frontal, parietal, and occipital cortex of the mouse. We found that, despite the differences in the structure of the pyramidal cells in these distinct functional and cytoarchitectonic cortical areas, there are common design principles that govern the geometry of dendritic branching angles of pyramidal cells in all cortical areas.

Explicitly Context-Aware Publish/Subscribe with Context-Invariant Subscriptions

Although context could be exploited to improve the performance, elasticity and adaptation in most distributed systems that adopt the publish/subscribe (P/S) model of communication, only very few works have explored domains with highly dynamic context, whereas most adopted models are context agnostic. In this paper, we present the key design principles underlying a novel context-aware content-based P/S (CA-CBPS) model of communication, where the context is explicitly managed, focusing on the minimization of network overhead in domains with recurrent context changes thanks to contextual scoping. We highlight how we dealt with the main shortcomings of most of the current approaches. Our research is some of the first to study the problem of explicitly introducing context-awareness into the P/S model to capitalize on contextual information. The envisioned CA-CBPS middleware enables the cloud ecosystem of services to communicate very efficiently, in a decoupled, but contextually scoped fashion.

Oscillatory genetic circuits: new designs and mathematical models

Introduction and motivation: A wide variety of organisms have developed in-ternal biomolecular clocks in order to adapt to cyclic changes of the environment. Clock operation involves genetic networks. These genetic networks have to be mod¬eled in order to understand the underlying mechanism of oscillations and to design new synthetic cellular clocks. This doctoral thesis has resulted in two contributions to the fields of genetic clocks and systems and synthetic biology, generally. The first contribution is a new genetic circuit model that exhibits an oscillatory behav¬ior through catalytic RNA molecules. The second and major contribution is a new genetic circuit model demonstrating that a repressor molecule acting on the positive feedback of a self-activating gene produces reliable oscillations. First contribution: A new model of a synthetic genetic oscillator based on a typical two-gene motif with one positive and one negative feedback loop is pre¬sented. The originality is that the repressor is a catalytic RNA molecule rather than a protein or a non-catalytic RNA molecule. This catalytic RNA is a ribozyme that acts post-transcriptionally by binding to and cleaving target mRNA molecules. This genetic clock involves just two genes, a mRNA and an activator protein, apart from the ribozyme. Parameter values that produce a circadian period in both determin¬istic and stochastic simulations have been chosen as an example of clock operation. The effects of the stochastic fluctuations are quantified by a period histogram and autocorrelation function. The conclusion is that catalytic RNA molecules can act as repressor proteins and simplify the design of genetic oscillators. Second and major contribution: It is demonstrated that a self-activating gene in conjunction with a simple negative interaction can easily produce robust matically validated. This model is comprised of two clearly distinct parts. The first is a positive feedback created by a protein that binds to the promoter of its own gene and activates the transcription. The second is a negative interaction in which a repressor molecule prevents this protein from binding to its promoter. A stochastic study shows that the system is robust to noise. A deterministic study identifies that the oscillator dynamics are mainly driven by two types of biomolecules: the protein, and the complex formed by the repressor and this protein. The main conclusion of this study is that a simple and usual negative interaction, such as degradation, se¬questration or inhibition, acting on the positive transcriptional feedback of a single gene is a sufficient condition to produce reliable oscillations. One gene is enough and the positive transcriptional feedback signal does not need to activate a second repressor gene. At the genetic level, this means that an explicit negative feedback loop is not necessary. Unlike many genetic oscillators, this model needs neither cooperative binding reactions nor the formation of protein multimers. Applications and future research directions: Recently, RNA molecules have been found to play many new catalytic roles. The first oscillatory genetic model proposed in this thesis uses ribozymes as repressor molecules. This could provide new synthetic biology design principles and a better understanding of cel¬lular clocks regulated by RNA molecules. The second genetic model proposed here involves only a repression acting on a self-activating gene and produces robust oscil¬lations. Unlike current two-gene oscillators, this model surprisingly does not require a second repressor gene. This result could help to clarify the design principles of cellular clocks and constitute a new efficient tool for engineering synthetic genetic