Synthesis and antioxidant activity of new xanthone-type compounds

3rd Portuguese Meeting on Medicinal Chemistry and 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, Aveiro, 28-30 Novembro 2012.

Owing to our continuing interest in the synthesis of novel oxygen heterocycles we have recently developed a unique synthetic procedure towards the synthesis of new xanthenodiones (2)[5] and extend the work to their aromatization into xanthones (3). Our aim was also to obtain new derivatives with potential biological activities, therefore their ability to scavenge the DPPH radical and to reduce iron(III) were also evaluated. In the present communication we will present and discussed our last results on the synthetic and potential application of xanthones (3).

Thanks are due to the University of Aveiro, Fundação para a Ciência e a Tecnologia (FCT) and FEDER for funding the Organic Chemistry Research Unit (project PEst-C/QUI/UI0062/2011). We are also grateful to the Portuguese National NMR Network (RNRMN) supported with funds from FCT.