Hyperinsulinemic hypoglycemia of the infancy. Analysis of clinical data from a Brazilian sample
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/09/2013
20/09/2013
01/12/2012
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Resumo |
Objective: To review the presentation of hyperinsulinemic hypoglycemia of the infancy (HHI), its treatment and histology in Brazilian pediatric endocrinology sections. Materials and method: The protocol analyzed data of birth, laboratory results, treatment, surgery, and pancreas histology. Results: Twenty-five cases of HHI from six centers were analyzed: 15 male, 3/25 born by vaginal delivery. The average age at diagnosis was 10.3 days. Glucose and insulin levels in the critical sample showed an average of 24.7 mg/dL and 26.3 UI/dL. Intravenous infusion of the glucose was greater than 10 mg/kg/min in all cases (M:19,1). Diazoxide was used in 15/25 of the cases, octreotide in 10, glucocorticoid in 8, growth hormone in 3, nifedipine in 2 and glucagon in 1. Ten of the cases underwent pancreatectomy and histology results showed the diffuse form of disease. Conclusion: This is the first critic review of a Brazilian sample with congenital HHI. Arq Bras Endocrinol Metab. 2012; 56(9): 666-71 |
Identificador |
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, RIO DE JANEIRO, RJ, v. 56, pp. 666-671, DEC, 2012 0004-2730 http://www.producao.usp.br/handle/BDPI/33549 10.1590/S0004-27302012000900011 |
Idioma(s) |
por |
Publicador |
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA RIO DE JANEIRO, RJ |
Relação |
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA |
Direitos |
openAccess Copyright SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA |
Palavras-Chave | #HYPOGLYCEMIA #CONGENITAL #HYPERINSULINEMIC HYPOGLYCEMIA OF THE INFANCY #HYPERINSULINISM #NESIDIOBLASTOSIS #CONGENITAL HYPERINSULINISM #HETEROGENEITY #MUTATIONS #DIAGNOSIS #MANAGEMENT #KCNJ11 #ABCC8 #ENDOCRINOLOGY & METABOLISM |
Tipo |
article original article publishedVersion |