Imunoexpressão de receptores de calcitonina e corticosteroides em lesões centrais de células gigantes dos ossos maxilares

The aim of this study was to analyze the immunoexpression of calcitonin (CTR) and glucorticoid (GCR) receptors in aggressive and non-aggressive central giant cell lesions (CGCL). This is an immunohistochemistry study (immunoperoxidase technique) of 52 cases of CGCL of the jaws, in which 12 patients were treated with intralesional triamcinolone injections and one with calcitonin nasal spray. The mean of immunostaining was compared between the cell types and clinical subtype of the lesion. The correlations among means were analyzed by Mann-Whitney test. Of the 52 cases studied, 53.8% were females, with a mean of 25.69 years. Most lesions were located in the mandible. Thirty patients (57.7%) had aggressive lesions and 22 (42.3%) of the cases consisted of non-aggressive lesions. Surgery was the treatment of choice in 75% of the cases. In 56.7% of the aggressive CGCL surgery was performed, while 43.4% of patients were submitted to conservative treatment. Among cases submitted to conservative treatment, the majority (n = 8; 61.5%) responded well to treatment. CTR expression was observed in 67.3% and GCR in 96.15% of cases. There was no significant statistical difference between the expression of CTRs and GCRs in mononuclear and multinucleated CGCLscells, regarding aggressiveness, treatment performed for aggressive lesions and the response to conservative treatment (p>0.05). The results of our research suggest that the immunoreactivity of CTRs and GCRs did not influence the response to clinical treatment with calcitonin or triamcinolone in the sample studied and it exhibited a varied expression regardless of the aggressiveness of the lesion.

Imunoexpressão de receptores de calcitonina e corticosteroides em lesões centrais de células gigantes dos ossos maxilares

The aim of this study was to analyze the immunoexpression of calcitonin (CTR) and glucorticoid (GCR) receptors in aggressive and non-aggressive central giant cell lesions (CGCL). This is an immunohistochemistry study (immunoperoxidase technique) of 52 cases of CGCL of the jaws, in which 12 patients were treated with intralesional triamcinolone injections and one with calcitonin nasal spray. The mean of immunostaining was compared between the cell types and clinical subtype of the lesion. The correlations among means were analyzed by Mann-Whitney test. Of the 52 cases studied, 53.8% were females, with a mean of 25.69 years. Most lesions were located in the mandible. Thirty patients (57.7%) had aggressive lesions and 22 (42.3%) of the cases consisted of non-aggressive lesions. Surgery was the treatment of choice in 75% of the cases. In 56.7% of the aggressive CGCL surgery was performed, while 43.4% of patients were submitted to conservative treatment. Among cases submitted to conservative treatment, the majority (n = 8; 61.5%) responded well to treatment. CTR expression was observed in 67.3% and GCR in 96.15% of cases. There was no significant statistical difference between the expression of CTRs and GCRs in mononuclear and multinucleated CGCLscells, regarding aggressiveness, treatment performed for aggressive lesions and the response to conservative treatment (p>0.05). The results of our research suggest that the immunoreactivity of CTRs and GCRs did not influence the response to clinical treatment with calcitonin or triamcinolone in the sample studied and it exhibited a varied expression regardless of the aggressiveness of the lesion.

Receptores de citocinas proinflamatórias na pré-eclâmpsia

Preeclampsia is a disease specific of human pregnancy that affects 3-8% of pregnant women, and it is one of the three leading causes of maternal mortality and morbidity. The disease is characterized by hypertension and proteinuria after the 20th week of gestation. The risk factors for this disease are not completely understood but appear to include dysregulation of the immune response arising from defects in placentation, environmental and genetic factors. This study aimed to determine whether the variation in the amount of proinflammatory cytokine receptors IL-1R2, IL-6R and TNF-αR1 would be involved in preeclampsia. They were recruited women with preeclampsia (n=24) and women who evolved during pregnancy without changes in blood pressure (n=12) were recruited. Clinical and laboratory data were collected. The cytokine receptors (IL-1R2, TNF-αR1 and IL-6R) were assessed in mononuclear cells isolated from peripheral blood using flow cytometry (Control = 8; PE = 24). C-reactive protein (CRP) was determined by CRP ultrasensitive method (Control = 7; PE = 18) was performed using sera pregnant women. Women with preeclampsia had higher weight at the beginning of the pregnancy (p=0.0171) and lower gestational age at delivery (0.0008). Classical monocytes were decreased in preeclampsia but not intermediate or non-classical monocytes. The frequency of IL-1R2 pro inflammatory cytokine receptors is decreased in women with PE only in the subpopulation of non-classical monocytes (p = 0.0011). TNF-αR1 receptor and IL-6R, had a decreased frequency in the three subpopulations of monocyte (classic, intermediate and non-classical) when compared to women with normal pregnancy. An increase in IL-1R2 receptor in TCD4+ lymphocytes, but a decrease in TNF-receptor and IL-6R in women with preeclampsia were found. No differences in the frequency of those receptors in CD3+/CD8+ in preeclampsia. There was no difference in C-reactive protein in preeclampsia. The reduction in the amount of IL-1R2, TNF- αR1 and IL-6R monocytes and lymphocytes can be involved in the regulation of inflammation observed in preeclampsia, contributing to disease.

