Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures


Autoria(s): Delgado,Daniel R.; Ruidiaz,Miller A.; Gómez,Sandra M.; Gantiva,Mauricio; Martínez,Fleming
Data(s)

01/01/2010

Resumo

By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures from (278.15 to 308.15) K. The drug solubility was greatest in neat water and lowest in neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropy compensation analysis, it follows that the dissolution process of this drug in ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000900019

Idioma(s)

en

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.33 n.9 2010

Palavras-Chave #cosolvency #sodium naproxen #solubility
Tipo

journal article