Free radical production by azomethine H: Effects on pancreatic and hepatic tissues
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
25/06/1997
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Resumo |
The antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action. |
Formato |
319-324 |
Identificador |
http://dx.doi.org/10.3109/10715769709097811 Free Radical Research, v. 26, n. 4, p. 319-324, 1997. 1071-5762 http://hdl.handle.net/11449/65129 10.3109/10715769709097811 WOS:A1997WY52200004 2-s2.0-0030926689 |
Idioma(s) |
eng |
Relação |
Free Radical Research |
Direitos |
closedAccess |
Palavras-Chave | #Azomethine H #Cu-Zn superoxide dismutase #Glutathione peroxidase #Superoxide radical #Toxicity #alanine aminotransferase #amylase #antimalarial agent #azomethine h #catalase #copper zinc superoxide dismutase #free radical #glutathione peroxidase #reactive oxygen metabolite #superoxide #thiobarbituric acid reactive substance #unclassified drug #alanine aminotransferase blood level #amylase blood level #animal experiment #animal tissue #controlled study #dose response #enzyme activity #intraperitoneal drug administration #male #nonhuman #rat #tissue injury #Alanine Transaminase #Amylases #Animals #Antimalarials #Catalase #Dose-Response Relationship, Drug #Free Radicals #Glutathione Peroxidase #Liver #Male #Naphthalenesulfonates #Pancreas #Rats #Rats, Wistar #Reactive Oxygen Species #Superoxide Dismutase #Superoxides #Thiobarbituric Acid Reactive Substances #Thiosemicarbazones #Animalia |
Tipo |
info:eu-repo/semantics/article |