Physical linkage to drug resistance genes results in conservation of var genes among west pacific Plasmodium falciparum isolates


Autoria(s): Fowler, EV; Chavchich, M; Chen, NH; Peters, JM; Kyle, DE; Gatton, ML; Cheng, Q
Data(s)

01/10/2006

Resumo

The multicopy var gene family encoding the variant surface antigen Plasmodium falciparum erythrocyte membrane protein 1 is highly diverse, with little overlap between different P. falciparum isolates. We report 5 var genes (varS1-varS5) that are shared at relatively high frequency among 63 genetically diverse P. falciparum isolates collected from 5 islands in the West Pacific region. The varS1, varS2, and varS3 genes were localized to the internal region on chromosome 4, similar to 200 kb from pfdhfr-ts, whereas varS4 and varS5 were mapped to an internal region of chromosome 7, within 100 kb of pfcrt. The presence of varS2 and varS3 were significantly correlated with the pyrimethamine-resistant pfdhfr genotype, whereas varS4 was strongly correlated with the chloroquine-resistant pfcrt genotype. Thus, the conservation of these var genes is the result of their physical linkage with drug-resistant genes in combination with the antimalarial drug pressure in the region.

Identificador

http://espace.library.uq.edu.au/view/UQ:80570

Idioma(s)

eng

Publicador

University Chicago Press

Palavras-Chave #Infectious Diseases #Chloroquine Resistance #Malaria Parasites #Infected Erythrocytes #Chondroitin Sulfate #Adhesive Domains #Binding Domain #East-timor #Identification #Pfcrt #Diversity #CX
Tipo

Journal Article