Is p190 bcr-abl rearrangement necessary for acute transformation in some p210 CML of childhood?
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2009
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| Resumo |
Chronic myeloid leukemia (CML) is a rare disease in childhood which is almost exclusively associated with bcr-abl p210 (M-bcr) rearrangements. It has been suggested that co-expression of p 190 and p210 may be a pathway of CML progression in adult patients. We report two cases of pediatric patients with a diagnosis of CML who presented co-expression of the p210 and p190 transcripts during progression to the blastic phase. The present data suggest that p190 may be a secondary event in at least some cases of childhood CML, suggesting an association with progression to a blastic crisis in these patients. (c) 2008 Elsevier Ltd. All rights reserved. FAEPA FAPESP CNPq |
| Identificador |
LEUKEMIA RESEARCH, v.33, n.3, p.495-499, 2009 0145-2126 http://producao.usp.br/handle/BDPI/24941 10.1016/j.leukres.2008.04.007 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
| Relação |
Leukemia Research |
| Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #Chronic myelogenous leukemia #Childhood #Blastic crisis #p190 #p210 #CNS involvement #CHRONIC MYELOGENOUS LEUKEMIA #CHRONIC MYELOID-LEUKEMIA #ACUTE LYMPHOBLASTIC-LEUKEMIA #MINIMAL-RESIDUAL-DISEASE #BLAST CRISIS #IMATINIB MESYLATE #MESSENGER-RNA #RT-PCR #CHROMOSOME #TRANSCRIPTS #Oncology #Hematology |
| Tipo |
article original article publishedVersion |