oscillators. Possible follow-on research directions are: validate models in vivo and in vitro, research the potential of second model as a genetic memory, investigate new genetic oscillators regulated by non-coding RNAs and design a biosensor of positive feedbacks in genetic networks based on the operation of the second model Resumen Introduccion y motivacion: Una amplia variedad de organismos han desarro-llado relojes biomoleculares internos con el fin de adaptarse a los cambios ciclicos del entorno. El funcionamiento de estos relojes involucra redes geneticas. El mo delado de estas redes geneticas es esencial tanto para entender los mecanismos que producen las oscilaciones como para diseiiar nuevos circuitos sinteticos en celulas. Esta tesis doctoral ha dado lugar a dos contribuciones dentro de los campos de los circuitos geneticos en particular, y biologia de sistemas y sintetica en general. La primera contribucion es un nuevo modelo de circuito genetico que muestra un comportamiento oscilatorio usando moleculas de ARN cataliticas. La segunda y principal contribucion es un nuevo modelo de circuito genetico que demuestra que una molecula represora actuando sobre el lazo de un gen auto-activado produce oscilaciones robustas. Primera contribucion: Es un nuevo modelo de oscilador genetico sintetico basado en una tipica red genetica compuesta por dos genes con dos lazos de retroa-limentacion, uno positivo y otro negativo. La novedad de este modelo es que el represor es una molecula de ARN catalftica, en lugar de una protefna o una molecula de ARN no-catalitica. Este ARN catalitico es una ribozima que actua despues de la transcription genetica uniendose y cortando moleculas de ARN mensajero (ARNm). Este reloj genetico involucra solo dos genes, un ARNm y una proteina activadora, aparte de la ribozima. Como ejemplo de funcionamiento, se han escogido valores de los parametros que producen oscilaciones con periodo circadiano (24 horas) tanto en simulaciones deterministas como estocasticas. El efecto de las fluctuaciones es-tocasticas ha sido cuantificado mediante un histograma del periodo y la función de auto-correlacion. La conclusion es que las moleculas de ARN con propiedades cataliticas pueden jugar el misnio papel que las protemas represoras, y por lo tanto, simplificar el diseno de los osciladores geneticos. Segunda y principal contribucion: Es un nuevo modelo de oscilador genetico que demuestra que un gen auto-activado junto con una simple interaction negativa puede producir oscilaciones robustas. Este modelo ha sido estudiado y validado matematicamente. El modelo esta compuesto de dos partes bien diferenciadas. La primera parte es un lazo de retroalimentacion positiva creado por una proteina que se une al promotor de su propio gen activando la transcription. La segunda parte es una interaction negativa en la que una molecula represora evita la union de la proteina con el promotor. Un estudio estocastico muestra que el sistema es robusto al ruido. Un estudio determinista muestra que la dinamica del sistema es debida principalmente a dos tipos de biomoleculas: la proteina, y el complejo formado por el represor y esta proteina. La conclusion principal de este estudio es que una simple y usual interaction negativa, tal como una degradation, un secuestro o una inhibition, actuando sobre el lazo de retroalimentacion positiva de un solo gen es una condition suficiente para producir oscilaciones robustas. Un gen es suficiente y el lazo de retroalimentacion positiva no necesita activar a un segundo gen represor, tal y como ocurre en los relojes actuales con dos genes. Esto significa que a nivel genetico un lazo de retroalimentacion negativa no es necesario de forma explicita. Ademas, este modelo no necesita reacciones cooperativas ni la formation de multimeros proteicos, al contrario que en muchos osciladores geneticos. Aplicaciones y futuras lineas de investigacion: En los liltimos anos, se han descubierto muchas moleculas de ARN con capacidad catalitica. El primer modelo de oscilador genetico propuesto en esta tesis usa ribozimas como moleculas repre¬soras. Esto podria proporcionar nuevos principios de diseno en biologia sintetica y una mejor comprension de los relojes celulares regulados por moleculas de ARN. El segundo modelo de oscilador genetico propuesto aqui involucra solo una represion actuando sobre un gen auto-activado y produce oscilaciones robustas. Sorprendente-mente, un segundo gen represor no es necesario al contrario que en los bien conocidos osciladores con dos genes. Este resultado podria ayudar a clarificar los principios de diseno de los relojes celulares naturales y constituir una nueva y eficiente he-rramienta para crear osciladores geneticos sinteticos. Algunas de las futuras lineas de investigation abiertas tras esta tesis son: (1) la validation in vivo e in vitro de ambos modelos, (2) el estudio del potential del segundo modelo como circuito base para la construction de una memoria genetica, (3) el estudio de nuevos osciladores geneticos regulados por ARN no codificante y, por ultimo, (4) el rediseno del se¬gundo modelo de oscilador genetico para su uso como biosensor capaz de detectar genes auto-activados en redes geneticas.

