Indium-Mediated Cleavage of the Trityl Group from Protected 1H-Tetrazoles
| Contribuinte(s) |
Universidad de Alicante. Departamento de Química Orgánica Universidad de Alicante. Instituto Universitario de Síntesis Orgánica Catálisis Estereoselectiva en Síntesis Orgánica (CESO) Síntesis Asimétrica (SINTAS) |
|---|---|
| Data(s) |
22/09/2016
22/09/2016
19/06/2015
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| Resumo |
On treatment with indium metal in MeOH–THF, trityl groups undergo reductive removal from 1H-protected tetrazoles (including aliphatic, aromatic, and heteroaromatic substituents), affording the corresponding free tetrazoles in excellent yields, without any decomposition of the tetrazole ring or reduction of any other group. This work was financially supported by the A.N.D.R.S (Agence Nationale pour le Développement de la Recherche en Santé) (Algérie), the Ministerio de Ciencia e Innovación of Spain (CTQ2011-24165, Consolider Ingenio 2010 CSD2007-00006), The Generalitat Valenciana (PROMETEO/2009/039, PROMETEOII/ 2014/017 and FEDER). We are very grateful to the Spanish Ministerio de Asuntos Exteriores y de Cooperación for a cooperation grant (AP/039112/11). |
| Identificador |
Synlett. 2015, 26(17): 2399-2402. doi:10.1055/s-0034-1379933 0936-5214 (Print) 1437-2096 (Online) http://hdl.handle.net/10045/58133 10.1055/s-0034-1379933 |
| Idioma(s) |
eng |
| Publicador |
Georg Thieme Verlag |
| Relação |
http://dx.doi.org/10.1055/s-0034-1379933 |
| Direitos |
© Georg Thieme Verlag Stuttgart · New York info:eu-repo/semantics/openAccess |
| Palavras-Chave | #Tetrazole #Indium #Detritylation #Cleavage #Química Orgánica |
| Tipo |
info:eu-repo/semantics/article |
