Genomic mosaicism in two strains of Dengue virus type 3
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
18/03/2014
18/03/2014
01/08/2013
|
| Resumo |
Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses. FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo - 2010/19059-7) CNPq-PQ FAPESP - 2011/14537-0 FAPESP - 2011/17071-2 |
| Identificador |
Infection, Genetics and Evolution, Amsterdam, v.18, p.202-2012, 2013 http://www.producao.usp.br/handle/BDPI/44184 10.1016/j.meegid.2013.05.012 |
| Idioma(s) |
eng |
| Publicador |
Elsevier Science Amsterdam |
| Relação |
Infection, Genetics and Evolution |
| Direitos |
restrictedAccess Elsevier B.V. |
| Palavras-Chave | #Dengue virus type 3 #Phylogeny #Recombination #Split decomposition #Dengue #Filogenia #Diversidade genética #Recombinação genética |
| Tipo |
article original article publishedVersion |
