6 resultados para ANTIOXIDANT SYSTEM

em Universidade dos Açores - Portugal


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Copyright © 2013 Springer Netherlands.

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3rd Portuguese Meeting on Medicinal Chemistry and 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, Aveiro, 28-30 Novembro 2012.

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6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, Lisboa, de 18 a 20 de Julho de 2012 (Poster Communication).

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Natural and synthetic xanthone derivatives are well-known for their ability to act as antioxidants and/or enzyme inhibitors. This paper aims to present a successful synthetic methodology towards xanthenedione derivatives and the study of their aromatization to xanthones. Additionally their ability to reduce Fe(III), to scavenge DPPH radicals and to inhibit AChE was evaluated. The results demonstrated that xanthenedione derivative 5e, bearing a catechol unit, showed higher reduction capacity than BHT and similar to quercetin, strong DPPH scavenging activity (EC50 = 3.79 ± 0.06 μM) and it was also showed to be a potent AChEI (IC50 = 31.0 ± 0.09 μM) when compared to galantamine (IC50 = 211.8 ± 9.5 μM).

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On this work we suggest a teaching solution that can be implemented in Azores, an archipelago of nine islands of Portugal, based in already known system of e-learning, with a twist based on the flipped method. Structured in a cooperative way, the organization of the system allows to isolated groups of people to have access to a certain level of teaching, if they cannot have the possibility to have physical presence in school due to problems emerging from territory discontinuity. Our suggestion can be elaborate in a model that can be adapted to any level of education, and can be adapted also in cases that a cut of budget exists. We suggest the name of fb-learning: Flipped Broadcast Learning.

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Dissertação de Mestrado, Tecnologia e Segurança Alimentar, 14 de Dezembro de 2015, Universidade dos Açores.