Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models


Autoria(s): Santos, Jandson S.; Marinho, Renata R.; Ekundi-Valentim, Eduardo; Rodrigues, Leandro; Yamamoto, Marcelo H.; Teixeira, Simone Aparecida; Muscara, Marcelo Nicolas; Costa, Soraia Kátia Pereira; Thomazzi, Sara M.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

24/01/2014

24/01/2014

21/06/2013

Resumo

Ethnopharmacological relevance:Anadenantheracolubrina (Vell.) Brenan,popularlyknownas “angico”, is a plantthathasbeenwidelyusedinfolkmedicineduetoitsanti-inflammatory property.Toevaluatethe pharmacological activitiesofthisplant,studieswereperformedonitsantinociceptiveandanti- inflammatoryproperties. Materials andmethods: The AEof Anadenantheracolubrina, madefromthebark,wasusedinrodentsvia oral route(p.o.),at100,200,and400mg/kginclassicalmodelsofnociception(aceticacid-induced writhing andhot-platetest)andinflammation evokedbycarrageenan(e.g.,pawedema,peritonitis,and synovitis). Results: The aceticacid-inducedabdominalwrithesinmiceweresignificantly reduced(Po0.001)by oral treatmentwiththeextract(100,200,and400mg/kg),buttheextractdidnotsignificantly increase the latencyinthenociceptivehot-platetest. Anadenantheracolubrina aqueousextractreduced significantly theedemaand,besides,diminishedthemieloperoxidaseactivity(200and400mg/kg, Po0.01).Thecarrageenan-inducedperitonitiswassignificantly reduced(Po0.05) bytheaqueous extractat100,200,and400mg/kg.Theaqueousextract(200mg/kg)reducesthesynovialleukocyte infiltration oncarrageenan-inducedsynovitisinrats(Po0.01),butfailedtosignificantly affectjoint swelling andimpairedmobility. Conclusions: Weshowforthe first timethattheanti-inflammatory andperipheralantinociceptive activities of Anadenantheracolubrina are consistent,atleastinpart,withtheuseofthisplantinpopular medicine practices.

Programa de Cooperação Acadêmica/ Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PROCAD/NF 2007-CAPES)

Identificador

Journal of Ethnopharmacology, Limerick, v.148, n.1, p.218-222, 2013

http://www.producao.usp.br/handle/BDPI/43862

10.1016/j.jep.2013.04.012

http://dx.doi.org/10.1016/j.jep.2013.04.012

Idioma(s)

eng

Publicador

Elsevier Sequoia

Limerick

Relação

Journal of Ethnopharmacology

Direitos

restrictedAccess

Elsevier Ireland Ltd

Palavras-Chave #Anadenantheracolubrina #Anti-inflammatory #Antinociceptive #Leukocyte influx #Edema #Synovitis #Antiinflamatórios #Leucócitos #Modelos animais #Ratos #Sinovite animal
Tipo

article

original article

publishedVersion