Análise da expressão dos receptores HER-2 e sua correlação clínica em pacientes com neoplasia gástrica do setor de Oncologia do Hospital de Clínicas da Universidade Federal de Uberlândia-UFU

Introduction: Gastric cancer is currently the fourth higher cancer mortality rate among men in the world and the fifth among women, despite the progressive advances in oncology. The identification of tumor receptors and the development of target-drugs to block them has contributed to increased survival and quality of life of patients, but it becomes important to know the tumor profile of the population being treated, avoiding burdening treatment with examinations and treatments that are not cost-effective. Objective: To evaluate the profile of the population with gastric cancer treated in five years at the Clinical Hospital of the Federal University of Uberlândia and verify the correlation between overexpression of HER-2 receptor with an unfavorable prognosis. Methods: 203 records with gastric cancer were selected through the system database, attending a five-year period, of which 117 paraffin blocks were available for immunohistochemical assessment of HER2 receptor. Results: 2.6% of tumors showed overexpression of HER2, considering for this study two crosses as positive. There was no statistically significant difference in correlation between expression of the HER2 receptor with age, gender, tumor grade, local involvement, Lauren classification, Borrmann classification or staging. Conclusion: For this studied population, we can conclude that there is no need to employ HER2 blockers with high cost as a target-therapy in patients with gastric cancer, since no clinical benefit probably will be obtained due to a low percentage of these patients that demonstrated superexpression of this receptor or even there is no patients with gastric cancer with superexpression of HER2 with more than three crosses of positivity in immunochemistry

Mecanismos celulares activados por receptores P2Y₂ en los procesos ciliares: implicaciones en la hipertensión ocular y el glaucoma

El glaucoma es una neuropatía óptica crónica de etiología multifactorial, que provoca una pérdida progresiva e irreversible de la visión debida a la degeneración de los axones del nervio óptico y la muerte apoptótica de las células ganglionares de la retina (Downs et al., 2011; Quigley, 2011; Soto et al., 2014). Actualmente es la principal causa de ceguera irreversible en el mundo (Pascolini et al., 2012). Aunque su etiología aún no está clara, se sabe que el principal factor de riesgo para desarrollar la enfermedad es el aumento de la PIO debido a anomalías en la dinámica del humor acuoso (Casson et al., 2012). La presencia de receptores purinérgicos P2X y P2Y ha sido descrita en las principales estructuras oculares relacionadas con la producción y drenaje del humor acuoso, los procesos ciliares y la malla trabecular, que son bañadas por dicho fluido (Guzman-­‐Aranguez et al., 2013). Al mismo tiempo, se ha referido la presencia del dinucleótido Ap4A, agonista de dichos receptores, en el humor acuoso, y cómo sus niveles se veían significativamente incrementados en pacientes glaucomatosos (Castany et al., 2011). El objetivo de esta tesis ha sido evaluar la implicación de los receptores purinérgicos P2Y2 de los procesos ciliares en la hipertensión ocular. Más concretamente determinar el papel del Ap4A a través de la activación de dichos receptores sobre la movilización del ion cloruro y del agua a través de las proteínas acuaporinas (AQPs), principales componentes del humor acuoso. Por otra parte, se ha investigado el origen de los niveles incrementados de Ap4A debidos al aumento de la PIO, caracterizando uno de los posibles sensores celulares implicados en dicho proceso. Al mismo tiempo se han evaluado y caracterizado los diferentes mecanismos implicados en dicha liberación...