Towards architectural foundations for cognitive self-aware systems

In this talk we address a proposal concerning a methodology for extracting universal, domain neutral, architectural design patterns from the analysis of biological cognition. This will render a set of design principles and design patterns oriented towards the construction of better machines. Bio- inspiration cannot be a one step process if we we are going to to build robust, dependable autonomous agents; we must build solid theories first, departing from natural systems, and supporting our designs of artificial ones.

Atmospheric modelling of tritium forms transport: review of capabilities and R&D needs for the assessment of fusion facilities environmental impact

One of the key scrutiny issues of new coming energy era would be the environmental impact of fusion facilities managing one kg of tritium. The potential change of committed dose regulatory limits together with the implementation of nuclear design principles (As Low as Reasonably achievable - ALARA -, Defense in Depth -D-i-D-) for fusion facilities could strongly impact on the cost of deployment of coming fusion technology. Accurate modeling of environmental tritium transport forms (HT, HTO) for the assessment of fusion facility dosimetric impact in Accidental case appears as of major interest. This paper considers different short-term releases of tritium forms (HT and HTO) to the atmosphere from a potential fusion reactor located in the Mediterranean Basin. This work models in detail the dispersion of tritium forms and dosimetric impact of selected environmental patterns both inland and in-sea using real topography and forecast meteorological data-fields (ECMWF/FLEXPART). We explore specific values of this ratio in different levels and we examine the influence of meteorological conditions in the HTO behavior for 24 hours. For this purpose we have used a tool which consists on a coupled Lagrangian ECMWF/FLEXPART model useful to follow real time releases of tritium at 10, 30 and 60 meters together with hourly observations of wind (and in some cases precipitations) to provide a short-range approximation of tritium cloud behavior. We have assessed inhalation doses. And also HTO/HT ratios in a representative set of cases during winter 2010 and spring 2011 for the 3 air levels.

Comportamiento estructural de elementos de fábrica reforzados con materiales compuestos avanzados solicitados a flexión y flexocompresión

