Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.


Autoria(s): Hergenroeder, Georgene W; Moore, Anthony N; McCoy, J Philip; Samsel, Leigh; Ward, Norman H; Clifton, Guy L; Dash, Pramod K
Data(s)

01/01/2010

Resumo

BACKGROUND: Increased intracranial pressure (ICP) is a serious, life-threatening, secondary event following traumatic brain injury (TBI). In many cases, ICP rises in a delayed fashion, reaching a maximal level 48-96 hours after the initial insult. While pressure catheters can be implanted to monitor ICP, there is no clinically proven method for determining a patient's risk for developing this pathology. METHODS: In the present study, we employed antibody array and Luminex-based screening methods to interrogate the levels of inflammatory cytokines in the serum of healthy volunteers and in severe TBI patients (GCS RESULTS: Consistent with previous reports, we observed sustained increases in IL-6 levels in TBI patients irrespective of their ICP status. However, the group of patients who subsequently experienced ICP >or= 25 mm Hg had significantly higher IL-6 levels within the first 17 hours of injury as compared to the patients whose ICP remained 128 pg/ml correctly identified 85% of isolated TBI patients who subsequently developed elevated ICP, and values between these cut-off values correctly identified 75% of all patients whose ICP remained CONCLUSIONS: Our results suggest that serum IL-6 can be used for the differential diagnosis of elevated ICP in isolated TBI.

Identificador

http://digitalcommons.library.tmc.edu/uthmed_docs/28

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853529/?tool=pmcentrez

Publicador

DigitalCommons@The Texas Medical Center

Fonte

UT Medical School Journal Articles

Palavras-Chave #APACHE #Adolescent #Adult #Aged #Biological Markers #Brain Injuries #Cytokines #Enzyme-Linked Immunosorbent Assay #Female #Fractures #Bone #Glasgow Coma Scale #Humans #Injury Severity Score #Interleukin-6 #Intracranial Hypertension #Male #Middle Aged #Multiple Trauma #Predictive Value of Tests #Prognosis #Reagent Kits #Diagnostic #Recruitment #Neurophysiological #Reproducibility of Results #Tomography #X-Ray Computed #Young Adult #Fractures, Bone #Reagent Kits, Diagnostic #Recruitment, Neurophysiological #Tomography, X-Ray Computed #Medicine and Health Sciences
Tipo

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