Prevalência da síndrome metabólica em receptores de transplante renal de acordo com o gênero e tempo pós-transplante /

Metabolic syndrome (MS) is defined as a set of cardiovascular risk factors including obesity, systemic high blood pressure (SHBP), changes in glucose metabolism and dyslipidemia. The prevalence of MS in renal transplant recipients (RTR) ranges from 15% to 65%, increasing the risk of cardiovascular disease (CVD) and reducing renal allograft survival in the long term. The objectives of this study were to determine the prevalence and frequency of MS in renal transplant patients according to gender and time of transplantation and to evaluate renal function in patients with and without MS. Patients and Methods: Crosssectional study conducted from August 2012 to September 2013 involving 153 renal transplant recipients. MS was defined according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). The sample was divided into two groups: patients with metabolic syndrome (WMS patients) and patients without metabolic syndrome (WoMS patients) and according to gender. The WMS patients were stratified into quartiles according to the renal transplantation period (RTP), and variables related to MS were analyzed for both sexes. Results: MS was diagnosed in 58.1% of the studied population, specifically in MS was found 58.4% of men and 41.6% of women (P ˂ 0.05). The male and female with MS were 48.8 ± 11.6 years old vs. 47.1 ± 12.7 years old and the time of post transplantation was 76.1 ± 76.5 months vs. 84.7 ± 65.4 months, respectively (P >0,05). When we compared the sexes in the WMS group, systolic blood pressure (SBP) was higher in men (137.0 ± 18.1 vs. 128.9 ± 13.6 mmHg, P= 0.029), while the other components of MS did not exhibit significant differences. With respect to renal function, when we compared the sexes in the WMS group, the serum creatinine (sCr) was higher in men (1.73 ± 0.69 vs. 1.31 ± 0.47 mg/dL, P= 0.0012), while the urinary protein/creatinine ratio was higher in women (0.48 ± 0.69 vs. 0.37 ± 0.48 mg/dL, P=0.0150). We found no significant difference in the estimated glomerular filtration rate (eGFR) between WMS and WoMS patients for women and men (50.6 ± 19.1 vs. 50.1 ± 18.3 mL/min/1.73 m², P=0.909). We found a significant positive association between eGFR and HDL-c levels (r=0.3371; P=0.0145) for WMS men. The MS components showed no significant differences in RTP for different interquartile ranges, except for diastolic blood pressure (DBP) in women, where there was a significant variation among the quartiles evaluated (P=0.0009). Conclusion: the prevalence of MS was similar in the different quartiles in both sexes, in relation to time post TX. There was no significant difference in eGFR in patients WMS and WoMS, in both sexes. Concluding that the MS did not vary in relation to time post transplant.

Pobreza de Ciudadanía : El ejemplo de un grupo de receptores del PJHD en el barrio Todo Por los Niños, de la ciudad de La Plata

Fil: Bertoncello, Ana Victoria. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Pobreza de Ciudadanía : El ejemplo de un grupo de receptores del PJHD en el barrio Todo Por los Niños, de la ciudad de La Plata

Fil: Bertoncello, Ana Victoria. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Pobreza de Ciudadanía : El ejemplo de un grupo de receptores del PJHD en el barrio Todo Por los Niños, de la ciudad de La Plata

Fil: Bertoncello, Ana Victoria. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

La política migratoria de los estados receptores de la migración centroamericana el caso de México y Estados Unidos

 El presente escrito aborda la situación de la migración humana por razones de trabajo hacia países cercanos o fronterizos, los cuales ofrecen un panorama económico y de oportunidades mejor que el del país de origen. Esto ha dado lugar a una serie de fenómenos sociales que comprenden aspectos no solo laborales sino incluyen también comerciales, legales, políticos y de derechos humanos en medio de los cuales son los trabajadores mismos los más afectados.  The present text addresses to show the situation of human migration due to labour reasons towards near or border countries, theses countries offer an economic and opportunity panorama better than the origin countries. This has allowed a series of social phenomena that include labour, commercial, legal, political and human rights aspects, in the middle of which the workers are the most affected.