El refuerzo de estructuras existentes mediante el encolado exterior de láminas de polímeros reforzados con fibras (FRP) se ha convertido en la aplicación más común de los materiales compuestos avanzados en construcción. Estos materiales presentan muchas ventajas frente a los materiales convencionales (sin corrosión, ligeros, de fácil aplicación, etc.). Pero a pesar de las numerosas investigaciones realizadas, aún persisten ciertas dudas sobre algunos aspectos de su comportamiento y las aplicaciones prácticas se llevan a cabo sólo con la ayuda de guías, sin que haya una normativa oficial. El objetivo de este trabajo es incrementar el conocimiento sobre esta técnica de refuerzo, y más concretamente, sobre el refuerzo a flexión de estructuras de fábrica. Con frecuencia el elemento reforzado es de hormigón armado y las láminas de FRP encoladas al exterior sirven para mejorar su resistencia a flexión, cortante o compresión (encamisados). Sin embargo su empleo en otros materiales como las estructuras de fábrica resulta muy prometedor. Las fábricas se caracterizan por soportar muy bien los esfuerzos de compresión pero bastante mal los de tracción. Adherir láminas de materiales compuestos puede servir para mejorar la capacidad resistente de elementos de fábrica sometidos a esfuerzos de flexión. Pero para ello, debe quedar garantizada una correcta adherencia entre el FRP y la fábrica, especialmente en edificios antiguos cuya superficie puede estar deteriorada por encontrarse a la intemperie o por el propio paso del tiempo. En el capítulo II se describen los objetivos fundamentales del trabajo y el método seguido. En el capítulo III se hace una amplia revisión del estado de conocimiento sobre el tema. En el apartado III.1 se detallan las principales características y propiedades mecánicas de fibras, matrices y materiales compuestos así como sus principales aplicaciones, haciendo especial hincapié en aspectos relativos a su durabilidad. En el apartado III.2 se incluye una revisión histórica de las líneas de investigación, tanto teóricas como empíricas, publicadas sobre estructuras de hormigón reforzadas a flexión encolando materiales compuestos. El apartado III.3 se centra en el aspecto fundamental de la adherencia refuerzo-soporte. Se hace un repaso a distintos modelos propuestos para prevenir el despegue distinguiendo si éste se inicia en la zona de anclaje o si está inducido por fisuras en la zona interior del elemento. Se observa falta de consenso en las propuestas. Además en este punto se relatan las campañas experimentales publicadas acerca de la adherencia entre materiales compuestos y fábricas. En el apartado III.4 se analizan las particularidades de las estructuras de fábrica. Además, se revisan algunas de las investigaciones relativas a la mejora de su comportamiento a flexión mediante láminas de FRP. El comportamiento mecánico de muros reforzados solicitados a flexión pura (sin compresión) ha sido documentado por varios autores, si bien es una situación poco frecuente en fábricas reales. Ni el comportamiento mecánico de muros reforzados solicitados a flexocompresión ni la incidencia que el nivel de compresión soportado por la fábrica tiene sobre la capacidad resistente del elemento reforzado han sido suficientemente tratados. En cuanto a los trabajos teóricos, las diferentes propuestas se basan en los métodos utilizados para hormigón armado y comparten los principios habituales de cálculo. Sin embargo, presentan diferencias relativas, sobre todo, a tres aspectos: 1) la forma de modelar el comportamiento de la fábrica, 2) el valor de deformación de cálculo del refuerzo, y 3) el modo de fallo que se considera recomendable buscar con el diseño. A pesar de ello, el ajuste con la parte experimental de cada trabajo suele ser bueno debido a una enorme disparidad en las variables consideradas. Cada campaña presenta un modo de fallo característico y la formulación que se propone resulta apropiada para él. Parece necesario desarrollar un método de cálculo para fábricas flexocomprimidas reforzadas con FRP que pueda ser utilizado para todos los posibles fallos, tanto atribuibles a la lámina como a la fábrica. En el apartado III.4 se repasan algunas lesiones habituales en fábricas solicitadas a flexión y se recogen ejemplos de refuerzos con FRP para reparar o prevenir estos daños. Para mejorar el conocimiento sobre el tema, se llevan a cabo dos pequeñas campañas experimentales realizadas en el Instituto de Ciencias de la Construcción Eduardo Torroja. La primera acerca de la adherencia de materiales compuestos encolados a fábricas deterioradas (apartado IV.1) y la segunda sobre el comportamiento estructural a flexocompresión de probetas de fábrica reforzadas con estos materiales (apartado IV.2). En el capítulo V se analizan algunos de los modelos de adherencia propuestos para prevenir el despegue del extremo del refuerzo. Se confirma que las predicciones obtenidas con ellos resultan muy dispares. Se recopila una base de datos con los resultados experimentales de campañas sobre adherencia de FRP a fábricas extraídas de la literatura y de los resultados propios de la campaña descrita en el punto IV.1. Esta base de datos permite conocer cual de los métodos analizados resulta más adecuado para dimensionar el anclaje de láminas de FRP adheridas a fábricas. En el capítulo VI se propone un método para la comprobación en agotamiento de secciones de fábrica reforzadas con materiales compuestos sometidas a esfuerzos combinados de flexión y compresión. Está basado en el procedimiento de cálculo de la capacidad resistente de secciones de hormigón armado pero adaptado a las fábricas reforzadas. Para ello, se utiliza un diagrama de cálculo tensión deformación de la fábrica de tipo bilineal (acorde con el CTE DB SE-F) cuya simplicidad facilita el desarrollo de toda la formulación al tiempo que resulta adecuado para predecir la capacidad resistente a flexión tanto para fallos debidos al refuerzo como a la fábrica. Además se limita la deformación de cálculo del refuerzo teniendo en consideración ciertos aspectos que provocan que la lámina adherida no pueda desarrollar toda su resistencia, como el desprendimiento inducido por fisuras en el interior del elemento o el deterioro medioambiental. En concreto, se propone un “coeficiente reductor por adherencia” que se determina a partir de una base de datos con 68 resultados experimentales procedentes de publicaciones de