Changes in prolactin secretion in the short- and long-term after adrenalectomy
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
04/11/2013
04/11/2013
2012
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Resumo |
OBJECTIVE: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). MATERIALS AND METHODS: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). RESULTS: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. CONCLUSION: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX. |
Identificador |
Arq Bras Endocrinol Metab,v.56,n.4,p.244-249,2012 0004-2730 http://www.producao.usp.br/handle/BDPI/38041 10.1590/S0004-27302012000400005 http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0004-27302012000400005&lng=en&nrm=iso&tlng=en |
Idioma(s) |
eng |
Publicador |
Sociedade Brasileira de Endocrinologia e Metabologia |
Relação |
Arquivos Brasileiros de Endocrinologia & Metabologia |
Direitos |
openAccess |
Palavras-Chave | #Adrenalectomy #prolactin #corticosterone #adrenocorticotropic hormone #Adrenalectomia #prolactina #corticosterona #hormônio adrenocorticotrófico |
Tipo |
article original article |