Manejo del ganado cunícola

El conejo es un animal herbivoro que se conoce de la antigüedad. Las civilizaciones mas antiguas como la china griega, egipcia e hindu, criaban conejos desde épocas muy remotas. De Grecia el conejo paso a España, en donde ya existia una buena cantidad de estos animales, razón por la que muchos autores han llegado a considerarla como " La tierra del conejo", significado en hebreo· del vocablo hispanja, de donde se deriva como tal el nombre de España. Es aceptado· que de España, el conejo paso al resto de Europa, en tanto en América, el conejo se conocia desde antes de la llegada de los colonizadores españoles, es asi como los indios Azteca de México, tenían . en gran consideración estos pequeños mamiferos, que entre otras cosas representaban la fecundidad y el nexo de lo conocido con lo inexplicable La utilidad que el hombre ha dado al conejo inicialmente ha sido como fuente de alimento, posteriormente utilizó sus pieles para confeccion ar vestimentas. En la actualidad el conejo tiene diversas utilidades en las diferentes ramas de la ciencia podemos encontrarlo como animal experimental a nivel de laboratorios, como vientres receptores temporales de embriones de ganado vacuno (En el caso de la coneja) para su posterior trasplante a las vacas, En la extraccion de suero sanguineo, para fabricar medio de cultivo y fabricar vacunas etc. No cabe duda que este anima, ha sido y sigue siendo de gran utilidad para el hombre por lo que se necesita de sus habitos y su conducta, para llevar a cabo una buena explotación y obtener así el mayor provecho y beneficio posible.

Fantasmas da televisão : o debate sobre a TV digital no Congresso Nacional

Analisa o debate político relativo à implantação da TV digital no Brasil, tendo como referência a audiência pública da Comissão de Ciência, Tecnologia, Comunicação e Informática da Câmara dos Deputados, realizada em 31 de janeiro de 2006, com a participação do ministro das Comunicações, Hélio Costa. Parte-se do pressuposto de que o Congresso Nacional exerceu relevante papel no debate relativo ao tema, mas não exerceu nenhuma influência na escolha do modelo de TV digital, rendendo-se à proposta do Executivo que, por sua vez, acatou o projeto de interesse dos empresários do setor. Constata-se que existem pelo menos três fantasmas que perseguem as empresas brasileiras de televisão: 1) a possibilidade de um novo marco regulatório para o setor de radiodifusão; 2) o aumento da concorrência; e 3) e a ameaça do fim do broadcast, o sistema de difusão de informações utilizado pelo rádio e pela televisão, em que há apenas um emissor e diversos receptores simultaneamente.

Transmissão vertical do hiv e transplante de fígado

"Aborda dois Projetos de Lei na área de saúde pública em tramitação no Congresso Nacional. As proposições referidas são: o Projeto de Lei n° 5522, de 2005, que dispõe sobre a obrigatoriedade da implementação de protocolo terapêutico para a prevenção da transmissão vertical do HIV, e o Projeto de Lei n.º 2.745, de 2003, que dispõe sobre as regras para elaboração da lista nacional de receptores de fígado do Sistema Nacional de Transplante."

Programa Fale Conosco da Câmara dos Deputados : é possível participar e interagir?

Procura conhecer o trabalho de atendimento das mensagens enviadas para o "Fale Conosco", canal de comunicação e interação com a sociedade da Câmara dos Deputados. Busca verificar, mais especificamente, como os provedores de informação, identificados nos órgãos considerados estatisticamente como os maiores receptores de mensagens, concebem o diálogo e a interação com o público externo à Casa. Examina, também, no processo dialógico gerado pela troca de mensagens, a percepção desses provedores quanto ao uso do canal como recurso facilitador de participação política. Para a consecução desse propósito, optou-se pela realização de pesquisa de cunho qualitativo por meio de entrevistas em cada órgão selecionado. São apresentadas questões de cunho teórico metodológico sobre a pesquisa qualitativa e a lógica interpretativa, e de cunho teórico sobre a Internet e os conceitos de governo eletrônico, democracia eletrônica, interação, interatividade e participação. A análise do material empírico parte de uma perspectiva hermenêutica em que se busca correlacionar concepções presentes nas entrevistas dos respondentes do Fale Conosco com algumas das perspectivas teóricas apresentadas. Espera-se com os resultados do estudo, poder contribuir para o enriquecimento dos debates que se fizerem futuramente sobre o serviço de atendimento das mensagens do Fale Conosco, principalmente, no que diz respeito aos seus aspectos valorativos.

[R_Clavijo_SanPrudencio] Intensive Program ERASMUS: TOPCART. Geometric Documentation of the Heritage (report of activities 2010-2011)

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