Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane
Data(s) |
2006
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Resumo |
The interaction of chlorpromazine (CPZ) with supported bilaver lipid (dipalmitoyphosphatidylcholine) membrane (s-BLM) on the glassy carbon electrode (GCE) was investigated using cyclic voltammetry and ac impedance spectroscopy. The experimental data, based on the voltammetric response of Ru(NH3)(6)(3+) associated with the oxidation of CPZ on the electrode, indicated that the interaction of CPZ with s-BLM was concentration and time dependant. The interaction between them could be divided into three stages by the concentration of CPZ: low, middle and high concentration. At the first stage, s-BLM was not affected by CPZ and the interaction was only a penetration of a small quantity of CPZ molecule into s-BLM. At the second stage, the defects formed in s-BLM due to the penetration of more CPZ molecule into s-BLM. At the last stage, a high CPZ:lipid ratio reached in s-BLM, resulting in the solubilization of s-BLM. The interaction time had different effect at three stages. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Liu H;Bai HX;Huang WM;Du LW;Yang XR;Wang EK.Concentration and time dependant behavior of chlorpromazine interaction with supported bilayer lipid membrane,ELECTROCHIMICA ACTA,2006,51(12):2512-2517 |
Palavras-Chave | #GLASSY-CARBON ELECTRODE #PHOSPHOLIPID-MEMBRANES #VESICLES #PARTITION #DRUGS #CHOLESTEROL #METABOLISM #IMIPRAMINE #RECEPTORS #COMPOSITE |
Tipo |
期刊论文 |