Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
01/11/2013
01/11/2013
02/08/2013
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Resumo |
As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4), and 8'-multijuguinol (5), were isolated from the leaves of Senna multijuga (syn. Cassia multijuga). Their structures were elucidated on the basis of spectroscopic data analysis. Mass spectrometry was used for confirmation of the positions of the hydroxy groups in the side-chains of 1, 2, 4, and 5. All compounds exhibited weak in vitro acetylcholinesterase inhibitory activity as compared with the standard compound physostigmine. FAPESP, Biota-FAPESP FAPESP, BiotaFAPESP The Biodiversity Virtual Institute The Biodiversity Virtual Institute [03/02176-7] FAPESP FAPESP CAPES CAPES CNPq CNPq |
Identificador |
JOURNAL OF NATURAL PRODUCTS, WASHINGTON, v. 75, n. 3, supl. 1, Part 3, pp. 408-413, MAR, 2012 0163-3864 http://www.producao.usp.br/handle/BDPI/37170 10.1021/np200814j |
Idioma(s) |
eng |
Publicador |
AMER CHEMICAL SOC WASHINGTON |
Relação |
JOURNAL OF NATURAL PRODUCTS |
Direitos |
closedAccess Copyright AMER CHEMICAL SOC |
Palavras-Chave | #PIPERIDINE ALKALOIDS #CASSIA-SPECTABILIS #ANTINOCICEPTIVE PROFILE #ABSOLUTE-CONFIGURATION #GREEN FRUITS #(-)-SPECTALINE #CONSTITUENTS #LEPTOPHYLLA #ASSIGNMENT #SEEDS #PLANT SCIENCES #CHEMISTRY, MEDICINAL #PHARMACOLOGY & PHARMACY |
Tipo |
article original article publishedVersion |