Energy landscape theory, funnels, specificity, and optimal criterion of biomolecular binding
Data(s) |
2003
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Resumo |
We study the nature of biomolecular binding. We found that in general there exists several thermodynamic phases: a native binding phase, a non-native phase, and a glass or local trapping phase. The quantitative optimal criterion for the binding specificity is found to be the maximization of the ratio of the binding transition temperature versus the trapping transition temperature, or equivalently the ratio of the energy gap of binding between the native state and the average non-native states versus the dispersion or variance of the non-native states. This leads to a funneled binding energy landscape. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Wang J;Verkhivker GM.Energy landscape theory, funnels, specificity, and optimal criterion of biomolecular binding,PHYSICAL REVIEW LETTERS,2003,90(18 ):文献编号:188101 |
Palavras-Chave | #MOLECULAR RECOGNITION #STATISTICAL-MECHANICS #FOLDING FUNNELS #MODEL #DISCOVERY |
Tipo |
期刊论文 |