Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation
| Data(s) |
10/09/2015
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|---|---|
| Resumo |
<p>Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid- and solution-state. This class of molecule may be suitable for the mediation of therapeutically relevant protein-protein interactions. </p> |
| Identificador |
http://dx.doi.org/10.1002/chem.201502690 http://www.scopus.com/inward/record.url?scp=84973426964&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/closedAccess |
| Fonte |
Ross , J E , Knipe , P C , Thompson , S & Hamilton , A D 2015 , ' Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation ' Chemistry - A European Journal , vol 21 , no. 39 , pp. 13518-13521 . DOI: 10.1002/chem.201502690 |
| Palavras-Chave | #foldamer #peptidomimetics #protein surface #protein-protein interaction #secondary structure #β-sheet #/dk/atira/pure/subjectarea/asjc/2700 #Medicine(all) |
| Tipo |
article |
