Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
| Data(s) |
01/10/1988
|
|---|---|
| Formato |
7159 - 7163 |
| Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/2845398 Proc Natl Acad Sci U S A, 1988, 85 (19), pp. 7159 - 7163 0027-8424 |
| Relação |
Proc Natl Acad Sci U S A 10.1073/pnas.85.19.7159 |
| Tipo |
Journal Article |
| Cobertura |
United States |
| Resumo |
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism. |
| Idioma(s) |
ENG |
| Palavras-Chave | #Animals #Base Sequence #Cloning, Molecular #Cricetinae #DNA #GTP-Binding Proteins #Gene Expression Regulation #Molecular Sequence Data #Phosphatidylinositols #Receptors, Adrenergic, alpha |
