Subclinical psychotic experiences in healthy young adults : associations with stress and genetic predisposition
Data(s) |
01/10/2014
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Resumo |
Stress has been identified as a common trigger for psychosis. Dopamine pathways are suggested to be affected by chronic and severe stress and to play an important role in psychosis. This pilot study investigates the potential relationship of stress and psychosis in subclinical psychotic experiences. It was hypothesized that single-nucleotide polymorphisms (SNPs) previously found to be associated with psychiatric disorders would be associated with both stress and subclinical psychotic experiences. University students (N=182) were genotyped for 17 SNPs across 11 genes. Higher stress reporting was associated with rs4680 COMT, rs13211507 HLA region, and rs13107325 SLC39A8. Reports of higher subclinical psychotic experiences were associated with DRD2 SNPs rs17601612 and rs658986 and an AKT1 SNP rs2494732. Replication studies are recommended to further pursue this line of research for identification of markers of psychosis for early diagnosis and intervention. |
Formato |
application/pdf |
Identificador | |
Publicador |
Mary Ann Liebert |
Relação |
http://eprints.qut.edu.au/78014/2/78014.pdf DOI:10.1089/gtmb.2014.0111 Bruenig, Dagmar, White, Melanie J., Young, Ross McD, & Voisey, Joanne (2014) Subclinical psychotic experiences in healthy young adults : associations with stress and genetic predisposition. Genetic Testing and Molecular Biomarkers, 18(10), pp. 683-689. |
Direitos |
Copyright 2014 Mary Ann Liebert, Inc. This is a copy of an article published in Genetic Testing and Molecular Biomarkers, copyright Mary Ann Liebert, Inc.; Genetic Testing and Molecular Biomarkers is available online at: http://online.liebertpub.com. |
Fonte |
School of Biomedical Sciences; Faculty of Health; Institute of Health and Biomedical Innovation; School of Psychology & Counselling |
Palavras-Chave | #060404 Epigenetics (incl. Genome Methylation and Epigenomics) #060405 Gene Expression (incl. Microarray and other genome-wide approaches) #060410 Neurogenetics #111714 Mental Health #subclinical psychotic experiences #stress #COMT #DRD2 #AKT1 #HLA Region |
Tipo |
Journal Article |