varios autores y de los ensayos propios de la campaña descrita en el punto IV.2. También se revisa la formulación propuesta con ayuda de la base de datos. En el capítulo VII se estudia la incidencia de las principales variables, como el axil, la deformación de cálculo del refuerzo o su rigidez, en la capacidad final del elemento. Las conclusiones del trabajo realizado y las posibles líneas futuras de investigación se exponen en el capítulo VIII. ABSTRACT Strengthening of existing structures with externally bonded fiber reinforced polymers (FRP) has become the most common application of advanced composite materials in construction. These materials exhibit many advantages in comparison with traditional ones (corrosion resistance, light weight, easy to apply, etc.). But despite countless researches have been done, there are still doubts about some aspects of their behaviour and applications are carried out only with the help of guidelines, without official regulations. The aim of this work is to improve the knowledge on this retrofitting technique, particularly in regard to flexural strengthening of masonry structures. Reinforced concrete is often the strengthened material and external glued FRP plates are used to improve its flexural, shear or compressive (by wrapping) capacity. However the use of this technique on other materials like masonry structures looks promising. Unreinforced masonry is characterized for being a good material to support compressive stresses but really bad to withstand tensile ones. Glue composite plates can improve the flexural capacity of masonry elements subject to bending. But a proper bond between FRP sheet and masonry must be ensured to do that, especially in old buildings whose surface can be damaged due to being outside or ageing. The main objectives of the work and the methodology carried out are described In Chapter II. An extensive overview of the state of art is done in Chapter III. In Section III.1 physical and mechanical properties of fibers, matrix and composites and their main applications are related. Durability aspects are especially emphasized. Section III.2 includes an historical overview of theoretical and empirical researches on concrete structures strengthened gluing FRP plates to improve their flexural behaviour. Section III.3 focuses on the critical point of bonding between FRP and substrate. Some theoretical models to prevent debonding of FRP laminate are reviewed, it has made a distinction between models for detachment at the end of the plate or debonding in the intermediate zones due to the effects of cracks. It is observed a lack of agreement in the proposals. Some experimental studies on bonding between masonry and FRP are also related in this chapter. The particular characteristics of masonry structures are analyzed in Section III.4. Besides some empirical and theoretical investigations relative to improve their flexural capacity with FRP sheets are reviewed. The mechanical behaviour of strengthened walls subject to pure bending (without compression) has been established by several authors, but this is an unusual situation for real masonry. Neither mechanical behaviour of walls subject to bending and compression nor influence of axial load in the final capacity of the strengthened element are adequately studied. In regard to theoretical studies, the different proposals are based on reinforced concrete analytical methods and share common design principles. However, they present differences, especially, about three aspects: 1) the constitutive law of masonry, 2) the value of ultimate FRP strain and 3) the desirable failure mode that must be looked for. In spite of them, a good agreement between each experimental program and its theoretical study is often exhibited due to enormous disparity in considered test parameters. Each experimental program usually presents a characteristic failure mode and the proposed formulation results appropriate for this one. It seems necessary to develop a method for FRP strengthened walls subject to bending and compression enable for all failure modes (due to FRP or masonry). Some common damages in masonry subject to bending are explained in Section III.4. Examples of FRP strengthening to repair or prevent these damages are also written. Two small experimental programs are carried out in Eduardo Torroja Institute to improve the knowledge on this topic. The first one is concerned about the bond between FRP plates and damaged masonry (section IV.1) and the second one is related to the mechanical behaviour of the strengthened masonry specimens subject to out of plane bending combined with axial force (section IV.2). In the Chapter V some bond models to prevent the debonding at the FRP plate end are checked. It is confirmed that their predictions are so different. A pure-shear test database is compiled with results from the existing literature and others from the experimental program described in section IV.1. This database lets know which of the considered model is more suitable to design anchorage lengths of glued FRP to masonry. In the Chapter VI a method to check unreinforced masonry sections with external FRP strengthening subject to bending and compression to the ultimate limit state is proposed. This method is based on concrete reinforced one, but it is adapted to strengthened masonry. A bilinear constitutive law is used for masonry (according to CTE DB SE-F). Its simplicity helps to develop the model formulation and it has proven to be suitable to predict bending capacity either for FRP failures or masonry crushing. With regard to FRP, the design strain is limited. It is taken into account different aspects which cause the plate can’t reach its ultimate strength, like intermediate FRP debonding induced by opening cracking or environmental damage. A “bond factor” is proposed. It is obtained by means of an experimental bending test database that includes 68 results from the existing literature and from the experimental program described in section IV.2. The proposed formulation has also been checked with the help of bending database. The effects of the main parameters, like axial load, FRP design effective strain or FRP stiffness, on the bending capacity of the strengthened element are studied in Chapter VII. Finally, the main conclusions from the work carried out are summarized in Chapter VIII. Future lines of research to be explored are suggested as well.

