Trafficking of G protein-coupled receptors.


Autoria(s): Drake, MT; Shenoy, SK; Lefkowitz, RJ
Data(s)

15/09/2006

Formato

570 - 582

Identificador

http://www.ncbi.nlm.nih.gov/pubmed/16973913

99/6/570

Circ Res, 2006, 99 (6), pp. 570 - 582

http://hdl.handle.net/10161/5934

1524-4571

Relação

Circ Res

10.1161/01.RES.0000242563.47507.ce

Airculation Research

Palavras-Chave #Cardiovascular System #Endocytosis #Humans #Protein Transport #Receptors, G-Protein-Coupled #Signal Transduction
Tipo

Journal Article

Cobertura

United States

Resumo

G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.

Idioma(s)

ENG