Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
18/03/2015
18/03/2015
01/11/2014
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Resumo |
This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with beta-(beta CD), methyl-(M beta CD) and hydroxypropyl-P-cyclodextrin (HP beta CD) using meglumine (MEG) as the ternary component. The combination of MEG with M beta CD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and M beta CD or HP beta CD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and M beta CD or HP beta CD in the ternary lyophilized systems. The ternary complexes with beta CD and M beta CD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation. (C) 2014 Elsevier B.V. All rights reserved. |
Formato |
64-73 |
Identificador |
http://dx.doi.org/10.1016/j.jpba.2014.07.008 Journal Of Pharmaceutical And Biomedical Analysis. Amsterdam: Elsevier Science Bv, v. 100, p. 64-73, 2014. 0731-7085 http://hdl.handle.net/11449/116632 10.1016/j.jpba.2014.07.008 WOS:000343021100009 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Journal Of Pharmaceutical And Biomedical Analysis |
Direitos |
closedAccess |
Palavras-Chave | #Sulfamerazine #Cyclodextrin #Ternary complex #Solubility #In vitro-release |
Tipo |
info:eu-repo/semantics/article |