Heritability of white matter fiber tract shapes: A HARDI study of 198 twins
| Contribuinte(s) |
Liu, Tianming Shen, Dinggang Ibanez, Luis Tao, Xiaodong |
|---|---|
| Data(s) |
2011
|
| Resumo |
Genetic analysis of diffusion tensor images (DTI) shows great promise in revealing specific genetic variants that affect brain integrity and connectivity. Most genetic studies of DTI analyze voxel-based diffusivity indices in the image space (such as 3D maps of fractional anisotropy) and overlook tract geometry. Here we propose an automated workflow to cluster fibers using a white matter probabilistic atlas and perform genetic analysis on the shape characteristics of fiber tracts. We apply our approach to large study of 4-Tesla high angular resolution diffusion imaging (HARDI) data from 198 healthy, young adult twins (age: 20-30). Illustrative results show heritability for the shapes of several major tracts, as color-coded maps. |
| Identificador | |
| Publicador |
Springer Berlin Heidelberg |
| Relação |
DOI:10.1007/978-3-642-24446-9_5 Jin, Y., Shi, Y., Joshi, S. H., Jahanshad, N., Zhan, L., de Zubicaray, G. I., McMahon, K. L., Martin, N. G., Wright, M. J., Toga, A. W., & Thompson, P. M. (2011) Heritability of white matter fiber tract shapes: A HARDI study of 198 twins. In Liu, Tianming, Shen, Dinggang, Ibanez, Luis, & Tao, Xiaodong (Eds.) Multimodal Brain Image Analysis: First International Workshop, MBIA 2011, Held in Conjunction with MICCAI 2011, Toronto, Canada, September 18, 2011. Proceedings, Springer Berlin Heidelberg, Toronto, Canada, pp. 35-43. |
| Direitos |
Copyright 2011 Springer-Verlag |
| Fonte |
Faculty of Health; Institute of Health and Biomedical Innovation |
| Palavras-Chave | #Clustering #Curve Matching #Fiber Alignment #HARDI #Heritability #Image Registration #Tractography #White Matter Probabilistic Atlas |
| Tipo |
Conference Paper |