Creating and modelling personal socio-economic networks in on-line banking

The banking industry is observing how new competitors threaten its millennial business model by targeting unbanked people, offering new financial services to their customer base, and even enabling new channels for existing services and customers. The knowledge on users, their behaviour, and expectations become a key asset in this new context. Well aware of this situation, the Center for Open Middleware, a joint technology center created by Santander Bank and Universidad Politécnica de Madrid, has launched a set of initiatives to allow the experimental analysis and management of socio-economic information. PosdataP2P service is one of them, which seeks to model the economic ties between the holders of university smart cards, leveraging on the social networks the holders are subscribed to. In this paper we describe the design principles guiding the development of the system, its architecture and some implementation details.

Seven challenges for RESTful transaction models

The REpresentational State Transfer (REST) architectural style describes the design principles that made the World Wide Web scalable and the same principles can be applied in enterprise context to do loosely coupled and scalable application integration. In recent years, RESTful services are gaining traction in the industry and are commonly used as a simpler alternative to SOAP Web Services. However, one of the main drawbacks of RESTful services is the lack of standard mechanisms to support advanced quality-ofservice requirements that are common to enterprises. Transaction processing is one of the essential features of enterprise information systems and several transaction models have been proposed in the past years to fulfill the gap of transaction processing in RESTful services. The goal of this paper is to analyze the state-of-the-art RESTful transaction models and identify the current challenges.

Desarrollo de ontología de títulos de grado

Dada la amplia información que rodea el dominio de programas de estudios superiores, específicamente los estudios de grado, este trabajo fin de grado propone la construcción de un modelo para representar dicha información mediante la construcción de una red de ontologías, proporcionando una definición común de conceptos importantes, y que posteriormente puede ser reutilizada para la construcción de aplicaciones que ayuden a las partes interesadas, como, estudiantes, personal académico y administrativo, a la búsqueda y acceso de información oportuna. Para la construcción de esta red de ontologías, se siguen las recomendaciones y pautas propuestas por la metodología NeOn [1a] [1b], que sigue un paradigma basado en la reutilización de recursos de conocimiento. Por otra parte, se realiza una populación de dicha red de ontologías mediante datos específicos del grado en Ingeniería Informática de la Universidad Politécnica de Madrid. La construcción de una red de ontologías siguiendo las directrices de la metodología NeOn requiere la realización de distintas actividades y tareas, como el estudio del dominio, estudio de la viabilidad, especificación de requisitos, conceptualización, formalización, implementación y mantenimiento. Se realizan también muchas otras actividades y tareas dependiendo del contexto en el que se construye la ontología. En este proyecto se hace un especial énfasis en las actividades de especificación de requisitos, conceptualización e implementación, además de la actividad de búsqueda de recursos ontológicos para su posterior reutilización. Se ha construido una red de ontologías llamada: European Bachelor Degree Ontology (EBDO) que incluye términos y conceptos importantes que se han detectado en la etapa de especificación de requisitos y que las ontologías a reutilizar no contemplan. Las decisiones de diseño para la construcción de esta nueva red de ontologías y su alineamiento con las ontologías a reutilizar se han basado en la especificación de requisitos ontológicos. Una vez definidos los conceptos relevantes de la red de ontologías, se ha implementado la red de ontologías en un lenguaje computable. Una vez que la red de ontologías se ha implementado se han realizado tareas de evaluación para corregir posible errores. Finalmente, cuando se ha obtenido una versión estable de la ontología, se ha realizado la instanciación de individuos del plan de estudios del grado en Ingeniería Informática de la Universidad Politécnica de Madrid.---ABSTRACT---Given the extensive information surrounding the domain of higher education programs, specifically bachelor degree studies, this bachelor degree project proposes the construction of a model to represent this information by building an ontology network, providing a common definition of important concepts. This network can be reused to build semantic applications that help stakeholders, such as, students, academic and organisational staff, to search and access to timely information. For the construction of this network of ontologies, guidelines and recommendations proposed by the NeOn Methodology [1a] [1b] have been followed. This methodology follows a paradigm based on the reuse of knowledge resources. Moreover, a population of this ontology network is performed with specific data of the Computer Science Degree from Universidad Politécnica de Madrid Building a network of ontologies following the guidelines of the NeOn Methodology requires the completion of various activities and tasks such as, the study of the domain, study of the feasibility, requirements specification, conceptualization, formalization, implementation and maintenance. Many other activities and tasks are also performed depending on the context in which the ontology is built. In this project a special emphasis is made on the activities of requirements specification, conceptualization and search of ontological resources for reuse and implementation. A new network of ontologies, named European Bachelor Degree Ontology (EBDO), has been built. This network includes terms and concepts that have been detected at the stage of requirements specification and that the reused ontologies have not contemplated. Design principles for the construction of this new network of ontologies and for the reused ontologies alignment have been based on the ontological specification requirements. Once the relevant concepts of the ontology network are defined, the network has been implemented in a computable ontology language. Once the network ontology is implemented, the evaluation activity has been conducted to correct the errors that the network presented. Finally, when a stable version of the ontology has been obtained, the instantiation of individuals of the study program of the Bachelor Degree in Computer Science from Universidad Politécnica de Madrid has been performed.

