34 resultados para Junções íntimas


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Ciência da Computação - IBILCE

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Cutaneous melanoma is a malignancy caused by the uncontrolled proliferation of melanocytes. Has been increasing in incidence and mortality over the years. This type of tumor may arise in the skin or any other place where there was migration of neural crest cells. Melanocytes are located in the basal layer of the epidermis forming the epidermal melanin unit, involving a melanocyte to 36 keratinocytes. The proliferation of melanocytes depends on this relationship with the keratinocytes, gap junctions, E-cadherin and desmoglein. The basal membrane is responsible for promoting the integrity of the skin, their adhesion structures shown to be altered in several skin diseases. Some molecules that play the role of adherence in this membrane are the laminins, type IV collagen and type XVII and perlecan. Analysis of protein expression of cell adhesion molecules in melanoma by immunohistochemistry on tissue microarray (TMA). We selected paraffin blocks of patients who were diagnosed with cutaneous melanoma in the period 1995 to 2010, reaching a sample of 124 cases. All these have gone through review of preparation for subsequent histological analysis of tissue microarray (TMA). The protein expression will be analyzed by immunohistochemistry, using markers anti-laminin, anti-collagen type IV and type XVII and anti-perlecan. There was a predominance of female patients, Caucasians and southeastern Brazil. There were frequent in type of extensive superficial ulcers with Breslow depth greater than 4 mm, Clark level IV and mitotic index greater than 6 mitoses per cga. The patients, most of them were female with mean age of 57.13 years and Caucasian. The most frequent histological type was extensive superficial followed by acral lentiginous. Predominated cases very deep, with Breslow thickness greater than 4 mm, Clark IV, ulcerated and on average by 9 cga mitosis, leading to worse prognosis in this sample. It...(Complete abstract click electronic access below)

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This research will try to understand how the concept of gender works at school, since working and discussing the body and sexuality is not a matter to be treated only within the family environment, school is a place for formal and appropriate new knowledge about sexuality, gender and body, in order to be part of the child framework according to adequate theory. At school, which is a place of different social values and especially to build readings world is surrounded by theoretical frameworks appropriate to think of the body not only as biological, but as one that can vary, feel desires and pleasures, changes and growth. This research aims to understand the notes of literature regarding to teaching children about respect for others, how children notice parts of your body, the space they are in, how they build their own and other perceptions, supported by their teachers, how they express themselves and show social rules and behaviors, focusing on building an egalitarian and respectful society regarding to relations between men and women which begin in childhood and is part of sexuality taught at school by teachers. This research will focus on methodology bibliographic through exploratory, interpretive and selective reading

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Airplane Motor Cradles have a complex geometry, since they require different conbinations between different tubes and TIG welded in several angles. In T-25 aircraft and Universal T-27 Tucano (EMBRAER / FAB), besides having to bear the engine balance, these components maintain fixed the nose landing gear in another extremity. They are considered critical to flight safety, and for this reason, the aviation standards are extremely rigid in their production, imposing a zero index” of defects on the final weld metal quality. These structures may be containing an historical of welding repairs, whose effects on their structural integrity are not computed. In this work we analyzed the standardised AISI 4130 steel and the raw steel of tubes to the Airplane Motor Cradles. First of all, microscopy and microanalysis of the base steel, then we analyzed the effects of the TIG weld. Tensile testing was conducted to measure the difference between the mechanical properties of standardised steel and without this treatment

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Titanium and its alloys has been widely used as materials for metallic biomaterials implants are usually employed to restore the hard tissue function, being used for artificial joints and bones, synthetic plates, crowns, dental implants and screws . Objective of this work was the surface modification of Ti-alloy 25Ta from biomimetic surface treatment of employment and deposition of polymer by electrospinning. The league was obtained from the fusion of the pure elements in the arc furnace with controlled atmosphere. The ingots were subjected to heat treatment, cold forged and sectioned discs with 13 mm diameter and 3 mm thick. Two surface treatments was evaluated, biomimetic and electrospinning with PCL fiber. The biomimetic treatment was performed involving alkaline treatment for three molarities 1.5M, 3M and 5M with immersion in SBF. The electrospinning was performed using PCL polymer alloy surface after the alkali treatment Ti25Ta 1M. For this group the polymer coated surfaces were immersed in calcium phosphate containing solution for immobilization of apatite. The results were compared with previous studies using surface treatment group to verify hydroxyapatite formation on the sample surface and it is concluded that the best condition is biomimetic treatment with 5M alkali treatment and heat treatment at 80 ° C for 72 hours

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)