Benign intracranial hypertension associated with acromegaly
Contribuinte(s) |
Dr D Lynn Loriaux |
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Data(s) |
01/01/2005
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Resumo |
This is the first reported case of benign intracranial hypertension (BIH) occurring with acromegaly and resolving after successful treatment of a growth hormone-secreting pituitary adenoma. BIH has been reported with recombinant human growth hormone (rhGH) therapy of GH deficient patients and insulin-like growth factor I (IGF-I) treatment of growth hormone (GH) insensitivity (Laron syndrome) in children. We postulate that the proposed mechanism causing BIH in rhGH-treated children and in acromegaly results from increased cerebrospinal fluid production from the choroid plexi secondary to elevated cerebrospinal fluid growth hormone concentrations that trigger local IGF-I secretion and activation of IGF-I receptors. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Lippincott Williams & Wilkins |
Palavras-Chave | #Endocrinology & Metabolism #Acromegaly #Benign Intracranial Hypertension #Pseudotumor Cerebri #Growth Hormone #Igf I #Human Growth-hormone #Factor-i #Children #Brain #CX #321004 Endocrinology #730105 Endocrine organs and diseases (incl. diabetes) |
Tipo |
Journal Article |