The ACB technique: a biomagentic tool for monitoring gastrointestinal contraction directly from smooth muscle in dogs


Autoria(s): AMERICO, Madileine F.; OLIVEIRA, Ricardo B.; CORA, Luciana A.; MARQUES, Rozemeire G.; ROMEIRO, Fernando G.; ANDREIS, Uilian; MIRANDA, Jose Ricardo A.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

The aim of this paper was to verify whether AC biosusceptometry (ACB) is suitable for monitoring gastrointestinal (GI) contraction directly from smooth muscle in dogs, comparing with electrical recordings simultaneously. All experiments were performed in dogs with magnetic markers implanted under the serosa of the right colon and distal stomach, and their movements were recorded by ACB. Monopolar electrodes were implanted close to the magnetic markers and their electric potentials were recorded by electromyography (EMG). The effects of neostigmine, hyoscine butylbromide and meal on gastric and colonic parameters were studied. The ACB signal from the distal stomach was very similar to EMG; in the colonic recordings, however, within the same low-frequency band, ACB and EMG signals were characterized by simultaneity or a widely changeable frequency profile with time. ACB recordings were capable of demonstrating the changes in gastric and colonic motility determined by pharmacological interventions as well as by feeding. Our results reinforce the importance of evaluating the mechanical and electrical components of motility and show a temporal association between them. ACB and EMG arecomplementary for studying motility, with special emphasis on the colon. ACB offers an accurate method for monitoring in vivo GI motility.

Brazilian agencies CNPq

FAPESP

CAPES

Identificador

PHYSIOLOGICAL MEASUREMENT, v.31, n.2, p.159-169, 2010

0967-3334

http://producao.usp.br/handle/BDPI/24871

10.1088/0967-3334/31/2/003

http://dx.doi.org/10.1088/0967-3334/31/2/003

Idioma(s)

eng

Publicador

IOP PUBLISHING LTD

Relação

Physiological Measurement

Direitos

restrictedAccess

Copyright IOP PUBLISHING LTD

Palavras-Chave #Neostigmine #scopolamine derivatives #investigative techniques #CANINE COLON #MYOELECTRICAL ACTIVITY #BIOMAGNETIC METHOD #PROXIMAL COLON #MOTOR-ACTIVITY #TRANSIT-TIME #MOTILITY #BIOSUSCEPTOMETRY #HUMANS #PATTERNS #Biophysics #Engineering, Biomedical #Physiology
Tipo

article

original article

publishedVersion