Thia-michael addition reactions in water using 3-[Bis(alkylthio) methylene]pentane-2,4-diones as odorless and efficient thiol equivalents
Data(s) |
2007
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Resumo |
3-[Bis(ethylthio)methylene]pentane-2,4-dione (1a) and 3-[bis(benzylthio)methylene]pentane-2,4-dione (1b) have been investigated as non-thiolic and odorless thiol equivalents in thia-Michael addition reactions. In the presence of aqueous p-dodecyl benzenesulfonic acid (DBSA), compound (1) was cleaved and the generated thiols underwent facile conjugate addition to alpha,beta-unsaturated ketones 2 in-situ, affording the corresponding beta-keto sulfides (3) in good yields. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Chai YY;Dong DW;Yan OY;Liang YJ;Wang Y;Li MH;Liu Q.Thia-michael addition reactions in water using 3-[Bis(alkylthio) methylene]pentane-2,4-diones as odorless and efficient thiol equivalents,LETTERS IN ORGANIC CHEMISTRY,2007 ,4(4):281-284 |
Palavras-Chave | #ALPHA #ASYMMETRIC CONJUGATE ADDITION #CHEMOSELECTIVE THIOACETALIZATION #1 #PROMOTED CLEAVAGE #ORGANIC SYNTHESES #ACID #CATALYST #KETONES #MERCAPTANS #BETA-UNSATURATED CARBONYL-COMPOUNDS #3-PROPANEDITHIOL EQUIVALENT |
Tipo |
期刊论文 |