Leptospirosis among hospitalized febrile patients in northern Tanzania.
Data(s) |
01/08/2011
|
---|---|
Formato |
275 - 281 |
Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/21813847 85/2/275 Am J Trop Med Hyg, 2011, 85 (2), pp. 275 - 281 http://hdl.handle.net/10161/6334 1476-1645 |
Relação |
Am J Trop Med Hyg 10.4269/ajtmh.2011.11-0176 American Journal of Tropical Medicine and Hygiene |
Tipo |
Journal Article |
Cobertura |
United States |
Resumo |
We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. Among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio [OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic. |
Idioma(s) |
ENG |
Palavras-Chave | #Adolescent #Adult #Aged #Aged, 80 and over #Child #Child, Preschool #Endemic Diseases #Female #Fever #Humans #Infant #Inpatients #Leptospirosis #Male #Middle Aged #Tanzania #Young Adult |