1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
06/11/2013
06/11/2013
2012
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| Resumo |
Twenty-three naphthoimidazoles and six naphthoxazoles were synthesised and evaluated against susceptible and rifampicin- and isoniazid-resistant strains of Mycobacterium tuberculosis. Among all the compounds evaluated, fourteen presented MIC values in the range of 0.78 to 6.25 mu g/mL against susceptible and resistant strains of M. tuberculosis, Five structures were solved by X-ray crystallographic analysis. These substances are promising antimycobacterial prototypes. (C) 2012 Elsevier Ltd. All rights reserved. National Research Council of Brazil (CNPq) CNPq (National Council of Research of Brazil) CAPES CAPES UFAL UFAL UFRJ UFRJ FURG FURG UFMG UFMG Programa Institucional de Auxilio a Pesquisa de Doutores Recem-Contratados-UFMG [08/2010] Programa Institucional de Auxilio a Pesquisa de Doutores RecemContratadosUFMG Universidade Federal de Minas Gerais Universidade Federal de Minas Gerais [PRPq-12/2011] FAPEMIG [APQ-04166-10] FAPEMIG |
| Identificador |
BIOORGANIC & MEDICINAL CHEMISTRY, OXFORD, v. 20, n. 21, supl. 1, Part 6, pp. 6482-6488, 37196, 2012 0968-0896 http://www.producao.usp.br/handle/BDPI/42452 10.1016/j.bmc.2012.08.041 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD OXFORD |
| Relação |
BIOORGANIC & MEDICINAL CHEMISTRY |
| Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #IMIDAZOLES #OXAZOLES #BETA-LAPACHONE #MYCOBACTERIUM TUBERCULOSIS #NOR-BETA-LAPACHONE #BIOLOGICAL EVALUATION #TRYPANOCIDAL ACTIVITY #TRYPANOSOMA-CRUZI #HETEROCYCLIC-DERIVATIVES #ANTITUBERCULAR AGENTS #NATURAL-PRODUCTS #RESISTANCE #INHIBITORS #QUINONES #BIOCHEMISTRY & MOLECULAR BIOLOGY #CHEMISTRY, MEDICINAL #CHEMISTRY, ORGANIC |
| Tipo |
article original article publishedVersion |