On the biomimetic design of agile-robot legs

The development of functional legged robots has encountered its limits in human-made actuation technology. This paper describes research on the biomimetic design of legs for agile quadrupeds. A biomimetic leg concept that extracts key principles from horse legs which are responsible for the agile and powerful locomotion of these animals is presented. The proposed biomimetic leg model defines the effective leg length, leg kinematics, limb mass distribution, actuator power, and elastic energy recovery as determinants of agile locomotion, and values for these five key elements are given. The transfer of the extracted principles to technological instantiations is analyzed in detail, considering the availability of current materials, structures and actuators. A real leg prototype has been developed following the biomimetic leg concept proposed. The actuation system is based on the hybrid use of series elasticity and magneto-rheological dampers which provides variable compliance for natural motion. From the experimental evaluation of this prototype, conclusions on the current technological barriers to achieve real functional legged robots to walk dynamically in agile locomotion are presented.

Some methodological issues in the design of CIAO - A generic, parallel concurrent constraint system

We informally discuss several issues related to the parallel execution of logic programming systems and concurrent logic programming systems, and their generalization to constraint programming. We propose a new view of these systems, based on a particular definition of parallelism. We argüe that, under this view, a large number of the actual systems and models can be explained through the application, at different levéis of granularity, of only a few basic principies: determinism, non-failure, independence (also referred to as stability), granularity, etc. Also, and based on the convergence of concepts that this view brings, we sketch a model for the implementation of several parallel constraint logic programming source languages and models based on a common, generic abstract machine and an intermedíate kernel language.

Technological development in Spanish gothic vaults design

The principle of complexity as the evolution vector of the gothic style was an idea largely developed by Paul Frankl. The high complexity reached in the 15th and 16th centuries was possible thanks to the geometrical resources developed in the workshops of the medieval stonemasons. The search for more sophisticated designs was possible also with the higher standardization, so that the most complex ribbed vault could be built with ribs that had all the same curvature and with voussoirs that were therefore identical. Spanish Gothic architecture has been deeply studied from a historical and artistic point of view. The present paper, as a complement to these analyses, aims to point out some of the geometrical methods and technological improvements that late medieval masons were able to develop. In that way, some selected vaults have been measured, in order to study their geometry and design process. Also scale models of some vaults have been built at the Escuela de Arquitectura (Madrid) to validate these geometrical principles. More than just a research method, the scale models allow to understand the medieval construction techniques, and they are a powerful pedagogical tool with which pupils can reach a rewarding experience based on the “medieval-way” praxis.

Supporting the design and development of Project Based Learning courses.

The use of Project Based Learning has spread widely over the last decades, not only throughout countries but also among disciplines. One of the most significant characteristics of this methodology is the use of ill-structured problems as central activity during the course, which represents an important difficulty for both teachers and students. This work presents a model, supported by a tool, focused on helping teachers and students in Project Based Learning, overcoming these difficulties. Firstly, teachers are guided in designing the project following the main principles of this methodology. Once the project has been specified at the desired level of depth, the same tool helps students to finish the project specification and organize the implementation. Collaborative work among different users is allowed in both phases. This tool has been satisfactorily tested designing two real projects used in Computer Engineering and Software Engineering degrees.